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tsp-12

Gene
tsp-12
Protein
Tetraspanin-12
Organism
Caenorhabditis elegans
Length
308 amino acids
Function
Together with tsp-14, regulates cell fate specification in the postembryonic mesodermal M lineage, body size and male development, probably by positively modulating BMP-like Sma/Mab signaling (PubMed:25978409, PubMed:28068334). May regulate BMP-like Sma/Mab signaling by mediating protease sup-17 trafficking to the cell surface (PubMed:28068334). Together with tsp-14, probably acts by modulating the activation of glp-1, a Notch-like receptor, to regulate germline maturation (PubMed:20220101). Probably acts by modulating the activation of lin-12, a Notch-like receptor, to regulate cell fate specification such as the anchor cell/ventral uterine precursor cell decision (PubMed:20220101).
Similarity
Belongs to the tetraspanin (TM4SF) family.
Mass
34.658 kDa
Sequence
MANRRQPVQHRAQQRVYRQSQIRYAPGAGGESEISCCVKYSVFSFNVIFFLLGFGLLLFGVWAQIEKNTFVNMLSKASKLYLDPTWPLLIVGFLTFIIGFSGCVGSLRENTSFLTFYSTLLGLLLIAEFSAGVFAYACRDQLDNYIRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSIEAREVASPEAGGVPFSCCINSSKLEFKNYFCGHGVRLKPESHMAAHLAAQRVMAHTASIYTEGCLPKLQLWLNNNMLLVAVSMVIIAIIQVLGICFAQNLKSDILAQRAKWYYTH