Protein
Kynurenine 3-monooxygenase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
Similarity
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Sequence
MEERKQKVVVVGAGPVGSLAALYAANRGHDVEIYELRGDLRDPSTTPLNFTRSINLALSERGLNAMRHANQPRLIDYVKGVTIPMRGRMIHGKRPDGKLYEEAQDYDIHGRSILAIDRGDLNKRLLDMLEEMPNVTFFFNHKLTGADFKRNKAWFENKDESTSNPRDRAREIEVDFDFMIGADGAHSAVRYHLMKFSRMDYQQEYIDTLWCEFQIAPSSSSAKSKFRISPNHLHIWPGKEFMFIAIPSNDGSFTCTLFAPAAIYEQLEEAGRTGDTSSSIPEFFDMHFPGVTSLIAPADLIAQFQTNPHLPLISIKCKPYHFSSSVVIVGDAAHAMVPFYGQGMNAGLEDVRILFDILDKHDRMTNDDSSLEASQRELALAEYSAVRVADAHAINDLALQNYIEMRSSVLSPVYRWRKALEEWLSVYVPSLGWQTKYSRVSFGNERYSEVVKKSERQGQVLLRSLVGGVGLPMLAGGLFLWFRYKGALGRAAYGVFYNCMGMVCRTIHGRRR