PFS2

Polyadenylation factor subunit 2

713 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

76.581 kDa

MTAPTVPADQHGHPLPGPADPAANDTWRPSRYREPLHPDNEEVLEQAAYQAAVTRSSGDDRKRKIKPRRTVDYQGGVQKWRMLNKLKGVHEFRPAIHPNPSDIVNFLPPVALRSNPSTSICDYWVHTSINKERSPTRVVRWTPDARRLLTGNDKGQFTLWNGASFNYESITQVHDDSIRSFTYSHNGQALVSADKGGTIKYFTPHLTNIHGFQGHREACHDVSWSPNDERFVTCGDDGLVKIWSYREAKEERSLSGHGWDVRCVDWHPTKGLIVSGSKDMLVKFWDPRTGKDLSTLHSSKSTINTCRWSPDGHLVATAGQDSVIRLFDIRTFRELEVLKGHEKEVNCIEWHPIHHSLLVSGDALGTINYFSLLSPTPSTPITTLSAAHEDAVFSLSFHPLGHILCSGSKDFTARFWCRARPPGGQEFDKWHLTEEGAAQKELERITKREWGTNALPANAAGGGGGGGGGDKQQVALPGLSNLVAAVNSVKTGPTTTGGGPPGLPGLGAPNVHAGTPPSRVSTPSSMGPPGAGAQGQAQGGQFPRGRAALPSQNDMLRHNHGPRGGFADRDRNGGGDRGGMDRDRDSRGGRQDPRGNQMYGRGPGGPPPGPPPGQGGYNYPPAPPNYPPYPPSSYPPPPNNQPGYPPAPNYAMPPGPGAPPQSYPYNRPPQGPPQNNNPGGQGNYGASASGGYGQYGGGGGGGGGGGYGRDGRR

PFS2

Polyadenylation factor subunit 2

712 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

76.53 kDa

MTAPTVPADQHGHPLPGPADPAANDTWRPSRYREPLHPDNEEVLEQAAYQAAVTRSSGDDRKRKIKPRRTVDYQGGVQKWRMLNKLKGVHEFRPAIHPNPSDIVNFLPPVALRSNPSTSICDYWVHTSINKERSPTRVVRWTPDARRLLTGNDKGQFTLWNGASFNYESITQVHDDSIRSFTYSHNGQALVSADKGGTIKYFTPHLTNIHGFQGHREACHDVSWSPNDERFVTCGDDGLVKIWSYREAKEERSLSGHGWDVRCVDWHPTKGLIVSGSKDMLVKFWDPRTGKDLSTLHSSKSTINTCRWSPDGHLVATAGQDSVIRLFDIRTFRELEVLKGHEKEVNCIEWHPIHHSLLVSGDALGTINYFSLLSPTPSTPITTLSAAHEDAVFSLSFHPLGHILCSGSKDFTARFWCRARPPGGQEFDKWHLTEEGAAQKELERITKREWGTNAPPANAAGGGGGGGGDKQQVALPGLSNLVAAVNSVKTGPTTTGGGPSGLPGLGAPNVHAGTPPSRVSTPSSMGPPGPGAQGQAQGGQFPRGRSALPSQNDMLRHNHGSRGGFADRDRNGGGDRGGMDRDRDSRGGRQDPRGNQMYGRGPGGPPPGPPPGQGGYNYPPAPPNYPPYPPSSYPPPPNNQPGYPPAPNYAMPPGPGAPPQSYPYNRPPQGPPQNNNPGGQGNYGASASGGYGQYGGGGGGGGGGGYGRDGRR

PFS2

Polyadenylation factor subunit 2

612 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

66.452 kDa

MAYEPRGDHGGGGGGQGQDGAFVKVRGRRPVTDYGATITHWQHDRAPGYKGGYTGEAERPSASYIVDMLPPAARVTKAADSIPIKHLHSSLNKIKHPINVVRWTPEGRRLLTASTSGEFTLWNGTGFNFETIMQAHDSAIRALEYSHSDDWLISADHDGAVKYWQPNFNNVQSINAHTDPIRDLAFSPSDSKFVTASDDSTLKIFDFALGQMESKLEGHGWDAKSVDWHPTKGLLVSGSKDHLVKLWDPRTSRCLTTLHGHKSTITKVLFEKVRGACLATSARDQTARVFDLRMMRDICLLKGHEKDISTLTWHPVHPNLLSTGGMDGSLFHYLLDSPNPPPGQSFTVAPYDSPDPTTVPAQSVWPTHKVPYAHDYAIWSLDWHPLGHILASGSNDRITRFWSRARPGDAEVFQDRYHIGEAAAEAQGTWDRRGGRRQRQEEEQQEMEDEMDALVDQDAPKAGVPGLPGIPGLPLGGLPGLGSAVPPPPIPGVGAGGPPPPLPFPLPGLNGSLPPPPLPGLDPNNPPDPAQLLELMKKAGVPLPPPGALPPGLLPPGGIPPPPGGFGMPIPPPPMSALEAEKAENVRRRAPLPSQEDSLRHEQRQGKYTRAR

pfs2

Polyadenylation factor subunit 2

610 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

67.397 kDa

MAFYDDSGADSQPFGRPQKPYEGGIVGPRRPRLVTDYGSSLVQWMRTRRPRYKGGHRMETERPSASYIVDMLPPLARIHSPVDTIPVRHLHQSIGKSKKPITVVRWTPEGRRLLTGGHTGEFMLWNGTAFNFETVMDAHYDQLQAGVTSLAWSHSHDWLISGGQKGDIKYWRPNFNNVETIDDAHHDAVRDLAWSPSDTKFLSASDDTTLKIFDFTSRTADTVLTGHNWDVKSCDWHPTKGLLVSGSKDHQVKFWDPRTARCLTTLHSHKNTVTATRFSRVNQNLLATSSRDQTARVFDLRMMRDICILRGHEKPVSSLTWHPIHSSLISTGSEDGSLYHYLLDEPNVPSGQIPTIAPYDSPDPANTPAQVIYPAHRVQYAHSATIWSLDWHPLGHILASGSKDNFTRFWSRARPGETSYMKDRFHIGEEAAEAQGTWSRGFGRRQMREEEEQELQDEAESLVDQRKPTGSVLPGIQIAPPGGTPHNDGLGSQLLPGIGAPQPPPAPSAGIPSSMPQMDPNRLAALLSTQGAPQPNSIPPNTGFPGFPMLPALSGTPPANVDLAELQKQLMSQGIPLPQNFAPQHFSPLPGTGGLPGLQGSNTPDNPYGR

pfs2

Polyadenylation factor subunit 2

567 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

62.593 kDa

MAYYDDGGNDSQPFGRAQGGIQGPRRPRLVTDYGSSMVQWMRNRRPKYQGGHRMETERPSASYMVDMLPPLARIHSPVDSIPVRHLHQSIGKSKKPITVVRWTPEGRRLLTGGHTGEFMLWNGTAFNFETVMDKGDVKYWRPNFNNVETIDDAHHDAVRDLAWSPSDTKFLSASDDTTLKIYDFTARTCDTVLTGHNWDVKSCDWHPTKGLLVSGSKDHQVKFWDPRTARCLTTLHSHKNTVTATKFSRVNNNLLATSSRDQTARVFDLRMMRDICILRGHEKPISTLTWHPVHCSLISTGSEDGSLYHYLLDEPNLPAGQIPTVAPYDSPDPANTPAQVIYPAHRIQYAHAATIWTLDWHPLGHILASGSKDNFTRFWSRARPGETSYLKDRFHIGEEAAEAQGTWSRNFGRRQMREEEEQELQDEADSLVDQRKTPGTGLPGIQSASQPDGLGSSLLPGIGAAQPPPPPGLSTSMAPPGNAFPPNPVFPAFPFAPPFSGAPPASGAQPMNSPNVNLAELQKQLAAQGITLPPGFPHHFTPVSTPLAGGGLPGLQGGYQPDNNYGR

PFS2

Polyadenylation factor subunit 2

543 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

60.961 kDa

MYRSHNNNNNYHSRNDGSNGRINKPRDPKSQDKYVAYQQNIEQQLASQEKKQAYRRITDHGNNMGRWYIEKSLGLTNRSQQAIGTIRPESSYLIDLLPSLAYSSSFNLNRRNNKNNLAVLDLQTKFVHLSSNKVKHTINTVKWTPEGRRLLVASHSGEFTLWNGMTFNFETIMQAHESPILTMKYSNHDEWLLSGDQNGTVKYWQPNFNNVNNISAHANGVRDIAFSPNDSKFLTCGDDSAIKIWNFNNGKEERTLSGHHWEVKSADWHPNLGLIVSGSKDNLVKLWDPRSANCVSTLHGFKHTVNKTRFQPNGTARLLASVSRDRSCRIFDLRTMKDMLVIRDSETDLSCVAWHPIHASMVTTAAYNGSISNFLLDSYIPDSNESVPKRSNNNSNLSTNTNNTIDAVQKIPYAHEKAIHAVEYHPLGHLLCTAGSDKTARFWSRARPNDPMAWKDAVYTDCKAGAWYYSVNNNVNAVMEDPNAVKNEDDEIANNDDPLSNSGRRRGVGASASGGATGSVPGLRSRNETPNNGSYAIPGLRGF

PFS2

Polyadenylation factor subunit 2

532 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

58.961 kDa

MSSDSGPLHRRTIPISVHIFSGFFYAPFYAPQLTQFIVTITMYSTYQRPAGYQPRQQPQGEEDRRPAHRRTVDHGSAFGKWHLDRLSGRTIQPANMRSEQSYIVDLLPPSAYTNINGSLRSTNPHITSVAATPAKFIQVALNKVRHPVYSATWTPDGRRLLTGSMSGEFTLWNGMTFNFESIMQAHESGVRSLKYSHSGEWLLSGDHEGNVKFWQPSLNCVNVIDKAHRESIRELAFAPSDHKFVTGSDDGLLKIWDFHESSNAESVLKGHGWDVKSVDWHSELGLIVSGSKDNLIKLWDPRSAKNVNTFHGFKNTVMKTTFQPTGTKRLLAAGCRDRTCRILDLRMLNSGSSEAGPTAGTDMPTRGDRSMAVLRGHDSDVFSLTWHPTHANVVTSGTKTGSIYTFNVDTTPAGGAYGPDSGILPVNTIPSAHDYCVSTLDYHPEGHVLCSGGLDRMTRFWARPRPGDPTSFRDKYYEPKEEGVSVKTLPGVNNATSRAGMARVEHVSTQHFNTAQPEVTDDEPVSIPGFAR

pfs2

Polyadenylation factor subunit 2

510 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

56.077 kDa

MLPPLARIHSPADTIPVRHLHQSIGKSKKPITVVRWTPEGRRLLTGGHTGEFMLWNGTAFNFETVMDVRGQKGDIKYWRPNFNNVETIDDAHHDAVRDLAWSPSDTKFLSASDDTTLKIFDFTARTADTVLTGHNWDVKSCDWHPTKGLLVSGSKDHQVKFWDPRTARCLTTLHSHKNTVTTTRFSRVNSNLLATSSRDQTARVFDLRMMRDICILRGHEKPISSLTWHPIHSSLISTGSEDGSLYHYLLDEPNLPSGQVPTIAPYDSPDPANTPAQVIYPAHRIQYAHSATIWSLDWHPLGHILASGSKDNFTRFWSRARPGETSYMKDRFHIGEEAAEAQGTWSRGFGRRQMREEEEQEAQDEAESLVDQKNTTAQSLPGIQIAPPGLGSLQTGSGSLLPGIGAPQPAPQAGMSASMPQMDPGRLAAILSQQNPSQPQNFPSATGIPGFPMPPAMSGTPPLNIDLAELQKQLLSQGISPQNFASLAASLGSAGLPGLQSSTPDNTYRR

pfs2

Polyadenylation factor subunit 2

509 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.

57.654 kDa

MERAENARIIQKPMTRRTVDYGSGLSKYIVNRHLRSNRYHIHVPRPNPNQIINLYPPYEYKYNNTSSLCTKYIHTSANKARHVINVVRWTPDGRRLLTGSSTGEFTLWNGLTFNFELINQSHDYAVRCAEWSTDGRWLISGDGGGMVKYFEPNLNNVKIVQAHEMEVRDVAFSPNDSKFVTASDDGSLKVWNFHMSTEELKLTGHGWDVKTVDWHPSKGLLASGSKDNLVKFWDPRTGTCIATLHGHKNTIMQASFQKNFGSNYLATVSRDSTCRVFDLRAMKDVRVLRGHEKDVNCVTWHPLYPNLLTTGGSDGSVNHYSLDEPPLLSQQKYHEKHPNVTLSASSYLLYPTAEIPFAHDLGIWSMQYHPLGHLLCTGSNDKTTRFWSRSRPDDKESTMDRHHLGEEQSEAMLSQRKAAIEEDDNYEPDENPLTETLANAHNPQFSGVLNLPGLGTMPSFPSPYQHGQPQIPGMLHASLSNSYAEPSTQNSFIPGLTSKSQDGYPQNYR

PFS2

Polyadenylation factor subunit 2

504 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

56.696 kDa

MFNNNSNNGNSNGNRGYNNNNRNNERSQGYNQNIEQQLASQEKKTAYRRTVDHGNNMGRWYINRSLGIDDQPIGKIRPESSYLIDLLPSPAYASNSVRENKNNMSIMDIQTKFVHLSSNKAKHSINTVKWTPEGRRLLVASHSGEFTVWNGMTFNFETIMQAHDSAILSLKYSHNDEWLLSGDQSGVIKYWQTNFNNVNIINGHSDGIRDIAFSPNDSKFLTCSDDSTMKIWNFNNGQEERSLVGHHWDVKSADWHPNLGLIVSGSKDNLIKLWDPRASSCVSTLHGFKHTITKTKFQPTGTKRLLASVSRDKSCRIFDLRTMKDILVIRDHETDLSCVEWHPVHPSMITTAAYDGSMNHYIMDSYISDNNIKNDSNNNSTSPIEASHKIPYAHEKAIHALEYHPLGHLLCSAGADRSARFWSRARPNDPMSFQDALYTNDKVGAWYYGVNNNINAVIEPSTASVNKDDPSSAQAINLPGLNNLPNGNESTTNGWGNIPGLRGH

PFS2

Polyadenylation factor subunit 2

465 amino acids

Integral and essential component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May bridge the CPF and CFIA complexes.

53.143 kDa

MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGAAPPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI

PFS2

Polyadenylation factor subunit 2

455 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

51.57 kDa

MDQSAAVEGVPQKKYLTLRRSVDVSSSYNRLYYLKKHGLSLPPIEPETSFTANIMPPDAYKRNDRIVNLPTKFTHLSSNKVKHVIPAIQWSPEGRRLIVATFSGEFSLWNGSSFTFETIMQAHDTSVTTMKYSHAGDWMISGDADGTIKIWQPNFNMVKELDRIHTEGIRDVAFSNNDSKFVTCSDDNILKIWNFSNGQQERVLSGHHWDVRSCDWHPELGLIVSGSKDNLVKLWDPRSGQCVSTLLKFKHTVLKTRFQPTKGNLLAAISKDKSCRVFDLRASMNELMCVRDEVDFMELEWSTINESMFTVGCYDGSLKHFDLGQDTEKPIHIIPFAHEKCISAIAYNPVGHILATAAKDRTIRFWTRARPVDPNAFDDPTYNNKKMTGWFFGINNDINAVREKSEYGAAPPPASTAFPQQTQYNNNISRVPEIKEPTPTTDKEQRTSILPGLSI

PFS2

Polyadenylation factor subunit 2

452 amino acids

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

50.882 kDa

MDPNTEGTTTKKYTSQRRTIDISASYDRLYFLKKHGQENSSYIEAETSYNAHILPPDAYGFHGHAINTATKFTHLSSNKVKHVIPALTWTPEGRRLVVATYNGEFSLWSGSSFNFESIMQAHDSAVTVMTYSHTGDWMVSGSADGELKIWQPNFNMVKVMDQAHMECVREISFSPTDQKFVSCSDDNVLKIWNFSNGQQERVLSGHHWDVKSCDWHPKMGLIVSGSKDNLIKFWDPRSGSCVSTMLGFKHTIISTKFQPKQGNLLSVISKDKTCKVYDIRQQAKELFSVRDDVDYMTLQWHPIDETVFTVGCYDGSIKHFDLSQENQPNKPTHNIPYAHEKCVTSLAYSPIGHIMASASKDRTIRFWTRSRAVDPNAFDDPTYNNEKVNAWYFGINNNINAVRNKTEHGVALPPSEDSNNNENGDGSRSVEPERPSVSTLPGLGSGLPGLSF