Protein
pH-response regulator protein palA/prr-1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease palB/cpr-8 via snf7/vps-3 to its substrate pacc-1 (By similarity).
Similarity
Belongs to the palA/RIM20 family.
Sequence
MTTTHVLSLPFRKSTQLSLSRAIQQYISAKYDQHPDMFRHDLDTIDALRRDAINVREAHPSGIRKLQMYAAQLVWIGGKFPIDVGADFTWYPALGYHTEHPLVQNNLKYELMNVLYNLAALYSQLAVASNRNSTEGLKTAASWFSHSAGVLTHIKTQVLPELRMPSPPDDMDETTLESLIQLFLAEAQECYWQKAVMDGYKDASIAKLAARVSDLYNEAGEAAMRSEAISSAWIHHMSAKHHHFAAAAQFRAASDCLERKKYGEEIARLRDAVACVNEGLKETRGGYLSKAVVEDLQGLKRRLEEDLKRAEIDNDRVYLHIVPPKTELKRLDRANMAVARVPPQVAKPYEFLGDPSAEFGPALFTKLVPFAVHVAVSIYEERRDRLVNNSIISELESMTSQLHEILSSLNLPGSLQALEKPLGLPGTLVQHADEIRQADALYRLQQGLTDIDKLCSSDLAIFEEGRSLLLAEEEEDSRLRLKYGTERWNRPQSRQDPSPNGGTKLWRQAQDIEGYFGSSTASDQVVREKFNAVRDTLTILAGSDRSIMDFIPNSRRTDIPESLKPALGRLRSAYNDVQRLESRRRKRVESLRARSRADDIKPDILVEAARLERAYPTTAIATAHFEDFFEKRLDRLYESELEAVERDKQEQEKIVQEVKRANKEFEAQKRQVDRAGGGNREREEALQKLDAAYYKYKEIVSNVEVGRKFYNDLSQIVEQWRGLVRGWVSERRRDARSLEEEINMPPLSSLNMHQSSFSYQQQQHHQQPPPPPPQIPFPEPIQPHQPIVEQAHIQSWADNVPQQQPKPVAPGAWAPNMGIKFGSPVAQGQQHQQEQGQPGPVNATWDPSQGIRFG