Protein expression services for set-26 | Histone-lysine N-methyltransferase set-26
Description
Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro (PubMed:24685137). Involved in transcriptional regulation (PubMed:29714684). Plays a role in the negative regulation of lifespan and in heat resistance (PubMed:29714684). Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion (PubMed:22212395, PubMed:29714684). Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline (PubMed:29714684). Together with spr-5, required for transgenerational fertility (PubMed:24685137).
Family
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Species
Caenorhabditis elegans
Length
1645 amino acids
Sequence
MADGEHTLPADEELFEQPPLQQQQPEIAEPIVMAQEPIQGVSEDPQASEATHEAPDNYPVDHQMENQEFYQEPQIPEPQQIPQIPVFQPAAYNPPNYVAPQQRANNFGEPAAAADSRPLTEEEQLAAERPTEDTVWIDSDDDTDVEEAILRANFWLPYSDHNYDPPDPADRIILPTEGPFPCIAGLDEDCNIVKQWMPEDAVGPGSPGTQYRRNQQTGGGLPSTSVAPQQQQLPVRHNIQNRPMVAAQPFSIGGNQVEYGGIGGMDSRMQQRGVVRDGPQYRVMNDFGNGLPMRGQLPPRNSPAANAINRVREQQQQMYHQAGARGSLQQRVPAPAAPTPGSYQHIVNAVPVGGANPMRRVPPQARPGMIGGAANNNRARPIHVTRPMDTQEFEHPVAPAAAAPPRRVVDVAPHRMTPEQRQELQQMNRQRAAPQFPAAAAQRSAEKIVIQQRPGASSSRAPRPSMAQEDLLRSPTRRLSERVPQEHQTPVLEPRRFQVKVTDTYSTPIPKASDQLPAQLTEEDPPEESAAAAAPEDVPDAAPEDPPKGILKPTPPHRMTQEEKNAHFARLTTDKEKPTSSASILPQDAAPPHVPPPPPPPLVLRPHHQDETLAMVQSVFESKPRQPDTPKDKEAISKIADLLRFSADEFTGQSGSSAAARQRTVSGSAARAQTYQMHHQQQQQHHHQMPMDQRKRHSSGRYDALMGAMPLQQQPPPPPPSQFQHTDSIAHRPRGRPKGTRHPSVAVQPQRSGGARTLPPRAQTVAMSARNGANAKNSDSESEGIDEAAEESWTMRCHCGMDHGDGDTIECEGCKTWQHMACMGLTLKSNTSKYKCEMCLPRRLPVSKAEAAREQERILNRLRAAAKKQKRKSEPVEQKQKSQPSTSRKSAPMALQQQPAEPRVAQLNDYSKQASALLFGMEQTAGADTLLAESRLHKKARRMFVEEAVEALVTTDLVQIRQVILEVNGHVSMSNEVKRQPGGGNCIFMYDGLMKGTAGEDMGDGQELVCIDTKRKGNDTKFTRRSCVPNCVLKHVLGSNATLGIMIVATKDITRNTEVTLPFDADWRESEVELECAEHMKELQACPFESERRRFAAERHRAMDHKKREAEEARRADEERRRLEEEVRRERAAKTKQMDEAEKARLEAEKAAEKEKKAKEREEAKERKKMEVEASAAAAPESSNSITAREERRIQQAEEMFRRQEEEGKRKEARRRSKSVTPGVLEAAGTAAREDAPEASIPAPAPSPPASRRSVSRTTQPSTSSFATPTEPPAKNKRMRSVVPPKSEPASSAKRVRATTVATPKDTTASNDSRKRKSSATGKTPVAKRSKNVVPTSFGLALIEKELREQARDSTVLEMILPDYIMKEKRSGLLAGQSPDFSEVRAQIEEENRMKERFTKREAKKKAVEKAKEKEKKEHRKEPKKANEPGPAPKSEKAVEKAVEKVEKKPKSPQKPPAKPTAQKPPLKKTEEVDGIEREASESSSKESSVAPEEKKNPKKITFAEYNSRRSQKREAGECSTPPAVTRRGFIPSTEGEDLVNVELSAIPLDDHPSSSNTAPTTTIAPSVGGAPKPTSVVVKSPSTRSRTRGAASESVDDAPAEHSMSLQDRVFSMFGSTVDAPAPPPPPPASAETNSRRSRSTRWN
Mass
181.7 kDa
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service
Make set-26 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)
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