Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Sequence
MAHRAFIQVIFTGAQVFGRAFAESYRQAAAQTAKQTANASRGRGASAEYGGITLDESSKILNIENEQDMNLDKINERFKYLFEINDKEKGGSFYLQSKIYRAAERLKYELAEKEKAANPELNQEQAKSSSTTESPELKK