Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity).

Belongs to the peptidase C19 family. USP44 subfamily.

690 amino acids

MDKCKHVGRLRLAQDHSILNPQKWHCVDCNTTESVWACLSCSHVACGRYIEEHALRHFQDSKHPLALEVNELYVFCYLCDDYVLNDNTTGDLKLLRSTLSAIKSQNYDCTTRSGRTLRSMVTADDSFISHEGAQAFLQNEDRAFTALWHRRHALLGKVFRSWFALTPKGKQRLEEERLREEAEQKREEARKKRQQLKRKLKEEMESTSPRKSSRLQHQIQPSPKTELPSVQKMNQKNSPTTKQKTPAPTSDKACFKKIGNSPIKRKPTVTPGVTGLRNLGNTCYMNSILQILSHLHVFRECFLQLDLNQTQELLAAAGSGKTRLSSKYPPGAELPRVTQKHTKVQRSLARRQSFSLGLSGGASNSRNMELIQPKEPSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQQELETTGTRYPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLVCDHKSNTIEPFWDLSLEFPERYHFNGKETASQRPCLLTEMLAKFTETEALEGKIYACDQCNKAQKQLMVCRLPQVLRLHLKRFRWSGRNHREKIGVHVRFDQMLNMEPYCCRESTAALRADCFIYDLSSVVMHHGKGFGSGHYTAFCYNPEGGFWVHCNDSKLHSCTVEEVCKAQAYILFYTQRVTQENGHLSDTLPVHGSPQSPPR

79 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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