Description
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity).
Family
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Species
Xenopus tropicalis
Sequence
MERSTNARHSTLSSWTRESNTLSVLSKDVSLEDAKEYWKDCQADGKVDWIFEKLLNKLKILWQKIKDGSATNLEYVRAVILVNEAEQLEEDTETLHTDIQKENKVQENTDCAPERKEDSCADLNSDCETDVSGSECEHEDHSTVSPPATGAVCFGKHLCGPSCLSDINPSLLKKENPLNLPVSCDFQRWRVKTNGSEYPPHILYKAPCGRSLRDSDEVHSYLTETGCHFLGVDNFSFSTQVQLESHLSIKQEIVQDCDISNDVESVPVSLSNEIDDTRPTNFIYRKTSWPPGYSINNFTDIFVKCCSCTDGCLDISTCSCLQLTAQAFEKFTDSSLGIGPLGYKHKRLQEPVPTGLYECNLSCKCDRTLCQNRVVQHGLQLRLQVFKTDTKGWGVRCLDDVDNGTFVCIYAGRILIRTADSSVKTTLEDSVACGNEAKEDNGSTSTLMLSKRKRKPSHSDSEVTVMHLTPYSMRSLGLSVHRQSNTLSLTHLRSGGREISLEPFRRPKTKTSMLQKRRRQLIEEGACTVHNSSEEEGPTPPQSPKQKFNAGRKIHRNENSDETASGYVSEESSSSVISGGHPSEKPTCRTKSKLNKMTPHLSTSPEQTCEEDLHFLDASKEGNVGRFLNHSCCPNLFVQHVFVDTHQKSFPWVAFFTNSVVKAGTELTWDYNYVIGTAPDQEIQCLCGQQTCKHKIV
Simulated SDS-PAGE

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service