set-26

Gene

set-26

Protein

Histone-lysine N-methyltransferase set-26

Organism

Caenorhabditis elegans

Length

1645 amino acids

Function

Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro (PubMed:24685137). Involved in transcriptional regulation (PubMed:29714684). Plays a role in the negative regulation of lifespan and in heat resistance (PubMed:29714684). Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion (PubMed:22212395, PubMed:29714684). Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline (PubMed:29714684). Together with spr-5, required for transgenerational fertility (PubMed:24685137).

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Mass

181.666 kDa

Sequence

MADGEHTLPADEELFEQPPLQQQQPEIAEPIVMAQEPIQGVSEDPQASEATHEAPDNYPVDHQMENQEFYQEPQIPEPQQIPQIPVFQPAAYNPPNYVAPQQRANNFGEPAAAADSRPLTEEEQLAAERPTEDTVWIDSDDDTDVEEAILRANFWLPYSDHNYDPPDPADRIILPTEGPFPCIAGLDEDCNIVKQWMPEDAVGPGSPGTQYRRNQQTGGGLPSTSVAPQQQQLPVRHNIQNRPMVAAQPFSIGGNQVEYGGIGGMDSRMQQRGVVRDGPQYRVMNDFGNGLPMRGQLPPRNSPAANAINRVREQQQQMYHQAGARGSLQQRVPAPAAPTPGSYQHIVNAVPVGGANPMRRVPPQARPGMIGGAANNNRARPIHVTRPMDTQEFEHPVAPAAAAPPRRVVDVAPHRMTPEQRQELQQMNRQRAAPQFPAAAAQRSAEKIVIQQRPGASSSRAPRPSMAQEDLLRSPTRRLSERVPQEHQTPVLEPRRFQVKVTDTYSTPIPKASDQLPAQLTEEDPPEESAAAAAPEDVPDAAPEDPPKGILKPTPPHRMTQEEKNAHFARLTTDKEKPTSSASILPQDAAPPHVPPPPPPPLVLRPHHQDETLAMVQSVFESKPRQPDTPKDKEAISKIADLLRFSADEFTGQSGSSAAARQRTVSGSAARAQTYQMHHQQQQQHHHQMPMDQRKRHSSGRYDALMGAMPLQQQPPPPPPSQFQHTDSIAHRPRGRPKGTRHPSVAVQPQRSGGARTLPPRAQTVAMSARNGANAKNSDSESEGIDEAAEESWTMRCHCGMDHGDGDTIECEGCKTWQHMACMGLTLKSNTSKYKCEMCLPRRLPVSKAEAAREQERILNRLRAAAKKQKRKSEPVEQKQKSQPSTSRKSAPMALQQQPAEPRVAQLNDYSKQASALLFGMEQTAGADTLLAESRLHKKARRMFVEEAVEALVTTDLVQIRQVILEVNGHVSMSNEVKRQPGGGNCIFMYDGLMKGTAGEDMGDGQELVCIDTKRKGNDTKFTRRSCVPNCVLKHVLGSNATLGIMIVATKDITRNTEVTLPFDADWRESEVELECAEHMKELQACPFESERRRFAAERHRAMDHKKREAEEARRADEERRRLEEEVRRERAAKTKQMDEAEKARLEAEKAAEKEKKAKEREEAKERKKMEVEASAAAAPESSNSITAREERRIQQAEEMFRRQEEEGKRKEARRRSKSVTPGVLEAAGTAAREDAPEASIPAPAPSPPASRRSVSRTTQPSTSSFATPTEPPAKNKRMRSVVPPKSEPASSAKRVRATTVATPKDTTASNDSRKRKSSATGKTPVAKRSKNVVPTSFGLALIEKELREQARDSTVLEMILPDYIMKEKRSGLLAGQSPDFSEVRAQIEEENRMKERFTKREAKKKAVEKAKEKEKKEHRKEPKKANEPGPAPKSEKAVEKAVEKVEKKPKSPQKPPAKPTAQKPPLKKTEEVDGIEREASESSSKESSVAPEEKKNPKKITFAEYNSRRSQKREAGECSTPPAVTRRGFIPSTEGEDLVNVELSAIPLDDHPSSSNTAPTTTIAPSVGGAPKPTSVVVKSPSTRSRTRGAASESVDDAPAEHSMSLQDRVFSMFGSTVDAPAPPPPPPASAETNSRRSRSTRWN

Protein

Histone-lysine N-methyltransferase set-26: set-26