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GET2

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
357 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
39.037 kDa
Sequence
MSETTDKQLTEAEKRKLLRERRLAKMAQGKASDRLNTILSQGSSVKSVSPPAVTSVLENKATKSTDTATVTDSSTNATSVSPSAAKATPTSTGVSSAISDFDDPEIQDISDVAVNNSGVLALGNLSGLDSNNPSQPNLDEMFQKIMQQQSQHNCDNDNNGENNPMAEMLKMFNSMGGGDNNGGLGGFDSMFSGSPNSPPPESISPEMMKYQADLAKYHTYQEQLWQFRFLVVRILATIFNFAYHFITIPSFTASNHAYVRDLSEVYPLLGFMTIFTSIEVVIIATYYLLFTKLGLFHASNQKSFILKGISTLSMFVPQLLRYEPLVATFLGYKELLGIFVGDLSLVVVMFGLLSFSN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
357 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
39.037 kDa
Sequence
MSETTDKQLTEAEKRKLLRERRLAKMAQGKASDRLNTILSQGSSVKSVSPPAVTSVLENKATKSTDTATVTDSSTNATSVSPSAAKATPTSTGVSSAISDFDDPEIQDISDVAVNNSGVLALGNLSGLDSNNPSQPNLDEMFQKIMQQQSQHNCDNDNNGENNPMAEMLKMFNSMGGGDNNGGLGGFDSMFSGSPNSPPPESISPEMMKYQADLAKYHTYQEQLWQFRFLVVRILATIFNFAYHFITIPSFTASNHAYVRDLSEVYPLLGFMTIFTSIEVVIIATYYLLFTKLGLFHASNQKSFILKGISTLSMFVPQLLRYEPLVATFLGYKELLGIFVGDLSLVVVMFGLLSFSN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
316 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
35.236 kDa
Sequence
MATELSDAEKRKLLRERRQQKFSNGGASSRLNKITGQQQNSFLSSTSVLDEPKVTPSGNKKSSNVSDEEVEKSTKEIQDLLSSIPGNKDNSETDAAETNPEVALFQQLLKMQQQGGGFQNGSPDASTPDLFSSLLNNDTNTTASATQMLPNFVDEKVLKYYKFKVSKLKSYIILIKWALLAPYVYFIMHPNPTVLQASNLLSQIVERSNFFSIFTGLEIVFISIYYQMLKKLQRDNNVTATQNAGGILKYLTMIPEGILPIRNIQGKIGLALEYFDVASMYVTDICFVLVLFGVMKYYHSSFPISVPIEPPIAGIQ

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
316 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
35.236 kDa
Sequence
MATELSDAEKRKLLRERRQQKFSNGGASSRLNKITGQQQNSFLSSTSVLDEPKVTPSGNKKSSNVSDEEVEKSTKEIQDLLSSIPGNKDNSETDAAETNPEVALFQQLLKMQQQGGGFQNGSPDASTPDLFSSLLNNDTNTTASATQMLPNFVDEKVLKYYKFKVSKLKSYIILIKWALLAPYVYFIMHPNPTVLQASNLLSQIVERSNFFSIFTGLEIVFISIYYQMLKKLQRDNNVTATQNAGGILKYLTMIPEGILPIRNIQGKIGLALEYFDVASMYVTDICFVLVLFGVMKYYHSSFPISVPIEPPIAGIQ

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Komagataella phaffii (strain GS115 / ATCC 20864)
Length
313 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
34.393 kDa
Sequence
MSELTEAEKRQLLREKRKAKLSQGGGLDRLKKITGENNSKLSTDVPTKEPTADATTTATELPTQGLETRINAHDDPVSEIPDPLNEGFDGKEPDLDQLIASMFNKSAGHENPNSEEQGVPELMRRFSSILQGGDSGAAGLGAEAGGINPLDLLNSLGGSNIGKAQEEYGSTPEEIEFNKKSIAYKKHQNEVLKAKILVVRLVLILSLLFVYGRDFSLSLFTQTYAPNGSSFMRVFLTLELIFQTSLFFFISKNKNFTDDSLISKLLNIGGAFIPATYRNLLQTASKYQVLLSMFLFDLSIVVVVFAIRAAFNF

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Komagataella phaffii (strain GS115 / ATCC 20864)
Length
313 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
34.393 kDa
Sequence
MSELTEAEKRQLLREKRKAKLSQGGGLDRLKKITGENNSKLSTDVPTKEPTADATTTATELPTQGLETRINAHDDPVSEIPDPLNEGFDGKEPDLDQLIASMFNKSAGHENPNSEEQGVPELMRRFSSILQGGDSGAAGLGAEAGGINPLDLLNSLGGSNIGKAQEEYGSTPEEIEFNKKSIAYKKHQNEVLKAKILVVRLVLILSLLFVYGRDFSLSLFTQTYAPNGSSFMRVFLTLELIFQTSLFFFISKNKNFTDDSLISKLLNIGGAFIPATYRNLLQTASKYQVLLSMFLFDLSIVVVVFAIRAAFNF

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
312 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
34.485 kDa
Sequence
MSDSPSISAEERKRILRERRAAKMAKGNATSRLNTILTQGNSVKDVSSVKSVLDQEPTGATATTTGNHDLDPDHHDIEGFINTPGINASNDSVALSNSEDIDEMFKKIFGGQVPGNGTDGAGSEDPLAQMMKMFSQPGAGTGTNTPFSEDPFSAQPEEFKYQQQLVQYNTYRHQVWKFRFLAVRYFALLANFIYHFYIIGDSISFASSSHQFIRELIPVEPARSFFTLFSTIEVVIIASYYFLGTKEGFFSTATSNNFVVKLLDMGSMVLPQLQQFKTIAVRLLGYYELLAVLLGDLSLVVVLFGLHSVLGN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida tropicalis (strain ATCC MYA-3404 / T1)
Length
307 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
34.672 kDa
Sequence
MSDSTDSPAVLSAEEKRRLLRERRQAKMAKGQATDRLNNILSQGSSVKTTGVKSVLDEPQPTATSSAIHDEDPDIQDISEIASPPPPTPPIGEGSPENIDDIFQKMLQQQVQGKDGKVDPNDPIVQIMNMFKDGSGADGPQEGDVNANEFSNDPVENKYQQDLQAYDTYQQKLWKSRFLVIRVVVTLFNFFYHYLNVPSFHASNYSYVRDLAQDEFPVRNFFTWFAAFEVIIVLQYYTVFHKLGLFHAANQNSMIMKLMSMGSMVLPQLNTYQPLVARFLGYYELFGIIFGDLSLVIVLFGLLSFTK

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida tropicalis (strain ATCC MYA-3404 / T1)
Length
307 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
34.672 kDa
Sequence
MSDSTDSPAVLSAEEKRRLLRERRQAKMAKGQATDRLNNILSQGSSVKTTGVKSVLDEPQPTATSSAIHDEDPDIQDISEIASPPPPTPPIGEGSPENIDDIFQKMLQQQVQGKDGKVDPNDPIVQIMNMFKDGSGADGPQEGDVNANEFSNDPVENKYQQDLQAYDTYQQKLWKSRFLVIRVVVTLFNFFYHYLNVPSFHASNYSYVRDLAQDEFPVRNFFTWFAAFEVIIVLQYYTVFHKLGLFHAANQNSMIMKLMSMGSMVLPQLNTYQPLVARFLGYYELFGIIFGDLSLVIVLFGLLSFTK

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
Length
306 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
33.9 kDa
Sequence
MSEISDAEKRRILREKRQQKFNKGGASSRLAKITGQTENSFLSTESPLDSRESTYPAQETKAPAGNEDSTKQMDELLAKATSKTTSKASSPPGSAEQQNGNPELDLFAQIAKLQQNANNETVSTDPSGTPDIFAQLMASMQQDEAKGGSPGATAQQPIDPAIVEAHNIAVNKLKSYTILVKWLFFLLPYLYYITHSARDPFQHNAVNYVLDRSNFFTVFTTFEIVALSVYYQLLMSAEKSHNVNTLDNNSKILKLVSMVPPGLVPIPNLRGKVAQALQYWDVVSMYLTDLCFAIVLAGLFQYYHSM

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
Length
306 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
33.9 kDa
Sequence
MSEISDAEKRRILREKRQQKFNKGGASSRLAKITGQTENSFLSTESPLDSRESTYPAQETKAPAGNEDSTKQMDELLAKATSKTTSKASSPPGSAEQQNGNPELDLFAQIAKLQQNANNETVSTDPSGTPDIFAQLMASMQQDEAKGGSPGATAQQPIDPAIVEAHNIAVNKLKSYTILVKWLFFLLPYLYYITHSARDPFQHNAVNYVLDRSNFFTVFTTFEIVALSVYYQLLMSAEKSHNVNTLDNNSKILKLVSMVPPGLVPIPNLRGKVAQALQYWDVVSMYLTDLCFAIVLAGLFQYYHSM

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
303 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
33.837 kDa
Sequence
MSEQPLSQDEKRRLLRERRQAKMARGKASERLNNILSQGSSVKGTTDPVSVFDSKPEPTASSTKPAEVSPAVSSHRDPEDDPDLMDIDNVTPEIKVDEPNIDKMLSDIFGANVGGNATDSSQDDFMANMMNMMKQGEGVDGSTGGTAEPQEPGYQSQLNAYNIYQQRLWKFRFSIIRFAAVLTNFFYHYLTIQDYSFTSSPHFYVRALAPHPAVNSFITWFSTCEVAILASFYLITSKNNIYANASDGNLLLKGISMGAMVLPQLRAYQPLVIRLAHYWEVFSMLLGDIFLVVVLFGLVSIYN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
303 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
33.837 kDa
Sequence
MSEQPLSQDEKRRLLRERRQAKMARGKASERLNNILSQGSSVKGTTDPVSVFDSKPEPTASSTKPAEVSPAVSSHRDPEDDPDLMDIDNVTPEIKVDEPNIDKMLSDIFGANVGGNATDSSQDDFMANMMNMMKQGEGVDGSTGGTAEPQEPGYQSQLNAYNIYQQRLWKFRFSIIRFAAVLTNFFYHYLTIQDYSFTSSPHFYVRALAPHPAVNSFITWFSTCEVAILASFYLITSKNNIYANASDGNLLLKGISMGAMVLPQLRAYQPLVIRLAHYWEVFSMLLGDIFLVVVLFGLVSIYN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)
Length
301 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
34.034 kDa
Sequence
MSEPVVDTAELSAEEKKRLLRERRQAKMSKGKATARLNNILSQGSSVKTSGVKSVLDQEKEATSSHDDDPEIQDITEITTPPPRTPPIGEDAPQDIDKIFQTMLQQQQQRGQGANTADDPFAQIMKMFNQTEGPDSLINEGSASTQDPTEIKYHQELLEYNTYNQKLWKFRFLLVRVLVTLFNFFYHYTSISDFHASNYAYVRDLSSEEYPVRDFFTWFATSEVVLVAAYYSVFHSLGLFHAANQNSIILKVMSMGSMILPQLESYKPLVARFLGYYELLGIVLGGLSLVIVLFGLLSFAN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)
Length
301 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
34.034 kDa
Sequence
MSEPVVDTAELSAEEKKRLLRERRQAKMSKGKATARLNNILSQGSSVKTSGVKSVLDQEKEATSSHDDDPEIQDITEITTPPPRTPPIGEDAPQDIDKIFQTMLQQQQQRGQGANTADDPFAQIMKMFNQTEGPDSLINEGSASTQDPTEIKYHQELLEYNTYNQKLWKFRFLLVRVLVTLFNFFYHYTSISDFHASNYAYVRDLSSEEYPVRDFFTWFATSEVVLVAAYYSVFHSLGLFHAANQNSIILKVMSMGSMILPQLESYKPLVARFLGYYELLGIVLGGLSLVIVLFGLLSFAN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
298 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
33.632 kDa
Sequence
MSEPVVDTAELSAEEKKRLLRERRQAKMSKGKATARLNDILSQGSSVKTSGVKSVLDQEKEATPSHDEDPEIQDITEITTPPPRTPPIGEDAPQDIDKIFQSMLQQQGQGADTAGDPFAQIMKMFNQVEGGDSPPSESATSTQDPAELKYRQELLEYNTYNQKLWKFRFLLVRVSVTLFNFFYHYINLSNFHASNYAYVRDLSSEKYPVRDFFTWFATTEVVLVAAYYSIFHSLGLFHAANQNSFVLKAMSMGSMVLPQLEHYKPLVARFLGYYELLGIVLGDLSLVIVLFGLLSFAN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida albicans (strain WO-1)
Length
298 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
33.632 kDa
Sequence
MSEPVVDTAELSAEEKKRLLRERRQAKMSKGKATARLNDILSQGSSVKTSGVKSVLDQEKEATPSHDEDPEIQDITEITTPPPRTPPIGEDAPQDIDKIFQSMLQQQGQGADTAGDPFAQIMKMFNQVEGGDSPPSESATSTQDPAELKYRQELLEYNTYNQKLWKFRFLLVRVSVTLFNFFYHYINLSNFHASNYAYVRDLSSEKYPVRDFFTWFATTEVVLVAAYYSIFHSLGLFHAANQNSFVLKAMSMGSMVLPQLEHYKPLVARFLGYYELLGIVLGDLSLVIVLFGLLSFAN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
298 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
33.632 kDa
Sequence
MSEPVVDTAELSAEEKKRLLRERRQAKMSKGKATARLNDILSQGSSVKTSGVKSVLDQEKEATPSHDEDPEIQDITEITTPPPRTPPIGEDAPQDIDKIFQSMLQQQGQGADTAGDPFAQIMKMFNQVEGGDSPPSESATSTQDPAELKYRQELLEYNTYNQKLWKFRFLLVRVSVTLFNFFYHYINLSNFHASNYAYVRDLSSEKYPVRDFFTWFATTEVVLVAAYYSIFHSLGLFHAANQNSFVLKAMSMGSMVLPQLEHYKPLVARFLGYYELLGIVLGDLSLVIVLFGLLSFAN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida albicans (strain WO-1)
Length
298 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
33.632 kDa
Sequence
MSEPVVDTAELSAEEKKRLLRERRQAKMSKGKATARLNDILSQGSSVKTSGVKSVLDQEKEATPSHDEDPEIQDITEITTPPPRTPPIGEDAPQDIDKIFQSMLQQQGQGADTAGDPFAQIMKMFNQVEGGDSPPSESATSTQDPAELKYRQELLEYNTYNQKLWKFRFLLVRVSVTLFNFFYHYINLSNFHASNYAYVRDLSSEKYPVRDFFTWFATTEVVLVAAYYSIFHSLGLFHAANQNSFVLKAMSMGSMVLPQLEHYKPLVARFLGYYELLGIVLGDLSLVIVLFGLLSFAN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
294 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
33.597 kDa
Sequence
MSSELSETEKRKLIRERRQKKFSNGGASARLNRITGQAENSQLDTESPLDSKSSRETTPTVTKVDSNTEEMDELLENIATSPSNKVEKSQKKKEQATSPQETIDPELEIFKQLAENQQNDVSTPDLFSMLRSMKDNMAKSAATDTNPPLEPVDQQLLDYNNYLINNLKVWSIIFKWCFFLIPYLFALTRSEPISFLPEQFSNPSNFFMIFLSFEIVATSIYFQKLQNIEKSNKINGFQSNNKIVNLVSLIPEGVLPVPDIKGKVIMALQYWDVFSMFLTDICFVLVMMGLFKLI

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Clavispora lusitaniae (strain ATCC 42720)
Length
292 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
32.394 kDa
Sequence
MSELSAEEKRKLLRERRQAKMAQGKATDRLNNILSQGSSVKSSNVTSVLDKPEKATTTVMDLPSRETQSPTPLHDDPEVPDITSLLKEKENEAPDMEAMLQQILGGSGAHTGPGNDGGANFLQEMMKAMAEDPSGGSTAEESSYQSQLSQYHAYEQKQWKARFLVVRWIIHTLNFVYHYIASGYKLSASPYAFVRAQAVDSHVRTFFTAFLTVEVAVISAYFLVMSQPKFKDFSRENLVSRILSMASAVVPAVGRYQPLVTRALVYWNGASIFVGDLMLMVFYFGITSVLGN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Clavispora lusitaniae (strain ATCC 42720)
Length
292 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
32.394 kDa
Sequence
MSELSAEEKRKLLRERRQAKMAQGKATDRLNNILSQGSSVKSSNVTSVLDKPEKATTTVMDLPSRETQSPTPLHDDPEVPDITSLLKEKENEAPDMEAMLQQILGGSGAHTGPGNDGGANFLQEMMKAMAEDPSGGSTAEESSYQSQLSQYHAYEQKQWKARFLVVRWIIHTLNFVYHYIASGYKLSASPYAFVRAQAVDSHVRTFFTAFLTVEVAVISAYFLVMSQPKFKDFSRENLVSRILSMASAVVPAVGRYQPLVTRALVYWNGASIFVGDLMLMVFYFGITSVLGN

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
289 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
31.959 kDa
Sequence
MSEVSEAEKRRILREKRKQKFSKGAGSARLHKITTQQPGGASGDSTVTSAEISDNEGSLQRGSNSGQSTREIDDLLAAMDPPIEPAEPLESAAPEVAFIQQLMKMQQGSATPPADEKAGGLFSPLLERLAEQEAGGAPVVSGEVGVHQFQVRQLKAYMLLLRWAILLPFIYYVMHPGTAHWLHTSRFLHFVMEPRNFFMVFTTFEVASISIYYQVLLTLERTNKVNSLSYSSKLVTWAGLVPDGMLPIDNLQGKVVVALHYWDILSMYLTDLSLCLVAAGLMKYYHAAP

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
289 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
31.959 kDa
Sequence
MSEVSEAEKRRILREKRKQKFSKGAGSARLHKITTQQPGGASGDSTVTSAEISDNEGSLQRGSNSGQSTREIDDLLAAMDPPIEPAEPLESAAPEVAFIQQLMKMQQGSATPPADEKAGGLFSPLLERLAEQEAGGAPVVSGEVGVHQFQVRQLKAYMLLLRWAILLPFIYYVMHPGTAHWLHTSRFLHFVMEPRNFFMVFTTFEVASISIYYQVLLTLERTNKVNSLSYSSKLVTWAGLVPDGMLPIDNLQGKVVVALHYWDILSMYLTDLSLCLVAAGLMKYYHAAP

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Saccharomyces cerevisiae (strain RM11-1a)
Length
285 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function.
Similarity
Belongs to the GET2 family.
Mass
31.493 kDa
Sequence
MSELTEAEKRRLLRERRQKKFSNGGASSRLNKITGQASSHLNAESPLDAPSAAKTTPPASVHSATPDIKEDSNVAPQLDLLKQLAAMQGQGTGKSTPQDSSTPDLLSLLSSMNTGMPSAEGTPSFGQAAPAAPINQAALDYHDYLLNRLKAWTILVKWVFFLLPYLYLITRPNSSVWPAYAFTQSAWFAPLRNPSNFTRIFATFEFLSISIYYQLLKNVEHKSKIKNLQDTNKLVKLVSLVPEGVIPVANLKGKLITLLQYWDLLSMLITDISFVLIVLGLLTYL

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
285 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function.
Similarity
Belongs to the GET2 family.
Mass
31.463 kDa
Sequence
MSELTEAEKRRLLRERRQKKFSNGGASSRLNKITGQASSHLNAESPLDAPSAAKATPPASVHSATPDIKEDSNVAPQLDLLKQLAAMQGQGTGKSTPQDSSTPDLLSLLSSMNTGMPSAEGTPSFGQAAPAAPINQAALDYHDYLLNRLKAWTILVKWVFFLLPYLYLITRPNSSVWPAYAFTQSAWFAPLRNPSNFTRIFATFEFLSISIYYQLLKNVEHKSKIKNLQDTNKLVKLVSLVPEGVIPVANLKGKLITLLQYWDLLSMLITDISFVLIVLGLLTYL

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
285 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function.
Similarity
Belongs to the GET2 family.
Mass
31.493 kDa
Sequence
MSELTEAEKRRLLRERRQKKFSNGGASSRLNKITGQASSHLNAESPLDAPSAAKTTPPASVHSATPDIKEDSNVAPQLDLLKQLAAMQGQGTGKSTPQDSSTPDLLSLLSSMNTGMPSAEGTPSFGQAAPAAPINQAALDYHDYLLNRLKAWTILVKWVFFLLPYLYLITRPNSSVWPAYAFTQSAWFAPLRNPSNFTRIFATFEFLSISIYYQLLKNVEHKSKIKNLQDTNKLVKLVSLVPEGVIPVANLKGKLITLLQYWDLLSMLITDISFVLIVLGLLTYL

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
280 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
31.32 kDa
Sequence
MSLSEAEKRKILRERRQQKFSRGGASERLNKIVGGQGSQLDTKSALDEKPEVVEEIPREAVKPEMNSSVQAKKESTAQAKAEDPQVELFRQLAEMQGQGATESTPDLFSMMKNLGATGDSPFPMAEQQVEAIDPELVEYHKYRVNTLTAKTTLVKWIVLLAYIFLLTRTDDTYFPFVVRSYLPEVFTSQSSFFSIFLTFEILATSIYYQLSVGVERETGVKTLQDTSKIVSLVSMVPEGILPIADLRGKVILAMKYWNIIAMMIGDVCFVLVAIGLVSQI

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
280 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
30.55 kDa
Sequence
MPSDREKQRILRERRQAKMAKGGASDRLNKILSQGSSVKTSAVSVLDQPQPADHDPEGMDISTIASKPTPEPELDIDAMLNSVLGGNMGAGGAANGDPGSDPFTQMMMNMMQGGGPEGMLGQEGGTNPMSANMEYQQQLIAYNLYQQRKVRHRFLVVRMVSILANFVYHFLTISDFSFSPSANPFIRSIPPTSSVSSFFQIFVAIEAVLVAAYIAASRNVPSNNNGLLVKGISMAAMFVPKLQRFQPLIMKIIGCWDTVTFVLNDLGLVVLLFGLISFRR

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
280 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
31.32 kDa
Sequence
MSLSEAEKRKILRERRQQKFSRGGASERLNKIVGGQGSQLDTKSALDEKPEVVEEIPREAVKPEMNSSVQAKKESTAQAKAEDPQVELFRQLAEMQGQGATESTPDLFSMMKNLGATGDSPFPMAEQQVEAIDPELVEYHKYRVNTLTAKTTLVKWIVLLAYIFLLTRTDDTYFPFVVRSYLPEVFTSQSSFFSIFLTFEILATSIYYQLSVGVERETGVKTLQDTSKIVSLVSMVPEGILPIADLRGKVILAMKYWNIIAMMIGDVCFVLVAIGLVSQI

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
280 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
30.55 kDa
Sequence
MPSDREKQRILRERRQAKMAKGGASDRLNKILSQGSSVKTSAVSVLDQPQPADHDPEGMDISTIASKPTPEPELDIDAMLNSVLGGNMGAGGAANGDPGSDPFTQMMMNMMQGGGPEGMLGQEGGTNPMSANMEYQQQLIAYNLYQQRKVRHRFLVVRMVSILANFVYHFLTISDFSFSPSANPFIRSIPPTSSVSSFFQIFVAIEAVLVAAYIAASRNVPSNNNGLLVKGISMAAMFVPKLQRFQPLIMKIIGCWDTVTFVLNDLGLVVLLFGLISFRR

Gene
GET2
Protein
Golgi to ER traffic protein 2
Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229)
Length
266 amino acids
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Similarity
Belongs to the GET2 family.
Mass
29.743 kDa
Sequence
MSELSDAEKRRILKERRQKKFGSGGGTNRLNKITGQADSLMSTESTLDQRERTPEAAINTRQNEAGNNQSTTDNNPQVSLLKQLAEQDRQEGSEAPPDLMSMLQSMTGGDAKNGTPPTLGTPPAPVDQSMLDYHNYLVNRLKAWSIIIKWIVLLPYMYVVTHDVPLSLPFGLMDSSNFFSVLMGFEIVATSIYYKRLQSIEKGTSVNTMMHGSMIAKLISLIPDQAPQQKNLKSRLFTLLQYWDVVSMLITDICFVLVVLGIFTHI