Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.

Belongs to the NUP186/NUP192/NUP205 family.

1647 amino acids

MDVWESQHFSALLYLLQCIESNPSNPNVSSRLLIQCLESYSKDFLKFLALDPANANSRKKLESGEVELGGVINKVNEQFIQLSLTLSTQLNLDEIQCASLLQRGIEASQNLDRTPVQAALYFFFLAREQLLECLESLTRVVGLKDLESDISTALKSYLQSLCENGNNLVKTCIDTIPILDNKVSEILKSEAGGQILGVSEVVDFQEFIRLSHEAHVAELETISVILYQLAKVDLFQNSHFESLLVMLRKYDSPNKNAVLILPTLYAFIDKVLEVEYLPDQKVQLRSNSVEILQKIHQAIIQSPSQDWRSSQFKNILGIWWVTRLNATCKQIEKVPSFIDYETTIKNAANEIIQNGVFSDMITLLVYPFRQSETEGMEWAFAFKSRSRITVNWSLIRPFIASIIFSELRSFAQAFVSYMPDILKTLRLLEEDRYLTNTTYPTSIPGEQIEEYFPFEEFYYLLSSIYTYNVSWISDFWDDIESDMYGFLTWSMGSQIPGIITAFTLLLASLCKNTTSASKIYELFSEPIPEVGHLESLMITSPSWSYIFNVFRYYISHLKPVQTVVTSSGLARVHTDPSEIDTDSALILQAYILLFSSVVRQDAQIASTFCENQDLNPIATLFELLECRLPDSVRICIVRALESLAHLSTGSFNNALWTALDNWFVSSVLFDVDGGLAPMSIPAISKRSLTKPVTSCGPLLNNIRRLTVNLEMKISFVNLLTSLTRNKSELNVNLTFPENLGASYRTPGVQPYVDYVVETFVASSTQWRLMRDVGSIRLQYACLQYMLAVLDGLNIDLLLYSRILSSKVRDNLQNNNLHVYLTRHPAISLLEALYTESVYSGLFDLVEYGFDQLEDVSVPKTIVITVSASLCILRNVLSLQRVLFKNVVPYIAELGISKYILDLTISRRAYKEVFMTRISSIVHLALLVGSRHKCFLRSAIEILSYLVDAEGFMNKRNPDENKLLCSIIRTANESKRIIFGFIRTFESQFLTLLSTNDESSLILKLLLNNLKQSGGVYSLALLILGFDISSTNVITLRDQPGYVGSRVSLMNSLLDFIEGRTIVNGIWETPVIMVQALEIVAFLCSCPLTSEVTLSVIRARPGLLVKMVDGEPILTQQVIQNLGGFSSEEVSMVSRCIRSRTQIMNMLATEIHYAASVGQNKYLNEYVASLIRTNEKTHSTELSQKESGFKILEFMDILRIDPQSITFELPNIPGFNLNMFITRFDRGHSDFQFDTERVLKIYRLFFEAEMTSLGGSAEEKYSWLEQQNSKLKELAQRLNTFNAHVVLLQDIHGCLTAWARLTGLLVDDCNEVISDVHFDDFIWEVLRLVLPGVTVHNLGTQGTVSVTSSVIETILPHALRRIGALKPEELGKSTYFMEGIHDVIVGLLKGIQCQQSDESIRENLYGSLLSILTVFQKHTSANGGDKVDPVFKDAFQKLITPNLLTSQFFDVLTKDALYTNGSCWELSVIILNFLHHVSPDISTHLYKYYLRRNFVSSFIDAFSRAFSELLSSNKDVLEVLSGLEAGQCLLITFAQNKLTVHSVLTFDYIKLMVQMLLQLCKQGGIQYLKPPVQRLMIQLLQIFILVLMRVTLKEISNKDKLLLQSIFLLSRKLQDSVQTGADQALSPEMNTVKKYVETISRLLDLYRD

186.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make nup186 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here