Protein
Putative RNA exonuclease pqe-1
Organism
Caenorhabditis elegans
Function
Putative RNA exonuclease which protects neurons from the toxic effects of expanded poly-Q disease proteins (PubMed:12486229). It is unknown whether this is via participation in the pathogenic mechanism underlying poly-Q-induced neurodegeneration or if it is by acting as a genetic modifier of the age of onset or progression of neurodegeneration (PubMed:12486229). Regulates gene expression in neurons (PubMed:22870397).
Similarity
Belongs to the REXO1/REXO3 family.
Sequence
MFNGGYGSGNSFNLQNYAPIDPMTGIPGFGPSQNAQQQQQQASAPGTSSGGPSQAVSGASSGASMKTEPVARQVSTAQMKRDLEQAAVYVPTPIPEGSTQPQQRQQQQSQPQARQMSTQQAANLRKNAAAAGTPPKQAMQGASREQGNAHQPTAGQIPQSSNQPAQQTHNVPRMPQPLQQVPHPSPVRGSHPAAQQVQNAPQRIPQHVPMPQGVAPHQVIQQVRAPNIGASQMVQQAPSRGHTGAAPASRMAQQPVPLHQGVAPHQAAPQTIQQTPARGRPANAQLAQNAQQRNPQQVPMPQGVAPHHIPPQALGPHGAAPQMTQQAPARGPSGAAQHAQNAHRMTHQQVPLQAPVQGPHRGAPQMAQQPGPHGAAQHPSSGTVAPMHITSLPGNHPLNRTHLLFNRQVVPALDIRNLIAQHRLMVDDFVRAQICYRLPENHQDYWPPGGHPIPMQQQQMRQGAGLPNMAMPPPPLMRHPGPHQNPIHAMQSMQVQPPLSPDQMNMQMFQQRALMMQQQAMQMQMQNPPPVHQQPPPQQPPQQQRQKQQRSQPAPARVPPQVPSQVPVTGGVAADEPPPPCSYSPVAQSSESKIEPVDVKPRVAPVPPQVPVTPTKPVITNNKKKRIDVVTLDEDAPRRVQVKQEIPEVSSTSDATKSDAAPTARGAVRIKQEVESDVAPNTILISAKKFERMKAEAEDKEDMKKKIAALQEALFNIQEERRVEKEIAAFATTNQAVPQNQPASSVQIAQVSTSESDAPGTSEAAATETMTSPKTKNNVIVETEGEQEEDEDEIPIKKSKKRRAKIVSNDEEEEPVRHPKRRSDEKREKRHVSYAESDDDMPVVKKKRRNQSPEDPEYSAASPSEDEDDDIGSFVVSDNEDDDADSFVVGDDEPIEYEEEDEDDMIERRSSRKRRSDSRSKKSATPTDRRRSRDTPTGSRSMRSTSPNDRRKSRETPPGNRSMRRTSPSDGRKSRDTPTASSSMSSSTLSYCKKSKETPMSYEEIEQQKKAKRQRNCKTREENRERKRLAQLEELESSETTGVRRTLRSTQDNSDPLDASLATTIEEFRKTKKKDAKSSENRAKEKQKPMNKRPTSSASVDSNDDGVHIPAKRMAHASSVPGPSRSKPPMIGAVKNRPNHTEMLDKRNKESEEKRRKDRDELERLRNKKHTTEEEKIKMARLQNALKVVGKAAGLKATVKKELTGSPAKKQKPAPAVPKILDFSVGRTFTAIRQTAIKLVFDTFLERDSPNAAREAQEFELSIAKQYTDGQKYRINIGHKVAALRKENTSGILEVNKNAVSHDKILAGGPKDNCTVARGRKTHVDHRQLSIEKLHPLLLQFKLTTSELETNAYPMRRDGSTKAVSIADTVYTQNKKMFLDDYDMSRNCSRCNKEFKLSPNGTMIRSTGICRYHNRGVAINGKRDTFRKRYSCCNEEFNVALGCKFSDVHVTDQLFKKELSTFVSTPVPVPNDQRSTRVYALDCEMVYTIAGPALARLTMVDMQRNRVLDVFVKPPTDVLDPNTEFSGLTMEQINSAPDTLKTCHQKLFKYVNADTILIGHSLESDLKAMRVVHKNVIDTAILFRSTRDTKVALKVLSAKLLHKNIQGDNEDAIGHDSMEDALTCVDLIFYGLRNPESIAIREANTNC