Probable divalent metal ion transporter which regulates the uptake of several heavy metals such as Mn(2+), Al(3+) and iron (PubMed:19924247, PubMed:23106139, PubMed:19785996, PubMed:22194696). Plays a role in modulating Al(3+)-induced dopamine (DA) neuron degeneration through the intracellular sequestration of Al(3+) (PubMed:23106139).

Belongs to the NRAMP family.

560 amino acids

MEGEMKCPIEEIREKPEMRKAQQTYEVQVEVEDTPDTTFSWRKLWAFTGPGFLMSIAYLDPGNIESDLQAGAISYFKLIWVLLVAHIMGLLLQRLAARLGVVSGKHMAEIAFSYYPKIPRLVLWMLVESAIVGSDMQEVIGTAISFYLLSNGVIPLWAGVLITICDTFTFLFLEKYGVRKFEAFFCFLITCMAITFGYEFGVSAPDAGKMFSGMFVPWCNGCDNNMVMQGVAIIGAVIMPHNFYLHSALVKSRRVDRRRAEKVTEANKYFFIESAFALFVSFIINTLVISVFAQGMYGKTNQDIRDTCYNNTHNGMPDFYKVEFPANNDAAQSDIYHAGIFLGCTFGIFALYVWAVGILAAGQSSTMTGTYAGQFAMEGFIQIKLPQWKRILITRSLAILPTLAVVIFSGGIDNISSLNDFLNCLQLIQLPFALIPVLTFVSDRNIMHEYKLASVSKVVSIVISLIILFINFYFLYSWIGSTFGYNAVSIPITIFCAIFYIIFIAYLTYYCLVAMEFISPIQTKWLAEPIYHDFDAPWLEDSENPSTKNTISDDELSMRY

63.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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