Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

612 amino acids

MAYEPRGDHGGGGGGQGQDGAFVKVRGRRPVTDYGATITHWQHDRAPGYKGGYTGEAERPSASYIVDMLPPAARVTKAADSIPIKHLHSSLNKIKHPINVVRWTPEGRRLLTASTSGEFTLWNGTGFNFETIMQAHDSAIRALEYSHSDDWLISADHDGAVKYWQPNFNNVQSINAHTDPIRDLAFSPSDSKFVTASDDSTLKIFDFALGQMESKLEGHGWDAKSVDWHPTKGLLVSGSKDHLVKLWDPRTSRCLTTLHGHKSTITKVLFEKVRGACLATSARDQTARVFDLRMMRDICLLKGHEKDISTLTWHPVHPNLLSTGGMDGSLFHYLLDSPNPPPGQSFTVAPYDSPDPTTVPAQSVWPTHKVPYAHDYAIWSLDWHPLGHILASGSNDRITRFWSRARPGDAEVFQDRYHIGEAAAEAQGTWDRRGGRRQRQEEEQQEMEDEMDALVDQDAPKAGVPGLPGIPGLPLGGLPGLGSAVPPPPIPGVGAGGPPPPLPFPLPGLNGSLPPPPLPGLDPNNPPDPAQLLELMKKAGVPLPPPGALPPGLLPPGGIPPPPGGFGMPIPPPPMSALEAEKAENVRRRAPLPSQEDSLRHEQRQGKYTRAR

66.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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