Description
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity.
Family
Belongs to the ODC antizyme family.
Sequence
MVKSNLQRILNSHCFAREKEGKKQCESSIMEALSSSITDRMASPTVCCSSTTGPGPLWCSDAPHPPLKIPGGRGNGARDHPSTTQTLYSDRKLTVTEEPAGPGRPQILHFQSRPAAARLIQWEAVLRGDGLFVEIPCEPFPDGSKESFISLLEFAEEHLKVVSVFVCFYKNREDRVKLVRTFSFLGFEMVKPGHALVPARPDVLFMAYNFDRDSSDED
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service