SPB1

AdoMet-dependent rRNA methyltransferase SPB1

921 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

105.145 kDa

MGKKQEKKTAKGRLDKFYWLAKEQGYRSRAAFKLVQLNKKFNFLEKARCCIDLCAAPGGWLQVASKFMPANSLIVGVDLVPIKPIPRTITFAEDINSYKCRDQLRQILKDWKADIVIHDGAPNVGTAWVQDAYAQSELTLQSLRLAVEFLTAGGTFVTKVFRSKDYNNLLWVFNQLFKKVEATKPSSSRNVSAEIFVVCQGYKNPARIDPKFLDPRHVFKELDPASLADQDQEAGVPLSLKGTSAGNAHANVFEPKKIRRNREGYADGDYTLFHSLDAMDFIKGQDVIGMLGSYNQISFESDESKKLLSLPDTNDEMRENCSDLKVLGKKDFRNLMNWRKEVRLALGIDLPKSKHQDLAEQTQTVEVEEMDEDDQIDDELARLNEEAARKARKERRRKNELRQKKILKMQLQMTTPMDIGMDVMDDQLGAGNGDMFEISSGERVSKKALIQQADVSDDESETIVSSQHTDDDDPETRARRLDAEMDALYDEFKQKQSERDAKFRAKQARLQDAKNDSWHGIKDDEENDEDDDEANLSDESEGGYDLVQRRKEQEETFDTDDEEDEEDERLEREATQHSKKRKRDLAAPTADSFEMDAKPPKRSLVHSLVSDADVSAQQSREASIWFDNPLFKDLELDEQDAQEALEDDQDDEDAWEEEQDDEDDAEESDSEVEGEQEVEDDDFEVVPQDQEEHAIPDEEWDLNGEDEEAGKQKRIKDHGLATAEAVALAQALVNRQITKEDLMDQGFSKHNFVDKDGLPTWFLDDEQKHYKANIPITKEAIQALRERQRALDARPIKKVAEAKARKKMRTLRRLEKAQKKAETINENEDISEKEKSNTINKLLAKSVKGAQKKKEVQLVVAKGVNRGLKGRPKGTKGRYKMVDPRMKKELRAFKRKAKRDGKKLGSSNSKPRVPKGYGPRN

SPB1

AdoMet-dependent rRNA methyltransferase SPB1

908 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

102.094 kDa

MGKHDKKTGKGRLDKFYRLAKEQGYRARSAFKLVHLNRKYDLLSKARCCIDLCAAPGGWLQVAEKYMPKGSLIIGVDLNAIKPLPHVTTFVADITTPHCRQTLRQHMHDWKADLVLHDGAPNVGSAWVQDAFTQNELVLQSLKLATEFLAKGGSFVTKVFRSQDYNSLLWVFGQLFKSVEATKPPSSRNVSAEIFVVCRDFIAPKHIDPKFLDPKHVFKDIASLPTSITEPTDTSIAPTSSSTASAAAAAARLAANSHAHSNVYAPEKKRRHREGYAEGDYTLHHTASAEEFVRGQDPVLLLGNMNKIEFRNETEKGWLKSRHTTPDIIANFEDLKVLGKGDFKALMKWRLAIRLEIGLDVKADKTQDATEEVVVEPMDEEEQITEELQKLQQAKLAKTKRERKRANEKKARELLKLQLNMTVPDDLDQNDLALQGEEEIFDLEEGENEARRRGKNGGLATLVDDGEGMDLASESEEEEDEDEEDDEVLDSDEERERKTAALEGELDGLYDSYVERKKERDAKWKVKQDRLKDKNFDAWHGIQEKSDEEGSDDDDGQDDDEEGGWDVIAQKKAKYGEGDSSDSDSDAEPETEVPKKIKKVSFEKPARSEKSSGLMTSLREPELRAQRSKQAQLWFDQPVFKEVGDLAALDGDDEEEEEEDESEEEESDDEDVDMEDASESSSTLEGDDDFEIVPQAPEDDGPEWDVDDEDQDEVKKKVIQDKGLLTAEAVSLATALVNRKTTADKLIDQGFNRLSAHNKDGLPTWFLDDESQFYKPNIPITKEAVDALRARQRALDARPIKKVAEAKGRKKMKAVARMEKAKKKADGVMESEEMGDGEKARQVRRMLARAAKGKEKAKEKKIVVAKGVNKGVKGRPTGVKGKYKIVDARMRKEVRALKRIKKAGSKRR

SPB1

AdoMet-dependent rRNA methyltransferase SPB1

908 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

102.094 kDa

MGKHDKKTGKGRLDKFYRLAKEQGYRARSAFKLVHLNRKYDLLSKARCCIDLCAAPGGWLQVAEKYMPKGSLIIGVDLNAIKPLPHVTTFVADITTPHCRQTLRQHMHDWKADLVLHDGAPNVGSAWVQDAFTQNELVLQSLKLATEFLAKGGSFVTKVFRSQDYNSLLWVFGQLFKSVEATKPPSSRNVSAEIFVVCRDFIAPKHIDPKFLDPKHVFKDIASLPTSITEPTDTSIAPTSSSTASAAAAAARLAANSHAHSNVYAPEKKRRHREGYAEGDYTLHHTASAEEFVRGQDPVLLLGNMNKIEFRNETEKGWLKSRHTTPDIIANFEDLKVLGKGDFKALMKWRLAIRLEIGLDVKADKTQDATEEVVVEPMDEEEQITEELQKLQQAKLAKTKRERKRANEKKARELLKLQLNMTVPDDLDQNDLALQGEEEIFDLEEGENEARRRGKNGGLATLVDDGEGMDLASESEEEEDEDEEDDEVLDSDEERERKTAALEGELDGLYDSYVERKKERDAKWKVKQDRLKDKNFDAWHGIQEKSDEEGSDDDDGQDDDEEGGWDVIAQKKAKYGEGDSSDSDSDAEPETEVPKKIKKVSFEKPARSEKSSGLMTSLREPELRAQRSKQAQLWFDQPVFKEVGDLAALDGDDEEEEEEDESEEEESDDEDVDMEDASESSSTLEGDDDFEIVPQAPEDDGPEWDVDDEDQDEVKKKVIQDKGLLTAEAVSLATALVNRKTTADKLIDQGFNRLSAHNKDGLPTWFLDDESQFYKPNIPITKEAVDALRARQRALDARPIKKVAEAKGRKKMKAVARMEKAKKKADGVMESEEMGDGEKARQVRRMLARAAKGKEKAKEKKIVVAKGVNKGVKGRPTGVKGKYKIVDARMRKEVRALKRIKKAGSKRR

SPB1

AdoMet-dependent rRNA methyltransferase SPB1

865 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

97.501 kDa

MAIQKKHGKGRLDKWYKLAKEKGYRARAAFKLIQLNKKYGFLEKSKVLLDLCAAPGSWCQVAAEVMPVSSLIVGVDLAPIKPIPKVITFQSDITTEKCRATIRQHLKTWKADTVLHDGAPNVGTAWVQDSFNQAELTLQAMKLATEFLVEGGTFVTKVFRSKDYNSMLWVFNQLFKKVEATKPPSSRNVSAEIFVVCRGFKAPKRIDPKFLDPRAVFAELADPTPNNEAKVYKPEIKKRKRDGYEEGDYTQYKELPAYEFIQSTDPIAILGSTNRLSLEQSKNGDVALAVLEKLPETTDEIRTCCADLKVLGRKEFKLLLKWRLAVREKLGFPTKKSVKKEEEAAAAVAAAEEVAKIESMDEEMRIQHELEKLKERNSTKKKRERRKENERKQKDIVRMQMHMVAPMDIGVEQAGPEGEDAMFALRAVEKGDVMRRLAKGKMVVASEADAKKDRDSGIGSSGETDDESDEELDRLETELDDMYDQFRERKAASDAKYRAKKARQARNGDGDEEWEGVSDNEKADEISDDSELEEESSGDSDDEDDTAPRKSLLTDLDTTPSDNSGLSKRARAFFNQDIFKELDGDMDEPMDEELRAALAGEDEDADMEDTVSKADSKKTKEKTADKKAAKKAKKAAQKAQQVKDDDSDDESDGGFEVVKSGKEDDWEDEDKRTKDGRLDIDIITAEAMTLAHQLATGQKSSHDVIDDGFNKHAFKDREGLPEWFLDDETKHDKPQKPITKAAAAAIKEKMRAFNARPIKKVREAKGRKKMKAAQRLEKLKKKSDLLVNEEGMTEKEKAESIAKLLRKATKKKPKQAVKVVVAKGANRGIKGRPQGIKGRYKIVDPRMKKEMRALKRVAQKAKKRR

SPB1

AdoMet-dependent rRNA methyltransferase SPB1

850 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

97.467 kDa

MGKIQKKHGKGRLDHYYRLAKEKGYRARSSFKIIQINQKYGKFLEKSKVVIDLCAAPGSWCQVASQLCPVNSLIIGCDIVPIKPLPNVITFQSDITTDHCRQQLRQYMKTWKADTVMHDGAPNVGMAWAQDAFTQSELVLQSLKLAVEFLNKGGTFVTKVFRSKDYNNLMWVFQQFFEKVEATKPPSSRNVSAEIFVVCLKFKAPKKIDPRLLDAKYVFEEVSQGNNNNEAKVFNPEVKRRKREGYEEGEYLQHKRLSILDFITDSTPIDNLGETNEMTWTPRSIKEGEVDEEEEKEKDKEARDERGNVQYVLDDKVYSDEDALKMVSKLPQTTPELLECLKDLKVLGRKEFRAILKWRLSARDLLQIDKPEAGVEVEEEELDEDQLIDKELSELGEREKARKKRERRRRNEMKQREIQRMQMNMTTPTELGIEAAKMESLFNLKQAERTGKLSELQKGKRSHVSETGDEHVTLEEAERVDYGSDDEANGLEDELESMYTEYLENKAARTAKSVVQRKKANVETEEWFGISDKKDGDESDGEMSADDVDMATIDDGEDEDDGKTARTLNNGNMFFSNPIFDNLVNAAVAKTEAKPKALDLLEPGAKDLIELEKAKKRKYAKKNGLEYSDSEDEEDDIVMETQKQDDSDIEYVHGESDSDDEPNIDLVTDQAMTMAHQLATGQTNKHKLQDDGYNRYSFRDLDGLPQWFQDDENKHNKLNKPITKEAVEALKQKMKTLNARPIKKVLEAKGRKKMRALRRLEQMKKKSELINEDGARSEKEKADDISKLMRKLAKPQKSKKKTVTVVYAGGKNKGIAGRPRGVTGKYKMVDGTMKKEQRAIRRIKKKMGKK

SPB1

AdoMet-dependent rRNA methyltransferase SPB1

845 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

96.82 kDa

MGKQQKKHSKGRLDRYYYLAKEKGYRARSSFKIIQINEKYGHFLEKSKVVIDLCAAPGSWCQVASQLCPINSLIIGVDIVPIKPLPNVITFQSDITTEDCRSRLRGHMKTWKADTVLHDGAPNVGLGWVQDAFTQSQLTLQALKLAVENLTAGGTFVTKIFRSRDYNNLMWVFQQLFEKVEATKPPASRNVSAEIFVVCKGFKAPKKLDPRLLDPKEVFEELGGGNESKQNNEAKIFNPEKFSSQRQRQGYQEGDYTLFHTMPIMDFIKQDDPINQLGSLNKFDLPAPKDDDNDDDDHDHEWKILSKLKLCTPELLECIKDLKVLGRKEFKMILKFRKQARDILGIDKDEKEEEEENPKIEVEPLTEEQKIDQELQDLINKQKQKAKRLKKNANELKQKEIIRNQMNMLTDMNIGIEAAQIGADSLFNLKTAEKTGQLDKLAKGKKKMIFNDEELAKDNEIHIDEEEINDNDKDSADELDELENQLDDMYHQYQARKAERDANYRAKQARGDADDEAWNGIEEDNDDVESGKDYEMESESDDDDDEHIRLIAEKKSNGSLSRTARNFFASDSIFNELSDDVILEEIENKTKGSNGKMVESIQEQVANDNNENDDGDNDEEESDFEIVPNQKSDDDDDDESMNSDDDEVSTTTKSTTHQQKVDLATVEAMTLAHQVALGQKNKYDLIDEGINRYSFRDKDNLPDWFIDDEKKHSKLIKPITKEAAIAIKEKQKQLNARPIKKVLEAQSRKKLRALKRLEKIKKKSDLINEDSGKSERDKADEISKLMKKLNKKQKQKPKTTVVVARGSNRGLSGRPKGVKGKYKMVDGVMKNEQRALKRIAKKYKK

SPB1

27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase

841 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

96.485 kDa

MGKTQKKNSKGRLDRYYYLAKEKGYRARSSFKIIQINEKYGHFLEKSKVVIDLCAAPGSWCQVASKLCPVNSLIIGVDIVPMKPMPNVITFQSDITTEDCRSKLRGYMKTWKADTVLHDGAPNVGLGWVQDAFTQSQLTLQALKLAVENLVVNGTFVTKIFRSKDYNKLIWVFQQLFEKVEATKPPASRNVSAEIFVVCKGFKAPKRLDPRLLDPKEVFEELPDGQQNMESKIYNPEKKVRKRQGYEEGDNLLYHETSILDFVRTEDPISMLGEMNKFTIDENDHEWKILKKLKQTTDEFRSCIEDLKVLGKKDFKMILRWRKIAREILGIEVKDDAKTEIEVVPLTEEEQIEKDLQGLQEKQRLNVKRERRRKNEMKQKELQRMQMNMITPTDIGIEAASLGKESLFNLKTAEKTGILNDLAKGKKRMIFTDDELAKDNDIYIDENIMIKDKDSAADADDLESELNAMYSDYKTRRSERDAKFRAKQARGGDNEEEWTGFNEGSLEKKEEEGKDYIEDNDDEGVEGDSDDDEAITNLISKLKGQEGDHKLSSKARMIFNDPIFNNVEPDLPVNTVNDGIMSSESVGDISKLNKKRKHEEMHQKQDEADSSDESSSDDSDFEIVANDNASEEFDSDYDSEEEKNQTKKEKHSRDIDIATVEAMTLAHQLALGQKNKHDLVDEGFNRYTFRDTENLPDWFLEDEKEHSKINKPITKEAAMAIKEKIKAMNARPIKKVAEAKARKRMRAVARLEKIKKKAGLINDDSDKTEKDKAEEISRLMRKVTKKPKTKPKVTLVVASGRNKGLAGRPKGVKGKYKMVDGVMKNEQRALRRIAKKHHKKK

SPB1

AdoMet-dependent rRNA methyltransferase SPB1

837 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

96.099 kDa

MGKTQKKNSKGRLDRYYYLAKEKGYRARSSFKIIQINEKFGHFLEKSKVVIDLCAAPGSWCQVASKLCPVNSLIIGVDIVPMKPMPNVITFQSDITTEDCRSRLRGYMKTWKADTVLHDGAPNVGLGWAQDAFTQSHLTLQALKLAVENLVVNGTFVTKIFRSKDYNKLIWVFQQLFEKVEATKPPASRNVSAEIFVVCKGFKAPKKLDPRLLDPKEVFEELPDGPQNMEAKIYNPEKKVRKRQGYEEGDHLLYHECSVLDFVKSEDPITVLGEMNKFTVEQDDPEWKILKRLKQTTNEFMACIEDLKVLGKKDFKMLLKWRKASRDILGLDKDEDKGDIEIEPLNEEEQIEKELRDLQEKQKQKQKREKRRKNEEKQKELTRMQMNMLTPTDIGIEAANIGRDSLFNLKTAEKTGILDKLAKGKKRVIFTEDEIAQDNDLHIDENIVIRDRHDMNEVDDLEGELNAMYQDYKNRKAERDANFRAKQARGGDVEDEWTGFEGTKDSEDENNEPKDYIESDDSELSDEDDDEAINQLISKLKSQNNGSKLSSQAKALFSNPLFENVQPILQSKTDDVVDSESVGDATKISNKRSYNEMKKEDLSDSSDEDSSSESDFEIVANDESDGDIDSDYDSDEERKRTTKEKYDKDIDIATVEAMTLAHQLALGQRSKHDLVDEGFNRYAFRDTENLPEWFLEEEKQHSKVNRPITKEAVMALKEKMKALNARPIKKVAEARARKKMRAVKRLEKIKKKAGLINDDSDKSEKDKAEEIAKLMRKVTKKQKTKPKVTLVVAHGKNKGLSGRPKGIKGKYKMVDGVLKNEQRALKRIAKKHHKKKK

SPB1

AdoMet-dependent rRNA methyltransferase SPB1

833 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

95.282 kDa

MGKKTQKKNSKGRLDKYYYLAKEKGYRARSSFKIIQINEKYGHFLEKSKVVIDLCAAPGSWCQVASNLCPVNSLIIGVDIVPMKTMPNVITFQSDITTEDCRSKLRGYMKTWKADTVLHDGAPNVGLSWAQDAFTQSHLTLQALKLAVENLVVGGTFVTKIFRSKDYNKLIWVFQQLFEKVEATKPPASRNVSAEIFVVCKNFKAPKKLDPRLLDPKEVFEELPDGPQNMEAKVFNPEKKVRKRGGYEEGDYLLYHETGLMDFMKSEDPITMLGEYNKFIVDEEDHDWKIVKKLKQTTKEFLACIEDLKVLGRKDFKMILKWRKAARELLGLDEEEEKPEIEETPLTEEEQIEKELNTLQEKQRLSVKREKRKKNEMKQKEIVRMQLNMINPVDIGIEAAELGRESIFNLKTAEKTGILDKLAKGKRRMIFDQNELAIDNDIHIDENAPLDDRDELAEADELESQLDAMYSNYKERKSERDAKFRAKQARESSEADNWNGFEDKQSDEENEEETKDYVDDDDNSDLSDSDDDEAINQLIAKLKSRENSSKLSSKARALFSDSLFEGVEPDLPGKADLADSESVGDVKQLTKKRKLNPLPAEQISEAESSDEDSDFEIVANNEDGDVDSEYDSEEEAKRTKQEKHSKDIDIATVEAMTLAHQLALGHKTKHDLIEEGFNRYSFRDMENLPEWFVEEEKQHSKINKPITKEAAMAIKDKLKALNARPIKKVAEAKARKKHRAVARLEKLKKKAGLINDDSDKSEKDKAEEIAKLMRKVTKKAKQKPKVTVVVASGKNRGLSGRPKGVKGKYKMVDGVLKNEQRALKRIAKKHHKK

SPB1

AdoMet-dependent rRNA methyltransferase SPB1

831 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

95.072 kDa

MGKTQKKNSKGRLDRYYYLAKEKGYRARSSFKIIQINEKYGHFLEKSKVVIDLCAAPGSWCQVASQLCPINSLIIGVDIVPIKALPNCITFQSDITTEDCRSQLRGHMKTWKADTVLHDGAPNVGLGWVQDAFTQSHLTLQALKLAVENLNTGGTFVTKIFRSRDYNNLMWVFQQLFEKVEATKPPASRNVSAEIFVVCKGYKSPKKMDPRLLDPREVFEELPTGPDNNEAKIFNPEKKVRRRQGYEEGDYTLFHEMPLLEFIKNEDPINTLGTLNKLSEPPQDDHEWKILKKSKLCTPELLECIKDLKVLGRKDFKHLLKFRKQARDLLGLDAKEETQEIEVEPLTEDQQIEKELQELTEKQKQKARKAKKQSNEIKQKEIQRSQMNMLTDMNIGIEAAQIGAESLFNLKTAIKTGQLEKLSKGKKKMIFNDEEIMKDNDINFDEEADANSEDEIDELEAQLDDMYNSYQNRRAERDANYRAKKLRGDVDDEGWEGIESDKEGSDKETEANDYEMESESDSDDDEHIQRIADQRKKELSKNAKVFFASNSIFGELGDEALLEEMNKKEAKTNQVTNENAVGHANDISNKPEQMEVDSSDSENDVSDDSDFEIVPNAPDEELSDSDSDNENDVSRKYSKAKDQQSKVDIATVEAMTLAHQVALGHKNKHDLVNEGIHKYSFRDHDDLPEWFVDDEKRNSKIVKPITKEAALAIKEKQKQLNARPIKKVLEAQGRKKLRALKRLEKLKKKSDMINEDSAKSERDKADEIQKLMKKLTKKQKTKPKATLVVARGSNRGLSGRPKGVKGKYKMVDGVMKNEQRALKRIAKKHKK

spb1

AdoMet-dependent rRNA methyltransferase spb1

831 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

93.958 kDa

MAIQKKHGKGRLDKWYKLAKEKGYRARAAFKLIQLNKKYGFLEKSKVALDLCAAPGSWCQVCAETMPTNSIIIGVDLAPIKPIPKVITFQSDITTEKCRATIRSHLKTWKADVVLHDGAPNVGTAWVQDSYNQAELALHSLKLATEFLIEGGTFVTKVFRSKDYNSLLWVCNQLFAKVEATKPPSSRNVSAEIFVVCRGFKAPKRIDPKLLDPRSVFEDVAGPAPNNEAKVYNPEVKKRKREGYEEGDYTQFKEISASEFINTVDPIAILGQYNKLSFEQPKNGDVALAALDKLPETTEEIRLCCADLKVLGRKEFKLLLKWRLKVREIFGFPSKKTQKAAVDEEVAVVENMDEELRIQEELQRIKEKETSKKKRERRRENEKKQKEIVRMQMNMTAPMDIGVEQEGPRGEGAMFRLKTIDQNAALNKIAKGKMAVIKETEKPKDYDFGSDGETDESDEEADRLEEELDNLYDQYRERKAAADAKYRAKKARKENGDDEWEGVSGDEEKGSDDDDDEELEVDSSDDDSDSEDGESGKKLITDLDGQPEEKDGLSKRAKNFFSQGIFAEIPGLLEEPESEEEEAQEAELVEAVEDLKVTKKEKKEAKETKAKSKKAAEESDDDDDFEVVKNNEDDDWENVEKKKKNGRPDIDIITAEAMTLAHQLATGEKTSYDVIDDGYTKHAFKDRDGLPDWFLDDESKHDKPHKPITKAAAQAIKEKLRAYNARPIKKVAEAKARKKFKQAQRLEKLKKKADMLAGDDGMSEKEKAASISKLMASVAKKTRRAPIKVVKAAGSNKGLQGRPKGVKGRYKMVDPRMKKELRAMKRISKKK

SPB1

AdoMet-dependent rRNA methyltransferase SPB1

830 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

94.998 kDa

MGRTQKKNSKGRLDRYYYLAKEKGYRARSSFKIIQINEKFGHFLEKSKVVIDLCAAPGSWCQVASNLCPVNSLIIGVDIVPMQPMPNVITFQSDITTEDCRSKLRGYMKTWKADTVLHDGAPNVGLNWVQDAFTQSHLTLQALKLAVENLVVGGTFVTKIFRSKDYNKLMWVFQQLFDKVEATKPPASRNVSAEIFVVCKGFKAPKKLDPRLLDPKEVFEELPDGPQNMQAKVYNPEKKTRKRDGYEEGDYLLYHTVPIMDFVKVEDPIQMLGTTNKFTLDKDDHEWKIVKKLKQTTPEFKACIEDLKVLGKKDFKMLLRWRKAARELLGLDKDEEQPEIETVPLTEEEQIEKELQEMQQKQNLKKKREKRKQNEIKQKEITRMQMQMITPTDLGIEAASIGRDSLFNLKTAEKTGILDDLARGKKRMVFTRDELAEDNEIQIDENAPLSDRDDLADADELESQLDAMYHQFKARRIERDAHFKAKEARGGDDDAWNGFDEVASDEEPEESKKDYVDDDDSDVSDSDSDEAINQLIAKIKGETGDKKLSAKARALFNDSIFDGVEADLPSEEPQAPASSEQGSKKRRLEEVSEESSSDEEEAEEESDSDFEIVRNEKDESDDDYDSEDEAERSQKEKHAREVDIATVEAMTLAHQLALGQRSKHDIVDEGFNRYSFRDRDNLPEWFLEDEKMHSKINKPITKEAAMAIKEKLKALNARPIKKVAEAKARKKMRALNRLEKLKKKAGLINDDSDKSEKDKAEEIAKLMKKVTKKAKLKPKVTLVVAKGKNRGLSGRPKGIKGKYKMVDGVMKNEQRALKRIAKKHRKKSKH

spb1

AdoMet-dependent rRNA methyltransferase spb1

806 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

91.369 kDa

MAIQKKHGKGRLDKWYRLAKEKGYRARAAFKLVQLNKKYGFLEKSKVLLDLCAAPGSWCQVAAECMPAQSLIVGVDLAPIKPIPRVITFQQDITTEKCRATIRSHLKHWKADTVLHDGAPNVGTAWVQDAFSQAELVLESLKLATEFLVEGGTFVTKVFRSKDYNPLLWVFKQLFMSVEATKPPSSRNVSAEIFVVCRGYKAPKRIDPKFLDSKHVFAELADPTPNNEAKVFNPEKKKRKREGYEEGDWTQFKEIPVTEFINTTDPIAILGSCNKLSFQQQPGGDLALATLDRLPETTDEIRNCCEDLKVLGKKEFRNLLRWRLKVREKFGLVVKKGQAKDDEAEEVAEIAPMDDELAIQEELLRLKEKESARSKKERRKENERKRKEIVRMQMHMTTPMDIGMEQLGPGGEDATFSLKRAEKAGAAAAMASGKELAVIESESEESESETEYDDSDDEGDRLERELDSLYEQYQERKEDKDSKLRAKKARKDYEADEWEGFSDSDKEGSDDEEDEAKPNVPVVPTNGALSNNAALFFDQDIFQGLDDVEDEEDEAEGTNNMTVANEREEQQEEEEEEQPKSEAAPEKKKKVKETANSKPSEDSSDDEYEDTDEPRKKNGQLDIDIITAEAMALAQQMATGEKKSQDVFDDGFNRYAFRDVDGLPEWFLDDENKHSKPNRPITKAAAAAIQEKWRAINARPIKKVMEAKGRKKFKAAQRIEKLRKKSALLADDETMSERDKAQAIARMMSRAAKKKPKQNVKLVVAKGGNRGISGRPKGVKGKYKIVDARMKKDVRAQKRLAKKKQK

spb1

AdoMet-dependent rRNA methyltransferase spb1

802 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

90.906 kDa

MGKSQKKTAKGRLDKWYKLAKEQGYRSRAAFKLVQLNQKYSFLEKAKVIIDLCAAPGGWLQVASKTCKPGSLIVGVDLAPIKPIPNCHTFVEDITSDKCRSQLRGYLKTWKADVVLHDGAPNVGSAWLQDAYGQAQLVLMSMKLACEFLVAGGTFVTKVFRSRDYNNLLWVFKQLFNKVEATKPPSSRNVSAEIFVVCRGYKAPKKLDPRFTDPRTVFEEVQEPVTNVDAKVFHPEKRKRSREGYADDDYTLHKTVLASEFVTANDPIQILGTSAEIVFPKDDEECQRLYNLDVTTEEILLCCSDLQVLGKKEFRDILRWRLKIRDEMGIGKKVEDEQKTVVEEIPEMDEEERLDQELQDLSEAERVKLKRERRKANQRKQREIVRMQMGMLAPMDIGLEHEAMGEDSLFGLATAEKHGLKELENGTLPVTESVDEEVSTDNEVEYDSDDERDRLEADLDSMYSDYTKRKAESDVKYRVKKARGDLDDEEWNGIDNGTESDDSQIAETNFATPDKDRLTTSLLDKGSTKDGLSRKARMFFDQDIFDGIEDADADVEIMSMNRAAIKKREAELASQNNDDGSKGDQSEDSNDHIEVVPVASAHDEDDDWNSDSDNDENNVEIVTAEAMTLAQDIASRRKSKADLIDEGYNRWSFQSKEGLPDWFLDEETTVNKPNKPITKEAVLALREKMKALNARPIKKVLEAQGRKKMRTIKRLQRVAKKAEGISESGDMTESEKAKEISRLVSRATKSKPKAKPTLVVAKGPNKGLKSRPKGVKGKYKMVDSRMKKDLRAQKRLAKKGRR

spb1

AdoMet-dependent rRNA methyltransferase spb1

795 amino acids

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.

90.115 kDa

MAIQKKHGKGRLDKWYRLAKEKGYRARAAFKLIQLNKKYGFLEKSKVLLDLCAAPGSWCQVAAECMPTQSIIIGVDLAPIKPIPRVITFQSDITTEKCRATIRQHLKHWKADTVLHDGAPNVGTAWVQDAFSQAELVLQSMKLATEFLVEGGTFVTKVFRSKDYNPLLWVFKQLFTSVEATKPPSSRNVSAEIFVVCRGFKAPKRIDPKFLDPKHVFAELTDSTPNNEARVFNPEKKKRKREGYEEGDYTQFKEIPVTEFINTTDPIAILGTYNKLSFEQSPGGDLALATLNRLEETTDEIRTCCEDLKILGKKEFRSLLRWRLKVREKFGLVVKKGQAKADEPEEVAEVAPMDEELAIQEELQRLQEKESAKRKKERRKENEKKRKEIIRMQMHMTTPMDIGMEQLGPGGDDATFSLKRVERDGARDVIASGKLAEIESDSEDDQTESDYDESDDEGDRLERELDSLYEQYQERREDRDSKVRAKKARKDYEAEEWDGFSDSDKEDDEESEEDGASQAVVKPAPPNSGTLSSKAAMFFDQDIFQGLGDVDDVEDEDSAIEMQEDDKSAKKGSALEKKAPKEAKKKAQAPEDFSDSDPEEPDDPRKKNGQLDIDIITAEAMALAQQMATGEKKSQDIIDDGFNRYTFRDVDGLPEWFLDDENKHSKPQRPITKAAAAAIKEKLRAINARPIKKVMEAKGRKKMKAAQRLEKLRKKSALLADDEALSERDKSQAIAKLMSKAVKKKPKQQVKLVVARGANRGISGRPRGVKGKYKIVDSRMKKDIRAQKRLAKKKK