Description
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Functions in the prospective ectoderm and is required for neural induction.
Family
Belongs to the pectinacetylesterase family. Notum subfamily.
Sequence
MAGALCVTLLLLLSTNTVSGRKTWRRRGQQIVPSGRERSEGGDESFPLDFTAVEGNMDNFMAQIKSLAQSLYPCSAQRLDDEMKLHILHNKSVTCNDGSSAGYYLKESKGSRRWLVFLEGGWYCISHENCDLRYDTMRRLMSSKAWPPAKTASGILSTQPEENPHWWNANMVFIPYCSSDVWSGASPKTEKSGYAFMGSLIIQEVVKELLGKGLDAAKVLLLAGSSAGGTGVLLNVDLVADLLEELGYPGIQVRGLSDSGWFLDNKQYRRTDCTDIITCAPTEAIQRGIRYWSSMVPERCKQQFKEGEEWNCFFGYKIYPTLRSPVFVVQWLFDEAQLTVDNVHLSGQPVQESQWLYIQNLGRELRNTLKDVGASFAPACLAHEVITRSHWTEIQVRGTSLPRALHCWDRRLQETNKNSKVPLKGCPFHLMDSCPWPQCNPTCPSIRDHFTGQEMSVVQFLMHLGFDVQKMASQQGMEPGKLLGVLSS
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service