Protein
Sodium/hydrogen exchanger 1
Organism
Dictyostelium discoideum
Function
Regulation of intracellular pH homeostasis in response to cAMP, which is essential for chemotaxis. Necessary for F-actin localization and the kinetics of actin polymerization during chemotaxis and cell polarity but not for directional sensing.
Similarity
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Sequence
MKLNKSYILIVVLLLSLFYSSVSSTKTTLIKSNNHYNSDNSNNDNKNININNNNDGDGDDDDDNNKILITPENQNHLIHDIGIDSSSTEILFGSSSNSGSCGEKNNTKQNALANQREANTIIFIIMLILTGSVLIVYFIISLDIPFVPESVAVVTYGIILGIVFRFFYSDIVNHVVSFEPENFFLFILPTIIFETGYSLHKTDFFNNIGPILMFAVFGTIITFLVVGFGIYIVGYFGVSIALSLKDSFAFGSIISSTDPVCTLAIFQALNVDPMLYILVLGESILNDATSMMLYSVVEDTSTRDIIISCAMFTVVAIGSVILGVVMALLLSLILKWINIGKFPALETIFMVMFSYMSYVLAGALDISGVLAVFFFGITLNQYGAYSLSPYTKLTSGQLFRTAAFISETFLFLYFGLSLTAHEFKFDLGLFSWSILFTCLARAISVFPMCFLLNKFLKTKIPWVIQVAIWFAGLRGAFAFSLSLDYISEDEHMNAYIRTNTLLVVVFTIFVFGMGTYPLLRVLGIKTSQTDQSLDNISKPMSKQTKQKDRTKLYESFDDKYFKPWFRKRVPPLANEAIEIFEKMVIQSSHDHELDSNPLRFDDDEEDDDDEDLDFDSDLDLNININTDSIHQSDNNNNDNGNNNNNNNNIIINNNSQHHSNDGSNNKNNDTLPLI