usp44-a

Gene

usp44-a

Protein

Ubiquitin carboxyl-terminal hydrolase 44-A

Organism

Xenopus laevis

Length

690 amino acids

Function

Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity).

Similarity

Belongs to the peptidase C19 family. USP44 subfamily.

Mass

79.011 kDa

Sequence

MDKCKHVGRLRLAQDHSILNPQKWHCVDCNTTESVWACLSCSHVACGRYIEEHALRHFQDSKHPLALEVNELYVFCYLCDDYVLNDNTTGDLKLLRSTLSAIKSQNYDCTTRSGRTLRSMVTADDSFISHEGAQAFLQNEDRAFTALWHRRHALLGKVFRSWFALTPKGKQRLEEERLREEAEQKREEARKKRQQLKRKLKEEMESTSPRKSSRLQHQIQPSPKTELPSVQKMNQKNSPTTKQKTPAPTSDKACFKKIGNSPIKRKPTVTPGVTGLRNLGNTCYMNSILQILSHLHVFRECFLQLDLNQTQELLAAAGSGKTRLSSKYPPGAELPRVTQKHTKVQRSLARRQSFSLGLSGGASNSRNMELIQPKEPSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQQELETTGTRYPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLVCDHKSNTIEPFWDLSLEFPERYHFNGKETASQRPCLLTEMLAKFTETEALEGKIYACDQCNKAQKQLMVCRLPQVLRLHLKRFRWSGRNHREKIGVHVRFDQMLNMEPYCCRESTAALRADCFIYDLSSVVMHHGKGFGSGHYTAFCYNPEGGFWVHCNDSKLHSCTVEEVCKAQAYILFYTQRVTQENGHLSDTLPVHGSPQSPPR

Protein

Ubiquitin carboxyl-terminal hydrolase 44-A: usp44-a