SETDB2

Histone-lysine N-methyltransferase SETDB2

719 amino acids

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

Belongs to the class V-like SAM-binding methyltransferase superfamily.

81.894 kDa

MGEKNGDAKTFWMELEDDGKVDFIFEQVQNVLQSLKQKIKDGSATNKEYIQAMILVNEATIINSSTSIKGASQKEVNAQSSDPMPVTQKEQENKSNAFPSTSCENSFPEDCTFLTTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDENTMKNIFSKKRKLEVACSDCEVEVLPLGLETHPRTAKTEKCPPKFSNNPKELTVETKYDNISRIQYHSVIRDPESKTAIFQHNGKKMEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFEDNLLIESDVIDITKYREETPPRSRCNQATTLDNQNIKKAIEVQIQKPQEGRSTACQRQQVFCDEELLSETKNTSSDSLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL

Setdb2

Histone-lysine N-methyltransferase SETDB2

713 amino acids

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

80.636 kDa

MEEKNGDAKTFWMELQDDGKVDLMFEKTQNVLHSLKQKIKDGSATNGDYVQAMNLVNEATLSNTQTLEKGMFITYSNPEVNTHRSNHTPVTQSEQENKSSAVPSASCDNSCPKGCTIPSPGKKVFLPVKNKADNLVKKEAPLHISFHRHICSRTCLMETPLSLKGENPLQLPIRCHFQRRHAKTNSHSSALHVNYKTPCGRNLRNMEEVFHYLLETECNFLFTDNFSFNTYVQLTRNHPKQNEVVSDVDISNGVESVSIPFCNEIDNSKLPRFKYRNTVWPRIYHLNFSNMFSDSCDCSEGCIDIKKCACLQLTAKNAKACPLSSDGECAGYKYKRLQRLIPTGIYECNLLCKCNKQMCQNRVIQHGVRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLRRATPEKTNIGENGREQQHIVKNSFSKKRKLEVVCSDCDAHCDSPKAEDCPPKLSGDLKEPAVEMNHRNISRTQHHSVIRRTKSKTTVFHYSEKNMGFVCSDSAAPEDKNGFKPAQEHVNSEARRAHEDLSSNPAGDSEDTQLTESDVIDITASREDSAPAYRCKHATIVDRKDTKQVLEVPGKKSQEEEPAASQSQQALCDEELPSERTKIPSASLMQLSKESLFLLDASKEGNVGRFLNHSCCPNLWVQNVFVETHDRNFPLVAFFTNRYVKARTELTWDYGYEAGATPAKEILCQCGFNKCRKKLI

setdb2

Histone-lysine N-methyltransferase SETDB2

703 amino acids

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

78.698 kDa

MEQSANARQSTLRSRTQELNTLSVLSKDVSLEDAKKYWKDRQADGKVDWIFEKVLNKLKILWQKIKDGSATNLEYVRAVILVNEAGNLEEDLEEDLKEDTDTIHIDIHKENEVQENTDCSPERKEDTCLNLNTDCGTDVSGSEPECNSTVSPPAAERVYFGNHSCGPSCLSGINSFLFTKGNPLQLPISCDFQRCHLKINSPDDLSHILYKAPCGRSLRDYDEVHSYLTETGCHFLAVDNFSFNNHVRLDSNSSFNQGIVQDCDISNDVESVPVAFSNEIDNTRPSNFIYRKTSWPPGYSLNNFTDIFVKCCNCTDGCLDILTCSCLQLTAQAFTKCMESSLGIGPLGYKHKRLQEPIPTGLYECNVSCKCDRMLCQNRVVQHGLKLRLQVFKTNTKGWGVRCLDDVDKGTFVCIYAGRILIRTADCTVKSTPDDSVACGNEDHEDSTSTCALILSKRKRKTSHSDSEVTVMHTNPYSMRSHGLSVHRLSNTFSPRQARSGEREFSLQPLRRPKTKTSMLQKRRRQLIEEGACTVQNSSEEEGPTPPQSPEQKSSAGTKIQRNENSDETASGYVSEESSSSVISGGHPLEKPISKFKSKLNKTTVYLSTSPEQTCEENLHFLDASKEGNVGRFLNHSCCPNLFVQQVFVDTHQKCFPWVAFFTNSVVKAGTELTWDYSYDIGTAADQEIQCLCGQKTCKNKVV

setdb2

Histone-lysine N-methyltransferase SETDB2

697 amino acids

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

78.015 kDa

MERSTNARHSTLSSWTRESNTLSVLSKDVSLEDAKEYWKDCQADGKVDWIFEKLLNKLKILWQKIKDGSATNLEYVRAVILVNEAEQLEEDTETLHTDIQKENKVQENTDCAPERKEDSCADLNSDCETDVSGSECEHEDHSTVSPPATGAVCFGKHLCGPSCLSDINPSLLKKENPLNLPVSCDFQRWRVKTNGSEYPPHILYKAPCGRSLRDSDEVHSYLTETGCHFLGVDNFSFSTQVQLESHLSIKQEIVQDCDISNDVESVPVSLSNEIDDTRPTNFIYRKTSWPPGYSINNFTDIFVKCCSCTDGCLDISTCSCLQLTAQAFEKFTDSSLGIGPLGYKHKRLQEPVPTGLYECNLSCKCDRTLCQNRVVQHGLQLRLQVFKTDTKGWGVRCLDDVDNGTFVCIYAGRILIRTADSSVKTTLEDSVACGNEAKEDNGSTSTLMLSKRKRKPSHSDSEVTVMHLTPYSMRSLGLSVHRQSNTLSLTHLRSGGREISLEPFRRPKTKTSMLQKRRRQLIEEGACTVHNSSEEEGPTPPQSPKQKFNAGRKIHRNENSDETASGYVSEESSSSVISGGHPSEKPTCRTKSKLNKMTPHLSTSPEQTCEEDLHFLDASKEGNVGRFLNHSCCPNLFVQHVFVDTHQKSFPWVAFFTNSVVKAGTELTWDYNYVIGTAPDQEIQCLCGQQTCKHKIV

setdb2

Histone-lysine N-methyltransferase SETDB2

551 amino acids

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. During early development, required to specify the left-right axis by repressing expression of FGF8, leading to negatively regulate the dorsal organizer formation.

Belongs to the class V-like SAM-binding methyltransferase superfamily.

62.424 kDa

METEADTAKTFWSEVDVDGVFDELMEVLRRLRHTLRHNTATDREYVQAMRIVQESKLIRTETEDVLLDEDILTVTVSEPQCSPESLQNGIEPEDPQHSTARLYSDVGVVCSHMSSSRPDPAAPLVFQPHVCSSACVPHLPAHTHHLLGHNPLRAPLLCHFQRVCDDAGVVYKAPCGRSLSCMQEVLHFLLQTQSVCVLQTDRFSFSTQVCVERQVCAAPLLERDLSRGLEPVPVALVNTVDGARPREFRYRRERWPHGCFLSAEPLYSVCCDCTDGCTDAHSCACVRRTAGAAYTHQRLTHTLRTGLFECGPWCGCERSRCENRVVQKGLRVRLQVFRTPEHMWAVRCRDDLDAGTFICIYAGVVLRLQQSSECPAERSGEPAVSDDEVQLVEEWRIPEETHTHTHTLDSSPPLHVPVIQRPAEHSLAQRRDQQQFSISSETEDNRCEQALRKKPRLMESNGLQDSRTHTLTHTHDGVYYLDASREGNVARFFTHSDDPNLFIQNVFTDTHDPQFPLIAFFTCRPVKAGTELTWSCTNTEQQKTEEKHCSV