smf-3

NRAMP-like transporter smf-3

560 amino acids

Probable divalent metal ion transporter which regulates the uptake of several heavy metals such as Mn(2+), Al(3+) and iron (PubMed:19924247, PubMed:23106139, PubMed:19785996, PubMed:22194696). Plays a role in modulating Al(3+)-induced dopamine (DA) neuron degeneration through the intracellular sequestration of Al(3+) (PubMed:23106139).

Belongs to the NRAMP family.

63.186 kDa

MEGEMKCPIEEIREKPEMRKAQQTYEVQVEVEDTPDTTFSWRKLWAFTGPGFLMSIAYLDPGNIESDLQAGAISYFKLIWVLLVAHIMGLLLQRLAARLGVVSGKHMAEIAFSYYPKIPRLVLWMLVESAIVGSDMQEVIGTAISFYLLSNGVIPLWAGVLITICDTFTFLFLEKYGVRKFEAFFCFLITCMAITFGYEFGVSAPDAGKMFSGMFVPWCNGCDNNMVMQGVAIIGAVIMPHNFYLHSALVKSRRVDRRRAEKVTEANKYFFIESAFALFVSFIINTLVISVFAQGMYGKTNQDIRDTCYNNTHNGMPDFYKVEFPANNDAAQSDIYHAGIFLGCTFGIFALYVWAVGILAAGQSSTMTGTYAGQFAMEGFIQIKLPQWKRILITRSLAILPTLAVVIFSGGIDNISSLNDFLNCLQLIQLPFALIPVLTFVSDRNIMHEYKLASVSKVVSIVISLIILFINFYFLYSWIGSTFGYNAVSIPITIFCAIFYIIFIAYLTYYCLVAMEFISPIQTKWLAEPIYHDFDAPWLEDSENPSTKNTISDDELSMRY