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CAP1

Gene
cap1
Protein
Adenylyl cyclase-associated protein
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
551 amino acids
Function
The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.
Similarity
Belongs to the CAP family.
Mass
60.243 kDa
Sequence
MSDMINIRETGYNFTTILKRLEAATSRLEDLVESGHKPLPNMHRPSRDSNSQTHNISFNIGTPTAPTVSTGSPAVASLHDQVAAAISPRNRSLTSTSAVEAVPASISAYDEFCSKYLSKYMELSKKIGGLIAEQSEHVEKAFNLLRQVLSVALKAQKPDMDSPELLEFLKPIQSELLTITNIRDEHRTAPEFNQLSTVMSGISILGWVTVEPTPLSFMSEMKDSSQFYANRVMKEFKGKDDLQIEWVRSYLTLLTELITYVKTHFKTGLTWSTKQDAVPLKTALANLSASKTQAPSSGDSANGGLPPPPPPPPPSNDFWKDSNEPAPADNKGDMGAVFAEINKGEGITSGLRKVDKSEMTHKNPNLRKTGPTPGPKPKIKSSAPSKPAETAPVKPPRIELENTKWFVENQVDNHSIVLDSVELNHSVQIFGCSNCTIIIKGKLNTVSMSNCKRTSVVVDTLVAAFDIAKCSNFGCQVMNHVPMIVIDQCDGGSIYLSKSSLSSEVVTSKSTSLNINVPNEEGDYAERAVPEQIKHKVNEKGELVSEIVRHE

Gene
CAP1
Protein
AP-1-like transcription factor CAP1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
499 amino acids
Function
Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Involved in the oxidative stress response in via multiple pathways, including the cellular antioxidant defense system, carbohydrate metabolism and energy metabolism, protein degradation, ATP-dependent RNA helicase, and resistance pathways. The ability of the major systemic fungal pathogen of humans to sense and respond to reactive oxygen species, such as H(2)O(2) generated by the host immune system, is required for survival in the host and therefore virulence. Regulates the transcription of COR33, GLR1, GTO1, GTT1, GTT1, TRR1, TRX1, SOD1, CAT1, and the transcription regulator TSA1. Participates in the apoptosis by regulating the expression of the glutathione reductase gene and glutathione content. Plays also a role in the peroxide-mediated induction of MDR1 and other drug response genes such as PDR16, MDR1, FLU1, YCF1, and FCR1. Regulates trehalose accumulation which is important for the oxidative stress tolerance. Recruits ADA2 to its target promoters. Activity of CAP1 is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress induces nuclear accumulation and as a result CAP1 transcriptional activity. Nuclear export is restored when disulfide bonds are reduced by thioredoxin, whose expression is controlled by CAP1, providing a mechanism for negative autoregulation.
Similarity
Belongs to the bZIP family. YAP subfamily.
Mass
54.998 kDa
Sequence
MTDIKRNFSDIASPANLDDTKKLHVDSTATTKVGRKPIDTEPKSKRTAQNRAAQRAYRERKERKMKELEDKVRLLEDANVRALTETDFLRAQVDVLKNELAKYTGGSDFSDLNLPTKVGHLSHPNNHHSNVSTGTPHGSMSSSNSVASLDNDKPSSASSVSNNSPGFAFDNPWSKDNIQKLKHQHQQQQQKVPQGVPDLVSGSSSSSTPLNDNLLVTPESLTGLSTSSKYTGQNNVPTNLDFTNQFDEQVDPFCVKLNEACGTKSNPVPKFKRSGSKANTSVTNNSPLAHLVSPESQQYTNSSNIDFMNDPFFNGVGTDYNFNFDSKNGSIQDPLSFLQDDNFDLALAFGDPSPTGNEAEADPISLLTTEESIYDPLTNNSDKLCSTVKADDVNTDFNFNDFVKNSLPEKQEKGKYEPPSTSKTTNNNEEEDKDEVVPAPPQTLKCSEIWDRITSHPKYTELDIDGLCNELKSKAKCSEKGVVINTADVNQLLERSIKH

Gene
CAP1
Protein
Cyclase-associated protein 1
Organism
Arabidopsis thaliana
Length
476 amino acids
Function
Actin monomer binding protein that accelerates the exchange of ADP for ATP. Regulates the pool of unpolymerized ATP-actin. Key intermediate between actin-depolymerizing factor (ADF)-mediated disassembly and the profilin-based nucleation and elongation machinery.
Similarity
Belongs to the CAP family.
Mass
50.97 kDa
Sequence
MEEDLIKRLEAAVTRLEGISSNGGGVVSLSRGGDFSSAAGIDIASSDPSILAYEDLISQCVGRALTAAEKIGGPVLDVTKIVAEAFASQKELLVRIKQTQKPDLAGLAGFLKPLNDVTMKANAMTEGKRSDFFNHLKAACDSLSALAWIAFTGKDCGMSMPIAHVEESWQMAEFYNNKVLVEYRNKDADHVEWAKALKELYLPGLREYVKSHYPLGPVWNASGKPASAPAKGPPGAPAPPPAPLFSAESSKPSSSSNQKQGMSAVFQQLSSGAVTSGLRKVTDDMKTKNRADRSGAVSAVEKETRTSKPAFSKTGPPKMELQMGRKWAVENQIGKKDLVISECDSKQSVYIYGCKDSVLQIQGKVNNITIDKCTKVGVVFTDVVAAFEIVNCNNVEVQCQGSAPTVSVDNTTGCQLYLNKDSLETAITTAKSSEINVMVPGATPDGDWVEHALPQQYNHVFTEGKFETTPVSHSGA

Gene
CAP1
Protein
Adenylyl cyclase-associated protein 1
Organism
Pongo abelii
Length
475 amino acids
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Similarity
Belongs to the CAP family.
Mass
51.561 kDa
Sequence
MADMQNLVERLERAVGRLEAVSHTSDMHRGYGDSPSKAGAAPYVQVFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPADNKLSDLLAPISEQIKEVITFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSGLPSGPSAGSGPPPPPPGPPPPPVSTSSGSDESASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPLRSGPKPFSAPKPQTSQSPKPATKKEPAVLELEGKKWRVENQENVSNLVIEDTELKQVAYIYKCVSTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSGDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG

Gene
CAP1
Protein
Adenylyl cyclase-associated protein 1
Organism
Homo sapiens
Length
475 amino acids
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Similarity
Belongs to the CAP family.
Mass
51.901 kDa
Sequence
MADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAENKLSDLLAPISEQIKEVITFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSGLPSGPSAGSCPPPPPPCPPPPPVSTISCSYESASRSSLFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKRATKKEPAVLELEGKKWRVENQENVSNLVIEDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG

Gene
CAP1
Protein
Adenylyl cyclase-associated protein 1
Organism
Macaca fascicularis
Length
475 amino acids
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Similarity
Belongs to the CAP family.
Mass
51.628 kDa
Sequence
MADMQNLVERLERAVGRLEAVSHTSDMHRGYGDSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPADNKLSDLLAPISEQIKEVITFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLVWSKTGPVAKELSGLPSGPSAGSGPPPPPPGPPPPPVSTSSGSDESASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKPATKKEPAVLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSRDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG

Gene
Cap1
Protein
Adenylyl cyclase-associated protein 1
Organism
Rattus norvegicus
Length
474 amino acids
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Similarity
Belongs to the CAP family.
Mass
51.589 kDa
Sequence
MADMQNLVERLERAVGRLEAVSHTSDMHCGYGDSPSKGAVPYVQAFDSLLANPVAEYLKMSKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSDLLAPISEQIQEVITFREKNRGSKFFNHLSAVSESIQALGWVALAAKPGPFVKEMNDAAMFYTNRVLKEYRDVDKKHVDWVRAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSGLPSGPSVGSGPPPPPPGPPPPPVPTSSGSDDSASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKPATKKEPALLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSRDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG

Gene
Cap1
Protein
Adenylyl cyclase-associated protein 1
Organism
Mus musculus
Length
474 amino acids
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Similarity
Belongs to the CAP family.
Mass
51.565 kDa
Sequence
MADMQNLVERLERAVGRLEAVSHTSDMHCGYGDSPSKGAVPYVQAFDSLLANPVAEYLKMSKEIGGDVQKHAEMVHTGLKLERALLATASQCQQPAGNKLSDLLAPISEQIQEVITFREKNRGSKFFNHLSAVSESIQALGWVALAAKPGPFVKEMNDAAMFYTNRVLKEYRDVDKKHVDWVRAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSGLPSGPSVGSGPPPPPPGPPPPPISTSSGSDDSASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKPATKKEPALLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSRDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG

Gene
CAP1
Protein
Adenylyl cyclase-associated protein 1
Organism
Bos taurus
Length
472 amino acids
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Similarity
Belongs to the CAP family.
Mass
51.273 kDa
Sequence
MADMRNLVERLERVVGRLEAVSHASDTHCGYGDSAAKAGTTPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSDLLAPISEQIQEVVTFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSRTGPVAKELSGLPSGPSAGSGPPPPPPGPPPPPVPTSSGSDDSASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGLIRSGPKPFSASKPDPPKPVAKKEPALLELEGKKWRVENQENVSNLMIEDTELKQVAYIFKCVNSTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDVKVQVMGKVPTISINKTDGCHVYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG

Gene
cap1
Protein
F-actin-capping protein subunit alpha
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
276 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
30.422 kDa
Sequence
MSSTVELASSFIEGAPPGEALTSDGSDIIPSLAPAFERYNEKQLTTVKLPGASQEVIVSEFNKIEGNRYFDVESQTSFGVDHVTQQASGAQSYVLESQNADLIHVEVHSRSNQCSKSLLKSLAKHAAEHYPNCSYGVYPTEDDTAVAILLVANRYSPNNFWNGRFRSIYRVPVSESTTVSGKILVDVHYYEDGNVALNTNKPINIAIPSISAESIISRIAAAERDYQEELNRAFVQMAEGAFKNLRRQLPITRQKVEWEKVGGYRLGQDISGGKGR

Gene
cap1
Protein
F-actin-capping protein subunit alpha
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
273 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
29.976 kDa
Sequence
MASTVDIASSFIEGAPPGELADVVADVKTLTSNGADIIPSLAPAFERYNETQLATVKLPGASQEVLISEYNKLDGNRYFDVESQTSFEVDHVTQEASAAQSYVLDSQNADLIKSLLKSLGAHAREHYPNCAYGVYPIENDSAVAILLVSNRYSPNNFWNGRFRATYQFPVSEPTTVTGKIQVDVHYYEDGNVALNTNKPLNLSVSSLSAESIISRIATAERDYQEDLNRAFVQMAEGAFKGLRRQLPITRQKVEWEKVGGYRLGQDISGGKGR

Gene
cap1
Protein
F-actin-capping protein subunit alpha
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
273 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
30.039 kDa
Sequence
MASTVEFASSFIEGAPPGELADVVSDIKTLTSDGDDIIPSLAPAFERYNESQLATVKLPGASQEVIVSEFNRLEGSRYFDVESQTSFEVDHITQSTSAAQSYVLESQNADLIKSLLKTLGAHAREHYPSSSYGVYPIEKDSAIAILLVANRYSPNNFWNGRYRSIYQFPVGDSTTITGKIHVDVHYYEDGNVALNTTKPLNISVPNASAESIISRIASAERNYQEELNKAFGQMAEGAFKSLRRQLPITRQKVEWEKVGGYRLGQDISGGKGR

Gene
CAP1
Protein
F-actin-capping protein subunit alpha
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
273 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
29.917 kDa
Sequence
MSDIETVSSFVEGAPPGELADVIADIKSLTLETNPDIVNSLTPAFEKYNEEQFVTVKLPGSSQPVIISSYNSLGDGRYFDVESSSSFTFDHTTQKASAVQSHVLEGAQADLVKSTLKSIGPYVDEHFANAAHGVYPIESDSKIAIVIVGNKYSPNNFWNGRWRSLYILDPSSGALEGSLKVDVHYYEDGNVRLLTNKPVSSTISSANGAGIVREISAMEKRYQEELNKGFVSLSEGAFKGLRRQLPVTRQKIEWDRVTSYRLGQDIGNGGSRR

Gene
CAP1
Protein
F-actin-capping protein subunit alpha
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
268 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
30.699 kDa
Sequence
MSSSKFEEVINKIINDSPPGELREVYDDLIKITSENSKNTILDAIENYNVQNCIPIEVNGNSVIISKYNKEGAKFFDPVNSVIFSVNHLERKGLDIEPYEFTHAKIEKGQLKELHDKLHEYLLQSFPGDVSFAVYPVPEEISKISIIIVSTKYNPNNFWNGHWRSSYIYDLETRELSGQISTQVHYYEDGNVSFQSGKDINQSNVDDVVCTIRDIETNFENDLDLSFFDLNEKQFKALRRRLPVTRSKINWGSAIGSYRLGKNAAEGK

Gene
CAP1
Protein
F-actin-capping protein subunit alpha
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
266 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
30.009 kDa
Sequence
MSSSVGLDTIVSSLVKSSPPGELDGISQDLSAILSSKSNSSTVNTAIEKYINENSGVFSSTYIASKINKHESSTKYIDFIGKKLFNIDLHKQTAIDFEDYEPEVKYPAYFDELVKKLTEYGEDHYPSKYAFTIVPDGSDLQIIIIGQKLNYENFYTGLWKSHYKIKSGSIEGEAKLDIHYYEDGNVRLNFEESTSGTLSSSNASEIVNFINNAENEMTLKIVEDFNELNQKYFKNLRRLLPVTRSKINWGQAIGNYRLGSDVVHNK

Gene
CAP1
Protein
F-actin-capping protein subunit alpha
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
262 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
29.667 kDa
Sequence
MSNDFDTIIKNIIKDSPAGELEEVYQDLITIAGENSKETIIDAIAEYNVENSIPIDVDGKDVIISKYNKQGTKFVDPVNGIQFSVDHLHQKGLDVEEYSADIDADQKKAITDLGNYLSTNFPGRATFAVLPLEEQSKTAIIIVSTKYNPSNFWNGHWKSEYVYDKTEGKLSGTIDIDVHYYEDGNVKFHSSKLVEETNIKDPVASIKELEHKFEQDLQESFTDLNEKQFKSLRRRLPITRARVNWGKAIGNYRLGRDAAQGK

Gene
CAP1
Protein
F-actin-capping protein subunit alpha
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
262 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
29.968 kDa
Sequence
MSEFEKIVRDIVFDSPPEEISLVYDNLQVLSDGQSKQQIASIIQEFNEKHRVPAAKGEERYLVSEYNKSGSKYFDPVNKVLFAVDHITREASDIEEYTSEDATQVQSDLYDELSKYVSNFFPDTAVFNVFKIPESDQYAIIVVSNKKSLGDFWTGYWLSEYVYDVDGDTISGEVSVDAHYFEDGNVRFKSTASLESAQTDSPIVSIKQFENEFEKNLINKFQYMNETQFKGLRRRLPVTRAKINWGQGIGNYRLGRDAAQGA

Gene
CAP1
Protein
F-actin-capping protein subunit alpha
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
262 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
28.699 kDa
Sequence
MSRSNQEALADFVADAPPGELNQVVEAISTVVDGNSSILSKLETDVHNKILDQCMVVSLGKSKSLVSKYNQLSKDTFYDSQSGQKFEFDFDTKKATPSGSHGSDSPIQGALDKYFSAHFPSEGAAGVFPQDDGSIALVLVDGKYNPANYWNGKWRSVYIFESGSLSGTIDVDVHYYEDGNVRLKSSEKVDLGSVSESDIVDAISKAEQQFQEKLNKSFNGLNEDSFKALRRQLPVTRSKINWGKSISNYRLGKDINVGGGRE

Gene
CAP1
Protein
F-actin-capping protein subunit alpha
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
261 amino acids
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Similarity
Belongs to the F-actin-capping protein alpha subunit family.
Mass
29.684 kDa
Sequence
MSKFSDIITQLLFDAPPREINSVYDSLVIITEDTDNDTLLDALKRCLVAKRLPIDVEGSPTIVTEYNKDGAKYFDPFKKVLFSVDCLDRVGLDIEPHESETTPYQEKLYEELQKYVAKNFPGDSACTVLPTGDDDELAIIIVSSKFSPSNYWSGYWKSEYIYSPEERSLTGRIDVVVHYFEDGNVKFSTQEFIDKEDINDPISCIRALESEIETGLDESFSKLNQTQFAKLRRKLPVTRSKVNWGKAISNYRLGKDAAQGK

Gene
CAP1
Protein
Adenylyl cyclase-associated protein 1
Organism
Sus scrofa
Length
233 amino acids
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Similarity
Belongs to the CAP family.
Mass
25.079 kDa
Fragment
multiple
Sequence
LEAVSHASDTHYGYGDSAAKEIGGDVLKHAEMVHTGLKEYKDVDKXGPVAKELSGLPSGPSAGSGPPPSALFAQIHQGESITHALKHVADDEKTHKNPADKAQSGPVRXGPKPFSASKPGISPSPKPVTKKWRXENXENVSNLVIDDTELKSVNSTLQIKXXINSISVDNYKVPXISINKXDGRHIYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQXKXIWNGQK