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sopE

Gene
sopE
Protein
Guanine nucleotide exchange factor SopE
Organism
Salmonella enterica VII
Length
240 amino acids
Function
Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).
Similarity
Belongs to the GEF (guanine exchange factor) SopE family.
Mass
26.526 kDa
Sequence
MTKITLSLQNFRIQKQETTPLKEKSTEKTSLAKAILAVKNHFNKLSSNLSERFISHKNTESSATHSHRGSASADRAVLTNKVVKEFMLQTLNDMDIRGNASKDPAYASQTREAILSAVYSKNKDQCCKLLISKGINIAPFLKEIGEAAQNAGLPGATKNDVFTPSGAGANPFITPLVSSANCKYPHMFINQHQQASFKIYAEKIIMTEVAPLFNECVMPTPQQFHLILENIANKYIQNTP
Protein
Guanine nucleotide exchange factor SopE: sopE

Gene
sopE
Protein
Guanine nucleotide exchange factor SopE
Organism
Salmonella enterica I
Length
240 amino acids
Function
Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).
Similarity
Belongs to the GEF (guanine exchange factor) SopE family.
Mass
26.685 kDa
Sequence
MTKITLSPQNFRIQKQETTLLKEKSTEKNSLAKSILAVKNHFIELRSKLSERFISHKNTESSATHFHRGSASEGRAVLTNKVVKDFMLQTLNDIDIRGSASKDPAYASQTREAILSAVYSKNKDQCCNLLISKGINIAPFLQEIGEAAKNAGLPGTTKNDVFTPSGAGANPFITPLISSANSKYPRMFINQHQQASFKIYAEKIIMTEVAPLFNECAMPTPQQFQLILENIANKYIQYTP
Protein
Guanine nucleotide exchange factor SopE: sopE

Gene
sopE
Protein
Guanine nucleotide exchange factor SopE
Organism
Salmonella gallinarum
Length
240 amino acids
Function
Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).
Similarity
Belongs to the GEF (guanine exchange factor) SopE family.
Mass
26.751 kDa
Sequence
MTKITLFPHNFRIQKQETTPLKEKSTEKNSLAKSILAVKNHFIKLNSKLSERFISHKNTESSATHFHRGSASEGRAVLTNKVVKNFMLQTLHDIDIRGSASKDPAYASQTREAILSAVYSKYKDQYCNLLISKGIDIAPFLKEIGEAAQNAGLPGATKNDVFTPSGAGANPFITPLITSAYSKYPHMFTSQHQKASFNIYAEKIIMTEVVPLFNECAMPTPQQFQQILENIANKYIPNTP
Protein
Guanine nucleotide exchange factor SopE: sopE

Gene
sopE
Protein
Guanine nucleotide exchange factor SopE
Organism
Salmonella hadar
Length
240 amino acids
Function
Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).
Similarity
Belongs to the GEF (guanine exchange factor) SopE family.
Mass
26.752 kDa
Sequence
MTKITLFPHNFRIQKQETTPLKEKSTEKNSLAKSILAVKNHFIKLNSKLSERFISHKNTESSATHFHRGSASEGRAVLTNKVVKNFMLQTLHDIDIRGSASKDPAYASQTREAILSAVYSKYKDQYCNLLISKGIDIAPFLKEIGEAAQNAGLPGATKNDVFTPSGAGANPFITPLITSAYSKYPHMFTSQHQKASFNIYAEKIIMTEVVPLFNECAMPTPQQFQQILENIANKYIQNAP
Protein
Guanine nucleotide exchange factor SopE: sopE

Gene
sopE
Protein
Guanine nucleotide exchange factor SopE
Organism
Salmonella houtenae
Length
240 amino acids
Function
Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).
Similarity
Belongs to the GEF (guanine exchange factor) SopE family.
Mass
26.537 kDa
Sequence
MTKITLSLQNFRIQKQEITPLKEKSTEKTSLAKAILAVKNHFNKLSSNLSERFISHKNTESSATHSHRGSASEDRAVLTNKVVKEFMLQTLNDMDIIGNASKDPAYASQTREAILSAVYSKNKDQCCKLLISKGINIAPFLKEIGEAAQNAGLPGATKNDVFTPSGAGANPFITPLVSSANSKYPHMFINQHQQASFKIYAEKIIMTEVAPLFNECVMPTPQQFHLILENIANKYIQNTP
Protein
Guanine nucleotide exchange factor SopE: sopE

Gene
sopE
Protein
Guanine nucleotide exchange factor SopE
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Length
240 amino acids
Function
Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).
Similarity
Belongs to the GEF (guanine exchange factor) SopE family.
Mass
26.713 kDa
Sequence
MTKITLSPQNFRIQKQETTLLKEKSTEKNSLAKSILAVKNHFIELRSKLSERFISHKNTESSATHFHRGSASEGRAVLTNKVVKDFMLQTLNDIDIRGSASKDPAYASQTREAILSAVYSKNKDQCCNLLISKGINIAPFLQEIGEAAKNVGLPGTTKNDVFTPSGAGANPFITPLISSANSKYPRMFINQHQQASFKIYAEKIIMTEVAPLFNECAMPTPQQFQLILENIANKYIQYTP
Protein
Guanine nucleotide exchange factor SopE: sopE

Gene
sopE
Protein
Guanine nucleotide exchange factor SopE
Organism
Salmonella typhi
Length
240 amino acids
Function
Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).
Similarity
Belongs to the GEF (guanine exchange factor) SopE family.
Mass
26.685 kDa
Sequence
MTKITLSPQNFRIQKQETTLLKEKSTEKNSLAKSILAVKNHFIELRSKLSERFISHKNTESSATHFHRGSASEGRAVLTNKVVKDFMLQTLNDIDIRGSASKDPAYASQTREAILSAVYSKNKDQCCNLLISKGINIAPFLQEIGEAAKNAGLPGTTKNDVFTPSGAGANPFITPLISSANSKYPRMFINQHQQASFKIYAEKIIMTEVAPLFNECAMPTPQQFQLILENIANKYIQYTP
Protein
Guanine nucleotide exchange factor SopE: sopE

Gene
sopE
Protein
Guanine nucleotide exchange factor SopE
Organism
Salmonella typhimurium
Length
240 amino acids
Function
Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates MAPK8, indicating that it is capable of stimulating signaling pathways that can lead to nuclear responses. Chaperone InvB is required for secretion and translocation of SopE.
Similarity
Belongs to the GEF (guanine exchange factor) SopE family.
Mass
26.636 kDa
Sequence
MTKITLSPQNFRIQKQETTLLKEKSTEKNSLAKSILAVKNHFIELRSKLSERFISHKNTESSATHFHRGSASEGRAVLTNKVVKDFMLQTLNDIDIRGSASKDPAYASQTREAILSAVYSKNKDQCCNLLISKGINIAPFLQEIGEAAKNAGLPGTTKNDVFTPSGAGANPFITPLISSANSKYPRMFINQHQQASFKIYAEKIIMTEVAPLFNECAMPTPQQFQLILENIANKYIQNTP
Protein
Guanine nucleotide exchange factor SopE: sopE

Gene
sopE
Protein
Guanine nucleotide exchange factor SopE
Organism
Salmonella dublin
Length
240 amino acids
Function
Acts in concert with other proteins to mediate cellular responses leading to bacterial internalization. Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).
Similarity
Belongs to the GEF (guanine exchange factor) SopE family.
Mass
26.738 kDa
Sequence
MTKITLFPHNFRIQKQEATPLKEKSTEKNSLAKSILAVKNHFIKLNSKLSERFISHKNTESSATHFHRGSASEGRAVLTNKVVKNFMLQTLHDIDIRGSASKDPAYASQTREAILSAVYSKYKDQYCNLLISKGIDIAPFLKEIGEAAQNAGLPGATKNDVFSPSGAGANPFITPLITSAYSKYPHMFTSQHQKASFNIYAEKIIMTEVVPLFNECAMPTPQQFQQILENIANKYIQNTP
Protein
Guanine nucleotide exchange factor SopE: sopE