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octT

Gene
octT
Protein
Diglucosylglycerate octanoyltransferase
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
252 amino acids
Function
Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can also be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis.
Similarity
Belongs to the OctT acyltransferase family.
Mass
27.762 kDa
Sequence
MSSETSSESTGHRPVLLVFADSLSYFGPTGGLPADDPRIWPNIVGEQLGWDVELIGRIGWTCRDVWWAATQDPRSWAALPRAGAVVFATSGMDSLPSPLPTALREMIRYVRPPWLRRWVRDGYGWVQPRLSPIARSALPPHVTVEYLEMTRNAIDFNRPGIPVVASLPSVHIAETYGRAHHGREPTVRAITAWAEEHHVPLVDLKAAVADEVFGGRGNPDGIHWSFEAHRAVAELMLKGLAEAGVTQRDSAT

Gene
octT
Protein
Diglucosylglycerate octanoyltransferase
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
247 amino acids
Function
Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can also be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis.
Similarity
Belongs to the OctT acyltransferase family.
Mass
27.225 kDa
Sequence
MSSRRGRRPALLVFADSLAYYGPTGGLPADDPRIWPNIVASQLDWDLELIGRIGWTCRDVWWAATQDPRAWAALPRAGAVIFATGGMDSLPSVLPTALRELIRYVRPSWLRRWVRDGYAWVQPRLSPVARAALPPHLTAEYLEKTRGAIDFNRPGIPIIASLPSVHIAETYGKAHHGRAGTVAAITEWAQHHDIPLVDLKAAVAEQILSGYGNRDGIHWNFEAHQAVAELMLKALAEAGVPNEKSRG

Gene
octT
Protein
Diglucosylglycerate octanoyltransferase
Organism
Mycobacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 / 3849)
Length
240 amino acids
Function
Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). Can also use hexanoyl-CoA as acyl donor in vitro. DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis.
Similarity
Belongs to the OctT acyltransferase family.
Mass
26.579 kDa
Sequence
MSGRRPTLLVFCDSLSYYGPRGGLPADDPRIWPNIVASQLDWDVELIGRVGWTSRDVWWAATQDPRAWAALPRAGAVIFATGGMDSLPSPLPTALRELIRYIRPPWLRRRVRDLYGWLQPRLSPVSRNALPPHLTAEYLEMTRGAIDFNRPGIPVVAALPSVHIADSYGRAHHGREATARAITEWARQHGVVLVDLKAAVADQVLNGRGNPDGIHWNFEAHQAVAELMLKALAEAGVPCR