Protein
Toll-interacting protein A
Organism
Oncorhynchus mykiss
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
Similarity
Belongs to the tollip family.
Sequence
MSTTISTQRGQVYIGELPQDFLRITPTQQQQQVQLDAQAAQQLQYGGSLGTVGRLSITVVQAKLAKNYGMTRMDPYCRVRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHVTIPEGLREGSVVDEWYSLSLSGRQGDDKEGMINLVMSYANMPAGMHMSPPVVLMPTVYQQGVGYVPIAGVPTVYNQGMVPMGMPAAPTVAPQEAPCSEEDLKALQDMFPNLDKEVIRTVIEAQQGNKDAAINSLLQMTEEL