Protein
Nucleoporin nup186
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
Similarity
Belongs to the NUP186/NUP192/NUP205 family.
Sequence
MDVWESQHFSALLYLLQCIESNPSNPNVSSRLLIQCLESYSKDFLKFLALDPANANSRKKLESGEVELGGVINKVNEQFIQLSLTLSTQLNLDEIQCASLLQRGIEASQNLDRTPVQAALYFFFLAREQLLECLESLTRVVGLKDLESDISTALKSYLQSLCENGNNLVKTCIDTIPILDNKVSEILKSEAGGQILGVSEVVDFQEFIRLSHEAHVAELETISVILYQLAKVDLFQNSHFESLLVMLRKYDSPNKNAVLILPTLYAFIDKVLEVEYLPDQKVQLRSNSVEILQKIHQAIIQSPSQDWRSSQFKNILGIWWVTRLNATCKQIEKVPSFIDYETTIKNAANEIIQNGVFSDMITLLVYPFRQSETEGMEWAFAFKSRSRITVNWSLIRPFIASIIFSELRSFAQAFVSYMPDILKTLRLLEEDRYLTNTTYPTSIPGEQIEEYFPFEEFYYLLSSIYTYNVSWISDFWDDIESDMYGFLTWSMGSQIPGIITAFTLLLASLCKNTTSASKIYELFSEPIPEVGHLESLMITSPSWSYIFNVFRYYISHLKPVQTVVTSSGLARVHTDPSEIDTDSALILQAYILLFSSVVRQDAQIASTFCENQDLNPIATLFELLECRLPDSVRICIVRALESLAHLSTGSFNNALWTALDNWFVSSVLFDVDGGLAPMSIPAISKRSLTKPVTSCGPLLNNIRRLTVNLEMKISFVNLLTSLTRNKSELNVNLTFPENLGASYRTPGVQPYVDYVVETFVASSTQWRLMRDVGSIRLQYACLQYMLAVLDGLNIDLLLYSRILSSKVRDNLQNNNLHVYLTRHPAISLLEALYTESVYSGLFDLVEYGFDQLEDVSVPKTIVITVSASLCILRNVLSLQRVLFKNVVPYIAELGISKYILDLTISRRAYKEVFMTRISSIVHLALLVGSRHKCFLRSAIEILSYLVDAEGFMNKRNPDENKLLCSIIRTANESKRIIFGFIRTFESQFLTLLSTNDESSLILKLLLNNLKQSGGVYSLALLILGFDISSTNVITLRDQPGYVGSRVSLMNSLLDFIEGRTIVNGIWETPVIMVQALEIVAFLCSCPLTSEVTLSVIRARPGLLVKMVDGEPILTQQVIQNLGGFSSEEVSMVSRCIRSRTQIMNMLATEIHYAASVGQNKYLNEYVASLIRTNEKTHSTELSQKESGFKILEFMDILRIDPQSITFELPNIPGFNLNMFITRFDRGHSDFQFDTERVLKIYRLFFEAEMTSLGGSAEEKYSWLEQQNSKLKELAQRLNTFNAHVVLLQDIHGCLTAWARLTGLLVDDCNEVISDVHFDDFIWEVLRLVLPGVTVHNLGTQGTVSVTSSVIETILPHALRRIGALKPEELGKSTYFMEGIHDVIVGLLKGIQCQQSDESIRENLYGSLLSILTVFQKHTSANGGDKVDPVFKDAFQKLITPNLLTSQFFDVLTKDALYTNGSCWELSVIILNFLHHVSPDISTHLYKYYLRRNFVSSFIDAFSRAFSELLSSNKDVLEVLSGLEAGQCLLITFAQNKLTVHSVLTFDYIKLMVQMLLQLCKQGGIQYLKPPVQRLMIQLLQIFILVLMRVTLKEISNKDKLLLQSIFLLSRKLQDSVQTGADQALSPEMNTVKKYVETISRLLDLYRD