NMT1

Glycylpeptide N-tetradecanoyltransferase

706 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Belongs to the NMT family.

77.562 kDa

MSGIAGTSQDTSVAASASSSSTRPAAASSSIAPPSPSLTTAPVKEQEQDDDDDQENDDEEEEEEGTAAITGADGLTAKQRKKKKSKAAAKLRKKLGLGGSPTDASEGKLLASGSSREGKISDEVVSQVQRAVQAEHGSVAANAVTKANLAKVMAMMNLERDAMLKSQDSKQKAQKAIADHKFWKTQPVMKPTDAPVVKSDQEGSIEASVPPEQVRQEPYPLPADFEWVMIDVDNEGELKEVYDLLSANYVEDDDATFRFDYSPEFLHWVLKHPGYQKTWHIGVRVASTKKLVAFISGIPHELRVREKSYQSTEINFLCVHKKLRSKRLAPVLIKEVTRQCHLTGVFHAIYTVGSVLPTPVSCSRYYHRTINAKKLAEIGFSAIPHNMSMEAHVKRFELPAKTNLPGLREMERRDVAQVGKLMRRYMRRFDMAPRFSDHEVEHILLSGRGEACQGGRGRKGQVTWTYVVENSEGRITDMFAFYSLPSSILDSDKHQSLNAAYLFYYATDVVFQGDCDCDSDSSGVCDAETGRASTSQPSSERAVALAAGKAAWQCNSLTNLTSCELADEARVAAWDSEPAHIKTALKTRLNLLINTLLIIARDHDFDVVNCVTVMDNALFLQQQKFGPGDGFLRFYLFNWRTKPVAGGMGARPGEAELDPVQAYARSMAKRAAHTDDDDVKRLAEQLIRNAAINPAEVGSGNGIVMV

NMT1

Glycylpeptide N-tetradecanoyltransferase

564 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Belongs to the NMT family.

63.944 kDa

MSEESKPVEPVVDETNAELKGKAIAQADPEADEHAESASEEEHEEEHAAEGSSDKKKKKKKKSKRSKVKEALTGSKSAPTDADFHKALDGLTPKEVKEFLALNPALAQEVSKASNSDNPSADQASDMLKKMSLQDIMTGLAAGGKNAKDMGSYKFWQTQPVPKFGEDNNLQEGPLRIQKVEEVDKEPSALIPGFEWVTMDLTKEEEIKEVYELLNKHYVEDDEAMFRFNYSPTILRWAMMPPGWKKEYHVGVRASQSGLLCAFISAIPVHLRVRDNVVTCSEVNFLAIHKKLRGKRLTPVLIKEITRRSNLDGIWQGLYTAGVVLPKPVSTCRYFHRAINWQKLYECGFSPLPANSKPQYQIRKYALPDDTAIKGLRPLQEKDIEAVMDLYHRYNKRFDMTPKMSREEALHWFLPKTGPGEQQAVWTYVVEDENNKITDFFSFFCIESTAIGNSKHNVIKVAYMFYYGTEVGLQDKFDKAALKKRLNDLVHDALIISKRYKFDVFNALTLMDNALFLEQQKFGAGDGQLHYYLFNYRVNPIAGGVDRKNQLDEENLSGIGLVMP

NMT1

Glycylpeptide N-tetradecanoyltransferase 1

497 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Belongs to the NMT family.

56.919 kDa

MGDESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMEKKDIPVVHQLLSRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNNLQYYLYNWKCPSMGAEKVGLVLQ

NMT1

Glycylpeptide N-tetradecanoyltransferase 1

496 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Belongs to the NMT family.

56.806 kDa

MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

Nmt1

Glycylpeptide N-tetradecanoyltransferase 1

496 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Required for normal embryogenesis.

Belongs to the NMT family.

56.888 kDa

MADESETAVKLPAPSLPLMMEGNGNGHEHCSDCENEEDNSHNRSGLSPANDTGAKKKKKKQKKKKEKGSDMESTQDQPVKMTSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMEKKDIPVVHQLLSRYLKQFHLTPVMNQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

NMT1

Glycylpeptide N-tetradecanoyltransferase 1

496 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Belongs to the NMT family.

56.746 kDa

MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGSTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRIHLEGVFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

Nmt1

Glycylpeptide N-tetradecanoyltransferase 1

496 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Belongs to the NMT family.

56.86 kDa

MADESETAVKLPAPSLPLMMEGNGNGHEHCSDCENEEDISHNRGGLSPANDTGAKKKKKKQKKKKEKGNDMDSTQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMEKKDIPVVHQLLSRYLKQFNLTPVMNQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

nmt1

Glycylpeptide N-tetradecanoyltransferase

492 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Belongs to the NMT family.

56.255 kDa

MSDSKDRKGKAPEGQSSEKKDGAVNITPQMAESLLENNPALRNETAGMDKDKAAEAMRKMNIAELLTGLSVSGKNQKDMASYKFWQTQPVPRFDETSTDTGGPIKIIDPEKVSKEPDALLEGFEWATLDLTNETELQELWDLLTYHYVEDDNAMFRFRYSQSFLHWALMSPGWKKEWHVGVRATKSRKLVASICGVPTEINVRNQKLKVVEINFLCIHKKLRSKRLTPVLIKEITRRCYLNGIYQAIYTAGVVLPTPVSSCRYYHRPLDWLKLYEVGFSPLPAGSTKARQITKNHLPSTTSTPGLRPMEPKDIDTVHDLLQRYLSRFALNQAFTREEVDHWLVHKPETVKEQVVWAYVVEDPETHKITDFFSFYNLESTVIQNPKHDNVRAAYLYYYATETAFTNNMKALKERLLMLMNDALILAKKAHFDVFNALTLHDNPLFLEQLKFGAGDGQLHFYLYNYRTAPVPGGVNEKNLPDEKRMGGVGIVML

NMT1

Phosphoethanolamine N-methyltransferase 1

491 amino acids

Catalyzes N-methylation of phosphoethanolamine, phosphomonomethylethanolamine and phosphodimethylethanolamine, the three methylation steps required to convert phosphoethanolamine to phosphocholine. Required for root system development and epidermal cell integrity through its role in choline and phospholipid metabolism.

Belongs to the class I-like SAM-binding methyltransferase superfamily. PEAMT family.

56.103 kDa

MAASYEEERDIQKNYWIEHSADLTVEAMMLDSRASDLDKEERPEVLSLLPPYEGKSVLELGAGIGRFTGELAQKAGELIALDFIDNVIKKNESINGHYKNVKFMCADVTSPDLKITDGSLDLIFSNWLLMYLSDKEVELLAERMVGWIKVGGYIFFRESCFHQSGDSKRKSNPTHYREPRFYSKVFQECQTRDAAGNSFELSMIGCKCIGAYVKNKKNQNQICWIWQKVSSENDRGFQRFLDNVQYKSSGILRYERVFGQGFVSTGGLETTKEFVEKMNLKPGQKVLDVGCGIGGGDFYMAEKFDVHVVGIDLSVNMISFALERAIGLSCSVEFEVADCTTKHYPDNSFDVIYSRDTILHIQDKPALFRTFFKWLKPGGKVLISDYCRSPKTPSAEFSEYIKQRGYDLHDVQAYGQMLKDAGFTDVIAEDRTDQFMQVLKRELDRVEKEKEKFISDFSKEDYDDIVGGWKSKLERCASDEQKWGLFIANKN

nmt1

Glycylpeptide N-tetradecanoyltransferase

466 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Belongs to the NMT family.

53.696 kDa

MDNENNKNTKNSQQDSSFSEGGIRELLDRLALRSLIEKEEAAAPPKTYEDFKFWKTQPVPKFDDECTQEGPIDPNTDINQVPREPYRLLKEFEWATIDVTNDNELSEVHELLTENYVEDATAMLRFAYISEFLRWALMPPGYVKEWHVGVRVKSSRKLVAFISAVPLSIRVRDKIIKKCAEVNFLCIHKKLRSKRLTPLLIKEVTRRCHLENVWQAVYTAGVLLPSPVSLSRYMHRSLNWKKLYDIGFAPFPLGSTEKKETAKYHLPPNTQTPGLRPMELKDVPAVQSLLSQYMERFELAHLFSEEEVRHWFLYTDKVSSGPVVWSYVVENPESKKITDFFSFYSLPSTVIGNPKYKDIQAAYLYYYASDSCPKDLSSESQLAFVERCKLIVNDALILAKKFHFDVFNAVTVLDNNLFLKDLKFGEGDGFLNYYIYNYNCPKIPGGIDASKSVDYSRPSGMGFVMI

NMT1

Glycylpeptide N-tetradecanoyltransferase

455 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Uncharged amino acids are preferred at position 2 while neutral residues are favored at positions 3 and 4. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6.

Belongs to the NMT family.

52.838 kDa

MSEEDKAKKLENLLKLLQLNNDDTSKFTQEQKKAMKDHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISDKPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFFNWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRYTHRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDIDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPDGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKATKALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGFLNFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML

NMT1

Glycylpeptide N-tetradecanoyltransferase

452 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Belongs to the NMT family.

52.754 kDa

MGDSGDAQKMQRLLEMLALNSGDMSKLTQQQRKAFEEYKFWKTQPVARFDEKVEEEGPINPPRRVEDVRDEPYPLLEEFEWRTMDITTGQDLEDVFVLLNENYIEDKDSTFRFNYTREFFNWALKPPGWRKEWHVGVRVRQSGRLVAFISAVPTTLEVRGREMKSVEINFLCIHKKLRSKRLAPILIKEITRRVNKCDIWHALYSAGIVLPSPISTCRYTHRPLNWSKLFDVGFTALPANATKTQMLAKYTLPKKPLVEGLRPMTDADVDGAFDLFNRYQKRFELIQTFDKSEFRHWFLGNEETPSVIYSYVVQNSEGKITDFVSFYSLPFTILKNPLHKELGIGYLFYYASDADFDYEDRYDPTATELLRKRLTQLINDVCILARDLKMDVFNALTSQDNALFLEDLKFGPGDGFLNFYLFNYRANPIRGGLTEDKKFDAKNRSNQGVVML

NMT1

Glycylpeptide N-tetradecanoyltransferase

451 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6. Basic residues are preferred at positions 7 and 8.

Belongs to the NMT family.

51.863 kDa

MSGDNTGNKSNSAPSKSIEELLKLLAMGQELSPAQQKEMKDYKFWKTQPVPSLSETVTEEGPIDKLKTPEDVPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYSHEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIHKKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGFSHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEFKHWMLGHDENSDSNVVKSYVVEDENGVITDYFSYYLLPFTVLDNAQHDELGIAYLFYYASDSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLFNYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL

NMT1

Glycylpeptide N-tetradecanoyltransferase

451 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Belongs to the NMT family.

52.659 kDa

MSEKKIEELLKLLSMNNGDMSKLTANQRKEMKEYKFWKTQPVTKFDEEVKEEGPIHEEKTPADIPDEPLPLLPDFEWCAIDVDDEKQLEDVFVLLNENYVEDRDASFRFNYTREFFNWALKSPGWTPDWHIGVRVKASKKLIAFISAIPVRLRVRAKVIDSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKRNIWHALYTAGVVLPAPVSTCRYAHRPLNWDKLYEVQFTDLPPNATKAEMVAKYTLPKATKTAGLRELRLEDVDQALALFNRYQSRFDIVQEFTKEEFIHWFINDKNVVEQDKRVVFSYVVESEGKVTDFFSFYSLPFTILNNSRYKDLGIGYLYYYASDADFKFEDRFDKEGTSLLKQRLSTLVQDACIIAAQNKMDVFNALSSQDNTLFLEDLKFGPGDGFLNFYLFNYRTFPITGGLTEDQHFDTEHRSNVGVVML

NMT1

Glycylpeptide N-tetradecanoyltransferase

451 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Belongs to the NMT family.

51.853 kDa

MSEEDKKDPPKSIEDLMKLLSMGESLTEPQQKQMKDYKFWKTQPVPSFDEKIDSEGPIDQTKTPDDIPDTPLPLLNEFEWSTVDLEKTDQLDEVYKLLYENYVEDQDATFRFKYSHEFFNWALKPPGWRTEWHAGVRVKETGKLVAFIAAIPITLKLNKSQKVIPSVEINFLCVHKKLRSKRLAPVMIKEITRRVNKYDIWQALYTGGVVLPSPVATCRYTHRPINWSKLYDVGFSHLPANQTKSGMLANYALPNTTKTQGLRSMKIEDLDQVYDLLHKFQEKFDIVQVFEKDELAHWLLGGKSTDTSSNVIKSYVVENSEGSLTDFFSYYLLPFTVLDNPSHDELGIAYLYYYASDTAFKNDDESAYKQRLSSLMSDALVTSKKYNVDVFNCLSSQDNPYFIKNCKFGSGDGFLNYYLFNYKTWPITGGIDPQTKELVEDKSSGVGVILL

NMT1

Glycylpeptide N-tetradecanoyltransferase

447 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Belongs to the NMT family.

52.323 kDa

MSEEDKSKKLEELLKLLKVHDGDLSKFTSQQRKDMNEYKFWKTQPVTKFDEVIKKEGPIDSSKRPEDIPDTPLPLLGDFEWCTVDVNDEKQLEDVYVLLNENYVEDKDSTFRFNYSRDFLNWGLKPPGWKEEWQVGVRVKETKRLVGFISAIPTNLQVRGNDVRSVEINFLCVHKKLRSKRLAPILIKEVTRRVNKYDIWQALHTGGVVLPSPVSSCRYAHRPLNWSKLYDVEFTALPANATKTQMIAKYTLPKTPISNIKLMEERHVDEAFELFNKYQQRFELRPNFDKEEFRHWILTREDVVYSYIIENDEGKVTDFVSFYSLPFTIINNPLYKDLGIGYMFYYASDADFGYDRFSAEGTERLRKRLNLLINDACILARNLKMDVFNALTSQDNALFLEDLKFGPGDGFLNFYLFNYRCFPITGGIKEDQTFDVEKRSNVGVVLL

NMT1

Glycylpeptide N-tetradecanoyltransferase

443 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Belongs to the NMT family.

51.097 kDa

MSADKFNEILKMFQQQMAMQDIPDREKAKKWEEYLFWKTQPVPKFDEDIDSEGPIEHKKLEDVRPTPYNLPAEYEWSDVDIENPEHIQEVYDLLYDNYVEDDDATFRFKYSASFLDWALKPPGWQKTWYPCVRVAATGKMVAFISAIPTSIQLRDNDLIKAVEINFLCVHKKLRSKRLAPVLIKEITRRVNQKDIWQALYTAGVVLPSPVSTCRYYHRPLNWTKLYEIGFSAIPPNQTAASMVARYTLPKEVPLKVRAMTKADVKAVHAILQNYLSAASEMSQHFSEEEVAHWFVDPISEDKNDDKIVYSYVVEEDGKVIDFFSFYKLDHTVLKEWATESNLRAAYGFYYATSSLSSAKARQDRVKELIGSAVILANNLGFEVYNELTLLDNPSHLDDLKFGCGDGYLNYYLFNYRAQPVHGGLDKQKQLEQLDGKGVGVIML

NMT1

Glycylpeptide N-tetradecanoyltransferase 1

434 amino acids

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Can also use decanoyl-CoA and lauroyl-CoA as substrates.

Belongs to the NMT family.

49.799 kDa

MADNNSPPGSVEQKADQIVEANPLVKDDTSLETIVRRFQDSMSEAKTHKFWETQPVGQFKDIGDTSLPEGPIEPATPLSEVKQEPYNLPSVYEWTTCDMNSDDMCSEVYNLLKNNYVEDDENMFRFNYSKEFLRWALRPPGYYQSWHIGVRAKTSKKLVAFISGVPARIRVRDEVVKMAEINFLCVHKKLRSKRLAPVMIKEVTRRVHLENIWQAAYTAGVILPTPITTCQYWHRSLNPKKLIDVGFSRLGARMTMSRTIKLYKLPDAPITPGFRKMEPRDVPAVTRLLRNYLSQFGVATDFDENDVEHWLLPREDVVDSYLVESPETHDVTDFCSFYTLPSTILGNPNYTTLKAAYSYYNVATQTSFLQLMNDALIVSKQKGFDVFNALDVMHNESFLKELKFGPGDGQLHYYLYNYRLKSALKPAELGLVLL

nmt1

4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase

346 amino acids

Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

Belongs to the NMT1/THI5 family.

38.966 kDa

MSTNKITFLTNWEATPYHLPIFLAQTRGYYEREGIEVAILEPTNPSDVTALIGSGKVDMGLKAMIHTLAAKARGYPVTSFGSLLNEPFTGLITLKGNGINDFKDIKGKRIGYVGEFGKIQLDDLCSKFGLSPSDYTAIRCGMNIAPAIINGEIDGGIGIECMQQVELERWCVSQGRPRSDVQMLRIDRLANLGCCCFCTILYIAHDEFIAKHPDKIKAFLRAIHSATLDMLKDPVQTYKEYIHFKREMGSELHREQFERCFAYFSHDISNVPRDWNKVTNYSKRLGIIPQDFEPNCTNGYLTWELDPDEKDPMGKQEAIAEIQDEIKQKGGVFSGNSLRYVEPANL

nmt1

4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase

342 amino acids

Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

Belongs to the NMT1/THI5 family.

38.198 kDa

MSTDKITFLTNWHATPYHAPLYLAQSKGYFKEEGLKVALLEPNDPSDVTEIIGSGKVDMGFKAMIHTLAAKARNFPVTSIGSLLDEPFTGVVYLKDSGITEDFRSLKGKKIGYVGEFGKIQIDELTKYYGMTADDYTAVRCGMNVTKAIIRGDIDAGIGLENVQMVELAEWLASQNRPRDDVQIVRIDQLAELGCCCFCSILYIANDAFLAANPEKVQKFMRAVKRATDYVLAEPAAAFEEYVDMKPIMGTPVNRKIFERSFAYFSRDLKNVSRDWAKVTNYGKRLGILDADFQPNYTNQYLSWTLDADSTDPLGDQKRMAELQKEVACEGGFKRLQVASSA