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oaz1b

Gene
oaz1b
Protein
Ornithine decarboxylase antizyme 2
Organism
Danio rerio
Length
218 amino acids
Function
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity.
Similarity
Belongs to the ODC antizyme family.
Mass
24.245 kDa
Sequence
MVKSNLQRILNSHCFAREKEGKKQCESSIMEALSSSITDRMASPTVCCSSTTGPGPLWCSDAPHPPLKIPGGRGNGARDHPSTTQTLYSDRKLTVTEEPAGPGRPQILHFQSRPAAARLIQWEAVLRGDGLFVEIPCEPFPDGSKESFISLLEFAEEHLKVVSVFVCFYKNREDRVKLVRTFSFLGFEMVKPGHALVPARPDVLFMAYNFDRDSSDED