Protein
Diglucosylglycerate octanoyltransferase
Organism
Mycobacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 / 3849)
Function
Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). Can also use hexanoyl-CoA as acyl donor in vitro. DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis.
Similarity
Belongs to the OctT acyltransferase family.
Sequence
MSGRRPTLLVFCDSLSYYGPRGGLPADDPRIWPNIVASQLDWDVELIGRVGWTSRDVWWAATQDPRAWAALPRAGAVIFATGGMDSLPSPLPTALRELIRYIRPPWLRRRVRDLYGWLQPRLSPVSRNALPPHLTAEYLEMTRGAIDFNRPGIPVVAALPSVHIADSYGRAHHGREATARAITEWARQHGVVLVDLKAAVADQVLNGRGNPDGIHWNFEAHQAVAELMLKALAEAGVPCR