Protein
RNA polymerase sigma factor SigF
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Function
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase (PubMed:14977982).
Similarity
Belongs to the sigma-70 factor family.
Sequence
MTARAAGGSASRANEYADVPEMFRELVGLPAGSPEFQRHRDKIVQRCLPLADHIARRFEGRGEPRDDLIQVARVGLVNAAVRFDVKTGSDFVSFAVPTIMGEVRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAPSASELAAELGMDRAEVIEGLLAGSSYHTLSIDSGGGSDDDARAITDTLGDVDAGLDQIENREVLRPLLEALPERERTVLVLRFFDSMTQTQIAERVGISQMHVSRLLAKSLARLRDQLE