Protein
2-hydroxypropyl-CoM lyase
Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Function
Catalyzes the activation and addition of a nucleophilic thiol to the electrophilic epoxide substrate, which results in epoxide ring opening and the formation of an alcohol-nucleophile adduct.
Similarity
Belongs to the vitamin-B12 independent methionine synthase family.
Sequence
MLIRGEDVTIPTSMVGNYPNPRWWDAQFARTWTGDQEPPDALIQESLEDAVAAIARDQERAGLDIISDGRVHGDNYAEQALYYYYRRLGYDLKGGYLGFPIYSRLHAGTLTGEVRRHGAIMVEQAKALKKATGKPTKVQYTGVQALTQATNDLHYKSSRDRAMAIAKAINEDIREVDALGVDFIQIDEFTWPYFFEDWAIEAFNAAVDGVKNAKIIAHVCWGNWGGTPAYYPDETAASGEIFDLTKRKAEATKATATGSIVPKAYEARLDVLNLESCGRRSDDLSGLHVMKNHPLPDNVSFWAGVIDVKSTITETADEVANRIRRLLEIVPADRLGVTTDCGLILLQRYIAQDKLHALVEGTKIVRAELAKAKQAA