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upl-1

Gene
upl-1
Protein
E3 ubiquitin-protein ligase bre1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
724 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
82.276 kDa
Sequence
MPVATSPSAVPRPTTVKMEDRKRPAANADDVAPPSKRQAVNGTSKSKDDSNDSREEAWIEEYQKGAIYRQMLEYKRSKVDLEHRLQEAEKSAAFHDDHLRVIKYWLSQLTQELELIVEGSLKSIALKPVDSNWVSSLAFKDSKEFRQHLDDIKKPVILKVESLLNKLASSRGEVKPDVAQLEAQVKSLLANQKELAVKIDRLQAENATLSEQYDTATLKVIKAERKLDRVRSAQVQKLEQQALANSTTRQTTNDENGTSSIAENGDGAEYKTKYKEAIAVANKQKEQIESLLAEIKTLQEENASFKIKKEGISEEDYARTDVFKQFKAQNEDLIKRINNLEAVNKQFREDAEKLRAERTSYRATLEQEAQALTSDLEDQIQQKDQDLTRIRSARDELLAELAMRKASQEQEKTASAHLNELVEAMTDRVTQLESELERLRPTEDVAKAAPTDDLSTLSAEELREKFAKLERDYEAINKELPALEKSYRKAMGIAHKKVMDFTALEERVAILTAEKSKADQKYFAARKDMDIRIAEIRTLRGQNSKSSEIISQLKDVETQHRALITTLEKQIADLKQSNITIVTESKKLESLSSEATRRADSVKSQIENLQNLVKSKDTAGRELKEKAIDKEQEAEKLKVRLDKVSSERDKWKTKCQSNSTEEEEMLRNLVLCSVCRSNFKNTILKGCGHVFCNECVDNRLANRMRKCPSCNKAFDRSDAMPAHL