Protein
WD repeat-containing protein 1-A
Function
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin.
Similarity
Belongs to the WD repeat AIP1 family.
Sequence
MPYELKKVFASLPQMERGVAKILAGDPKGNNFLYTNGKSVIIRNIDNPAIADIYTEHAHQAVVARYAPSGFYIASGDTSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFASVFLWDTGSSVGEITGNIKVINSVDIKQTRPYRLVTGSDDNCCAFLEGPPFKFKFTMSDHSRFVNCVRFSPDGSKLASAGADGQIFLYDGKTGEKVCSLGGSKAHDGGIYAVSWSPDGTQLLSASGDKTTKIWDVAANSAVTTFNLGSDVLDQQLGCLWQKDYLLSVSLSGYINYLDKNNPARPLRVIKGHNKSIQCMTVNNSDGRSTIYTGSHDGHINYWDAETGENDTFTGKGHTNQVSSMDLDGCNQLITCSMDDTLRYTSLISKDYSSSESVKMDVQPKCVAVGSGGYVVTVCIGQIVLLKDKKKVFAIDSLDYEPEAVAIHKGSGTVAVGGADGKVHLYSIQGNSLKDEGKTLPAKGAVTDLAYSHDGAFLAVTDANKVVTVFSVADGYSEKNSYYGHHAKALSVAWSPDNEHFASSGMDMMVYVWTLSDPDTRIKMPDAHRLHHVSSLAWLDEHTLATVSHDACVKQWTVTFK