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sit1

Gene
SIT1
Protein
Siderophore iron transporter 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
628 amino acids
Function
Involved in the transport of siderophore ferrioxamine B and so has a role in iron homeostasis.
Similarity
Belongs to the major facilitator superfamily.
Mass
70.562 kDa
Sequence
MDPGIANHTLPEEFEEVVVPEMLEKEVGAKVDVKPTLTTSSPAPSYIELIDPGVHNIEIYAEMYNRPIYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYSQHSLLSTVNCIKTVIAAVGQIFFARLSDIFGRFSIMIVSIIFYSMGTIIESQAVNITRFAVGGCFYQLGLTGIILILEVIASDFSNLNWRLLALFIPALPFIINTWISGNVTSAIDANWKWGIGMWAFILPLACIPLGICMLHMRYLARKHAKDRLKPEFEALNKLKWKSFCIDIAFWKLDIIGMLLITVFFGCVLVPFTLAGGLKEEWKTAHIIVPEVIGWVVVLPLYMLWEIKYSRHPLTPWDLIQDRGIFFALLIAFFINFNWYMQGDYMYTVLVVAVHESIKSATRITSLYSFVSVIVGTILGFILIKVRRTKPFIIFGISCWIVSFGLLVHYRGDSGAHSGIIGSLCLLGFGAGSFTYVTQASIQASAKTHARMAVVTSLYLATYNIGSAFGSSVSGAVWTNILPKEISKRISDPTLAAQAYGSPFTFITTYTWGTPERIALVMSYRYVQKILCIIGLVFCFPLLGCAFMLRNHKLTDSIALEGNDHLESKNTFEIEEKEESFLKNKFFTHFTSSKDRKD

Gene
sit1
Protein
Siderophore iron transporter 1
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
577 amino acids
Function
Major facilitator transporter involved in ferrichrome (FC) and ferrioxamine B (FOB) uptake (PubMed:26929401).
Similarity
Belongs to the major facilitator superfamily.
Mass
62.903 kDa
Sequence
MAMHDPHEKNGPDAVESRVQTDFPVERFGGNGSPGVRRIEVISSQFNLVHRIIFFFGVFLIAYVYGLDGTIRYTYQPLATAEYQSHSLLATVNVLRSVIAAAAQPTAAKIADVFGRVELILLSIVFYTVGTIVEASANHLYEFCAGAVLYQIGYTSVILLVEVLIADVTSTRSRLLFSYIPALPFLINTWISGNVTSAVLKVTSWQWGIGMFAIIYPVCTIPLLAVLFVGHLKARRANPQAYKFSLLDQGVGQFFIDLFWYLDVVGILLLIAILALILVPFTIAGGAVTQWKTAKVIAPLVIGVLCVPAFIVWERWCPHPMVPFKLLKDRAIWGALGIAVMLNTAWTLQGDYLYTVLIVSFDESVMSATRITSLYSFVSVITGTILGAIVIYVRRLKPFIVAGTLVFMAAFGILIRFRGGADGTNHAGIIGGQILLGFAGGLFPYPAQASVQVASKHKYLAVITGIYLATYNVGSALGNTISGAIWTQVLPGELENRLGNATLAAEVYANPFAFTQVNPVGTPDRDAVILAYKHAQRLLCITGICLTVPLIAFSLCIRNPRLTKEQTLKEAEEIDDK

Gene
SIT1
Protein
Signaling threshold-regulating transmembrane adapter 1
Organism
Homo sapiens
Length
196 amino acids
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
Mass
21.126 kDa
Sequence
MNQADPRLRAVCLWTLTSAAMSRGDNCTDLLALGIPSITQAWGLWVLLGAVTLLFLISLAAHLSQWTRGRSRSHPGQGRSGESVEEVPLYGNLHYLQTGRLSQDPEPDQQDPTLGGPARAAEEVMCYTSLQLRPPQGRIPGPGTPVKYSEVVLDSEPKSQASGPEPELYASVCAQTRRARASFPDQAYANSQPAAS

Gene
Sit1
Protein
Signaling threshold-regulating transmembrane adapter 1
Organism
Mus musculus
Length
180 amino acids
Function
Negatively regulates T-cell antigen receptor (TCR)-mediated signaling. Involved in positive selection of T-cells.
Mass
19.578 kDa
Sequence
MSRDYNCTTDDQLAWGIPSISHAWGLWALLGVVTVLLLISLAALLSQWTRGRRRNQEGQGPLSGRSAEEVPLYGNLHYLQTGRLSQEPRSEEQDPPSSGGLARGAEEAMCYTSLQLRPAQGRIPSSGNPIKYCEVVLDSEPKPQAPGPEPELYASVCAQTRRGRASFPDQAYANSQPAPS

Gene
Sit1
Protein
Signaling threshold-regulating transmembrane adapter 1
Organism
Rattus norvegicus
Length
178 amino acids
Function
Negatively regulates T-cell antigen receptor (TCR)-mediated signaling. Involved in positive selection of T-cells.
Mass
19.368 kDa
Sequence
MSRENNCTTADLAWGIPSITQAWGLWALFGVVTMLLLISLAALLSQWTRGRRRTQEEQGPPSGRSVEEVPLYGNLHYLQTGRLSEESRSEEQDPSSGGLARGAEEATCYTSLQLRPAQGRIPSSGTPIKYCEVVLDSEPKPQASGPEPELYASVCAQTRRARASFPDQAYANSQPAPS