Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).

Belongs to the tollip family.

277 amino acids

MSTTISTQRGQVYIGELPQDFLRITPTQQQQQVQLDAQAAQQLQYGGSLGTVGRLSITVVQAKLAKNYGMTRMDPYCRVRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHVTIPEGLREGSVVDEWYSLSLSGRQGDDKEGMINLVMSYANMPAGMHMSPPVVLMPTVYQQGVGYVPIAGVPTVYNQGMVPMGMPAAPTVAPQEAPCSEEDLKALQDMFPNLDKEVIRTVIEAQQGNKDAAINSLLQMTEEL

30.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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