tbxta

T-box transcription factor T-A

423 amino acids

Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail formation. Required for the morphogenesis of Kupffer's vesicle and regulates left-right asymmetry.

45.834 kDa

MSASSPDQRLDHLLSAVESEFQKGSEKGDASERDIKLSLEDAELWTKFKELTNEMIVTKTGRRMFPVLRASVTGLDPNAMYSVLLDFVAADNNRWKYVNGEWVPGGKPEPQSPSCVYIHPDSPNFGAHWMKAPVSFSKVKLSNKLNGGGQIMLNSLHKYEPRIHIVKVGGIQKMISSQSFPETQFIAVTAYQNEEITALKIKHNPFAKAFLDAKERSDHKEVPDHSTDNQQSGYSQLGGWFLPSNGPMGPSSSPPQFNGAPVHSSGSYCERYSSLRNHRAAPYPSHYSHRSTTTNNYMDNSSGSLASHDSWSALQIPNSSGMGTLAHTTNTTSNTSQYPSLWSVAGTTLTPSGSASGSITGGLTSQFLRGSSMSYSGLTSSLPVSSPSSMYDPGLSEVGVGDAQFESSIARLTASWAPVAQSY