Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).

Belongs to the GEF (guanine exchange factor) SopE family.

240 amino acids

MTKITLFPHNFRIQKQETTPLKEKSTEKNSLAKSILAVKNHFIKLNSKLSERFISHKNTESSATHFHRGSASEGRAVLTNKVVKNFMLQTLHDIDIRGSASKDPAYASQTREAILSAVYSKYKDQYCNLLISKGIDIAPFLKEIGEAAQNAGLPGATKNDVFTPSGAGANPFITPLITSAYSKYPHMFTSQHQKASFNIYAEKIIMTEVVPLFNECAMPTPQQFQQILENIANKYIPNTP

26.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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