psenB

Gene

psenB

Protein

Presenilin-B

Organism

Dictyostelium discoideum

Length

473 amino acids

Function

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity (By similarity).

Similarity

Belongs to the peptidase A22A family.

Mass

52.559 kDa

Sequence

MSSDNNNDPFDLNEDGHDYFNRVSTTTSPNRQSINSSPKQSSPKSTNNNDDKNNIILDLNDNNNDNNNTNNYNDEDIDVDNKNKFENKDNTYNSNGGSNNKNKNKKKDNKSNNSSDNEEADENTSLISDSEPLLNKKEKDDEQIEIENLDGEDYDDEVSLQDFSSMIVSIIIPVSITMMAVVFFVKYLNNQTLYASTLSYTIAGGSSGGGSGADSITGNSFVDSLIVAGIVLGMIIVTTVAFVLLYKYRCLKILYGWLFLSVGMMLGSFGTTFFQAMLSAANLPLDYITFAFLIFNFTVCGIIGVFWYAHQYVNQLYLVIISVLMAISLTRLPQWTIFTLLVIVAIYDLFAVLCPRGPLKVLVELSQERNENIPALVYETGKGSDSNLKLGLGDFIFYSLLISRAALVHMSCVFSTFIAILTGLFLTLLCLAIFKKALPALPISIFLGILFYYLSNNFLTPFIEALTLSQIFV

Protein

Presenilin-B: psenB