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notum1

Gene
notum1
Protein
Palmitoleoyl-protein carboxylesterase notum1
Organism
Xenopus laevis
Length
488 amino acids
Function
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Functions in the prospective ectoderm and is required for neural induction.
Similarity
Belongs to the pectinacetylesterase family. Notum subfamily.
Mass
54.784 kDa
Sequence
MAGALCVTLLLLLSTNTVSGRKTWRRRGQQIVPSGRERSEGGDESFPLDFTAVEGNMDNFMAQIKSLAQSLYPCSAQRLDDEMKLHILHNKSVTCNDGSSAGYYLKESKGSRRWLVFLEGGWYCISHENCDLRYDTMRRLMSSKAWPPAKTASGILSTQPEENPHWWNANMVFIPYCSSDVWSGASPKTEKSGYAFMGSLIIQEVVKELLGKGLDAAKVLLLAGSSAGGTGVLLNVDLVADLLEELGYPGIQVRGLSDSGWFLDNKQYRRTDCTDIITCAPTEAIQRGIRYWSSMVPERCKQQFKEGEEWNCFFGYKIYPTLRSPVFVVQWLFDEAQLTVDNVHLSGQPVQESQWLYIQNLGRELRNTLKDVGASFAPACLAHEVITRSHWTEIQVRGTSLPRALHCWDRRLQETNKNSKVPLKGCPFHLMDSCPWPQCNPTCPSIRDHFTGQEMSVVQFLMHLGFDVQKMASQQGMEPGKLLGVLSS