orc4

Origin recognition complex subunit 4

972 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner. This binding is mediated by the N-terminal A.T hook repeats of orc4.

Belongs to the ORC4 family.

108.613 kDa

MSSSPFTNLGNLDTEAIYENKENEYQTNITNETSNVQNLSSGNDDQQYPNSTNDDANNGLTASQAKLQDIAAVTLFQDNNISTTTLAPPSPSPLRLNEAPRRRGRPRKYPPKPIDEGSEPIIKRKRGRPPKIKSSSPSTKLDDPLKPKRGRGRPRLHPLPVVQPSVDEGTTQNNLQMGLDEPNIIEGFAEGHANLSELKPKRGRGRPRKIKPEEGSSSQNGLSPLVVLPAKRGRGRPPLHRSEQKIANTPISNNVTVESTGTNLHTHSQLNPENEQSSSEFYSLNPQSEIRKEVVVTDQPLFSTADVPVKRKRGRPPLNKPKILFGTSTENKIDENRPKRGRGRPRLERPSGLPLDSKSQSLFKRKRGRPPKIASGIVPLSAFTRKHEDMLHDSDALSLKHFAITSPNNQQFLNNQQRESAPLLPRKRGRPPKKRQENAEIRNITPGLTDSSVHSSSATPQSESSSPNSVSPLLPSSDRLPLLRQSQFTPPPKKPNFEVAIISPKKSQHKLYPNPVVESVFNDVPYSEIDSQLHTIKSTIAARLCGKSHIPLVGHMDEQTKLYQWVRQTIVLGEGNSVIIVGPRGSGKSVLVDDILSRAAQEINEKSYVVRLNGTYQTDDKLALREISRQLSIELESIESDEALKSEMNFSDTLTKLLATLSHPVDLGIAEDVMTTSAAVIFVLEEFDLFVQHSRQMLLYNLFDIAQSRKAPILIIGLTTRYDCSESLEKRVKSRFSHMVIPMRPPSSLSEFEQILKSVLYVSDEGGKDQIITCWNQRVDELLSDTRSHLHKLVQHHYFASRNLKLLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICAVRFEARDIPACNFNSAYQEYRQLHQSSVINAAASGALAHSSRLWGRDVALEAWETLGSIGLIIPVHPSTNVSGALSRQCQLWQPEVDINVVSVGLREHRRLPSHYYRWLKEVI

ORC4

Origin recognition complex subunit 4

529 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.

Belongs to the ORC4 family.

60.705 kDa

MTISEARLSPQVNLLPIKRHSNEEVEETAAILKKRTIDNEKCKDSDPGFGSLQRRLLQQLYGTLPTDEKIIFTYLQDCQQEIDRIIKQSIIQKESHSVILVGPRQSYKTYLLDYELSLLQQSYKEQFITIRLNGFIHSEQTAINGIATQLEQQLQKIHGSEEKIDDTSLETISSGSLTEVFEKILLLLDSTTKTRNEDSGEVDRESITKITVVFIFDEIDTFAGPVRQTLLYNLFDMVEHSRVPVCIFGCTTKLNILEYLEKRVKSRFSQRVIYMPQIQNLDDMVDAVRNLLTVRSEISPWVSQWNETLEKELSDPRSNLNRHIRMNFETFRSLPTLKNSIIPLVATSKNFGSLCTAIKSCSFLDIYNKNQLSNNLTGRLQSLSDLELAILISAARVALRAKDGSFNFNLAYAEYEKMIKAINSRIPTVAPTTNVGTGQSTFSIDNTIKLWLKKDVKNVWENLVQLDFFTEKSAVGLRDNATAAFYASNYQFQGTMIPFDLRSYQMQIILQELRRIIPKSNMYYSWTQL

ORC4

Origin of replication complex subunit 4

470 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Belongs to the ORC4 family.

53.023 kDa

MAAAAAAASVASQAQAVLRGRLCDQAVVHSALRSSPDTNYSKLKYLVASSVSEACNNSVLLLGPRGCGKAAVRFSFLVYSSAPLSAVFSDAGVVFDEMCQWAIYDFTLWVVSAWTEVVDMVLDDLKKDHPDAISVIRLNGMLHSDDNCATKEIARQLCLEHQLSFSKMASSDDNTEFMIDMLRECGLAHKTIIFVLEEFDLFAQGKQRLLYSLLDAMQSLTSQAVVIGVSCRLDADQLLEKRVRSRFSHRKLLFVPSSVDSLQRLMEHLLALPEDSPLPTKYVREYNARITSIFNDKKFKGILSSLTDADATTSHILRFLFRVVSYMDIDSGLLSMQSFMNALSSMQRQPKMDSLQDLSILELYILVCMNRLEDKEKSSYNFITIMKEYKSVQDAYKTSDKYSHTVCFRAFEHLLDRELISFADNKGRNQALEYRPVKLLISSRELAESLKLNTTCPAVLQKLLDRERYM

ORC4

Origin recognition complex subunit 4

436 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).

Belongs to the ORC4 family.

50.327 kDa

MSSRKSKSSNLIQADYISQVQRILRERFCHQSPHGNLFGVQVQYKHLIELLKRTAIHGESNSILIIGPRGSGKTMLINHALKELMEIEGVSENILQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLLDISQSAQTPVVIIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFSFPQYLKIFKEQLSLPSVFPEEIFAEKWNENVQSLSEDRSVKEVLQKHFNVSKNLRSLHMLLMLALNRVTPSHPFITAADLMEANQLCSMDSKGNIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIRPMERTSVNAQREYQLMKLLLDNTQIMNALQKYPNCPTDVRQWATSSLSWL

ORC4

Origin recognition complex subunit 4

436 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).

Belongs to the ORC4 family.

50.374 kDa

MSNRKTKGNSAVHPECLSQVQRILRERFCHQSPHSNLFGVQVQYKHLIELLKRTAINGESNSVLIVGPRGSGKTMLINHALKELMEIREVSENVLQVHLNGLMQINDKIALTEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGNRANSCPVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFDFPQYMKIFKEQLSLPEEFPNKVFAERWNENTQSLSEDSTVREVLQKLFNVNKSLRSLHMLLMLALNRVTVSHPFMTSADLMEAQHLCSLDSKASIIHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVNSQREYQLVKLLLDNTQIMNALQKYSNCPTDVRQWATSSLSWL

ORC4

Origin recognition complex subunit 4

436 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Belongs to the ORC4 family.

50.377 kDa

MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPNCPTDVRQWATSSLSWL

ORC4

Origin recognition complex subunit 4

436 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).

Belongs to the ORC4 family.

50.339 kDa

MSSRKSKNNSLIHTECLSQVQRILRERFCHQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVVFILDEFDLFAHHKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLIEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPNCPTDVRQWATSSLSWL

Orc4

Origin recognition complex subunit 4

434 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).

Belongs to the ORC4 family.

50.105 kDa

MSNRKSKNNIHAECLSQVQRILRERFCHHTPHSNLFGVQVQYKHLIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNGLLQTNDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALQKGNRTSSCPVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFDFPQYLKIFKEQLSLPAEFPDKIFAEKWNENAHCLSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLMEAQHLCSLDAKASIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVNSQREYQLVKLLLDNTQIMNALQKYSNCPTDVRQWATSSLSWL

Orc4

Origin recognition complex subunit 4

433 amino acids

Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Belongs to the ORC4 family.

49.982 kDa

MSSRKTKSNAHAECLSQVQRILRERFCHHSPHSNLFGVQVQYKHLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELMEIEVSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVVEDKVFGSFAENLSFLLEALQKGDRTSSCPVIFILDEFDIFAHQKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFDFPQYLKIFKEQLSLPAEFPDKAFAERWNENVHCLSEDSTVLEVLQKHFSVNKNLQSLHMLLMLALNRVTVSHPFMTSADLMEAQHMCSLDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIKPVERTSVNSQREYQLVKLLLDNTQIMNALQKYSNCPTDVRQWATSSLSWL

orc4

Origin recognition complex subunit 4

432 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).

Belongs to the ORC4 family.

49.411 kDa

MSKRKSKDLCLPVGECISKVHGILRQRLFQHHGKPFGVDSQHKHLVELLKRTVIHGESNSALIIGPRGSGKSMLLKGALEDIFGMKQMKETALQVNLNGLLQTTDKIALKEITRQLHLENVVGDRVFGSFAENLSFLLEALKTGDRKSSCPVLFVLDEFDLFAHHKNQTLLYNLFDIAQSAQTPVAVIGLTCRLDVMELLEKRVKSRFSHRQIHLLNSFSFSQYLQIFQEKLSLPASFPDSQFAEKWNESIKSLVESKLVEDVLQKQYNASKDVRSLHMLMLLAVCRVNVSHPHITAADFLEVFRLRNQDSKANILHGVSVLELCLIIAMKHLQDIYDGEPFNFQMVHNEFQKFIQRKAHSVYNFEKAVVIKAFEHLHQLELIKPMEGLSVRTQKEYRLMKLLLDNTQIVEALQKYPNCPTDVKQWAMSSLS

ORC4

Origin of replication complex subunit 4

417 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Belongs to the ORC4 family.

47.032 kDa

MGKETPAEKSLNLIRGRLCDPSYVFRPLSASSDSNYSKLKFIVSTSITEGCNNSMLLLGPRGSGKAAVLDLGVGDLLEQFPDSVSVIRLNGLLHSDDNCAFKEIAKQLCMEHHLLFSKMASFDDNSQFIIAMLRACGLAHKTIIFVLDEFDMFAQGKQRLLYSLLDAMQSVTSQAVVVGISSRLDADQLLEKRVRSRFSHRKFLFLPPSREELDGLFVHLLSLPADSGFPSGYVSRFNDKIKNLTSDTRFKDILKTLFNANSTVNSFLKFIFCAVSLMNLESGLLSLENFKAALSSMQRQPKLEAVRDCSVLELYLLVCMRRLEVKEQSSYNFISVMKEYKAIHDSFHTSDYYAQNVCLRAFEHLRERQVICYAENRGQSQTGEYRLQKLLISASELHQGMRSHACCPAILLKLLDH

orc4

ORC1-type DNA replication protein 4

410 amino acids

Involved in regulation of DNA replication.

Belongs to the CDC6/cdc18 family.

45.633 kDa

MTPDSSPSSVDDPLFESGHRIFANKDLLKIGHVPEADRIVGRDEEISKLAKRLNGAVHGYSPENVMIYGKTGTGKSLVSKHVCQRAQNAAQDGVEIGTAYIDCAEDNTETQAISSLAAKLNDESSTGISVPHTGLSTSKYYKLLWKTLDAQFDSVIIILDEIDLMNDDSVLMKLSRAEEAGKIDCSVGVIAISNKIQYVDNVNERVKSSFQHKELFFKPYDANQLREIMFNREDAFQDGVLSEDVIPLSAAFAAQEHGDARKAIDILRHAGEVAYEAGAELVTEEHVRQAQQHAEKDRFRELVNGAPTQAKAALLALTELSVNSNDDAFLTSRVYDQYEHICNHLDMDILSVRRFRDILKEQAFLGVVEIEKINKGSAGGIHLQNRLIEDSQVVRETILEDSRMQDWTRE