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PAM16

Gene
PAM16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
149 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.
Similarity
Belongs to the TIM16/PAM16 family.
Mass
16.216 kDa
Sequence
MAHRAFIQVIITGTQVFGKAFAEAYRQAASQSVKQGATNASRRGTGKGEYGGITLDESCKILNIEESKGDLNMDKINNRFNYLFEVNDKEKGGSFYLQSKVYRAAERLKWELAQREKNAKAKAGDASTAKPPPNSTNSSGADNSASSNQ

Gene
PAM16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
147 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
16.5 kDa
Sequence
MAHRLIYQVVVTGTQVFAKAFTQAYKQAATAQAASKTSKSAASKFGGLQLDEACKILDVDETALDKVVAELNKKHKLEDIAESESVLAQIDKKFTHLYTVNSEHKSGSFYLQSKVYRAMERIRGELELDPLPKPEIEEPKKKEEEKK

Gene
PAM16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
146 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
15.993 kDa
Sequence
MAHRALVKIVITGTRVLGHAFAEAYRQAAAQSAAKQGASAMGRNKTGRGNAAAEYGGITLDESCKILNLDAAKDLKLDKVNQRFDYLFNINDKEKGGSFYLQSKIYRASERLKWELAQREKEAAEEKLPKAEDASEDTGEKSPPSS

Gene
PAM16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
139 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
15.622 kDa
Sequence
MAHRAFIQVIFTGAQVFGRAFAESYRQAAAQTAKQTANASRGRGASAEYGGITLDESSKILNIENEQDMNLDKINERFKYLFEINDKEKGGSFYLQSKIYRAAERLKYELAEKEKAANPELNQEQAKSSSTTESPELKK

Gene
PAM16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
138 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
15.147 kDa
Sequence
MAHKFVVTAFLTGSRILGRSFVAAYKQAQAASAYQRAQVKAGNTTGGASLSSGMTLDEACKILNVKPPAGGQANVEEVLSRYKRLFDANDPQKGGSFYLQSKIVRAKERFEREIGPLREKMEAEAEIKEGFKPKVYKD

Gene
PAM16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
136 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
15.233 kDa
Sequence
MAHRVLVQVIFTGARVFGRAFTEAYKQTAAQMAKQGTSSAARSQGGMTNEYGGITLDESCKILNIEENGPEMNLDKVEQRFKYLFDINDKEKGGSFYLQSKIYRAAERLKWELAQREQADKGASAHPQDQQPGPQN

Gene
pam16
Protein
Mitochondrial import inner membrane translocase subunit tim16
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
135 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1/sscA) via its interaction with PAM18/TIM14. May act by positioning PAM18/pamR in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
15.1 kDa
Sequence
MAHRIVTQVVVTGARVFGRAFAEAYKQASAASKYQQKTGKSAGGSSSSGITLDEACKILNVKPPQAGETNLEQVMERFKKLFDLNDPQKGGSFYLQSKILRARERIEAEVREAERKAAHEKELKEGWKPKVYKDR

Gene
pam16
Protein
Mitochondrial import inner membrane translocase subunit tim16
Organism
Danio rerio
Length
129 amino acids
Function
Regulates ATP-dependent protein translocation into the mitochondrial matrix.
Similarity
Belongs to the TIM16/PAM16 family.
Mass
14.284 kDa
Sequence
MAKYLAQIIVMGAQVVGRAFARALRQEFAASQAAAEARGQAGRQSAAASSFTGMTLQEAQQILNISTLTPEEIQKNYEHLFKVNDKAVGGSFYIQSKVVRAKERLDEELSINQQQQTKNKHADEQQQQT

Gene
pam16
Protein
Mitochondrial import inner membrane translocase subunit tim16
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
128 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (ssc1) via its interaction with PAM18/TIM14. May act by positioning pam18/tim14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
14.12 kDa
Sequence
MSLPRAVGRFIIVGSQVMSKAFVQAYKQMIANAAQQSTGQAAASKSSTAVRRGEMTIQEAGSILNIKPESLEEGELEKRFQKMFEINDPKKGGSFYLQSKVFRAHEKLKSELDQKIQEQSPAKPTSSP

Gene
PAM16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
128 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
13.868 kDa
Sequence
MAHRLLVNVIFTGASVFGRAFTEAYKQAAKATASTPQGGAAKSTSVGGIPTDEALKILDLKKTDLSVAKIDEKYAYLFDVNSKDKGNSFYLQSKVYYAMDSLRKELDYLDKLKKTKDGSQGEAGPTST

Gene
PAM16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Homo sapiens
Length
125 amino acids
Function
Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.
Similarity
Belongs to the TIM16/PAM16 family.
Mass
13.825 kDa
Sequence
MAKYLAQIIVMGVQVVGRAFARALRQEFAASRAAADARGRAGHRSAAASNLSGLSLQEAQQILNVSKLSPEEVQKNYEHLFKVNDKSVGGSFYLQSKVVRAKERLDEELKIQAQEDREKGQMPHT

Gene
Pam16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Mus musculus
Length
125 amino acids
Function
Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
13.785 kDa
Sequence
MAKYLAQIIVMGVQVVGRAFARALRQEFAASQAAADARGRAGHQSAAASNLSGLSLQEAQQILNVSKLSPEEVQKNYEHLFKVNDKSVGGSFYLQSKVVRAKERLDEELRIQAQEDREKGQKPKT

Gene
pam16
Protein
Mitochondrial import inner membrane translocase subunit tim16
Organism
Xenopus tropicalis
Length
125 amino acids
Function
Regulates ATP-dependent protein translocation into the mitochondrial matrix.
Similarity
Belongs to the TIM16/PAM16 family.
Mass
13.897 kDa
Sequence
MAKYLAQIMVMGMQVVGRAFTRALRQEFAASRAAAEARGRAGTESAAVSSLSGISLQEAQQILNVSKLTPEEIQKNYEHLFKVNDKEVGGSFYLQSKVVRAKERLDQEMDIQSKTEKPKDETTQT

Gene
PAM16
Protein
Mitochondrial import inner membrane translocase subunit TIM16
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
121 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
13.306 kDa
Sequence
MAHRLLVNVIFTGASVFGRAFTEAYRQAAKASAAGAAGRPAKASSAGGIPVEEAMKILDLEKSELSLDKVEEKYEYLFNVNSKEQGNSFYLQSKVYYAMDTLKKELEYLEKLQNEKGAASN