Protein
Ornithine decarboxylase antizyme 2
Function
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity.
Similarity
Belongs to the ODC antizyme family.
Sequence
MVKSNLQRILNSHCFAREKEGKKQCESSIMEALSSSITDRMASPTVCCSSTTGPGPLWCSDAPHPPLKIPGGRGNGARDHPSTTQTLYSDRKLTVTEEPAGPGRPQILHFQSRPAAARLIQWEAVLRGDGLFVEIPCEPFPDGSKESFISLLEFAEEHLKVVSVFVCFYKNREDRVKLVRTFSFLGFEMVKPGHALVPARPDVLFMAYNFDRDSSDED