Regulation of intracellular pH homeostasis in response to cAMP, which is essential for chemotaxis. Necessary for F-actin localization and the kinetics of actin polymerization during chemotaxis and cell polarity but not for directional sensing.

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

674 amino acids

MKLNKSYILIVVLLLSLFYSSVSSTKTTLIKSNNHYNSDNSNNDNKNININNNNDGDGDDDDDNNKILITPENQNHLIHDIGIDSSSTEILFGSSSNSGSCGEKNNTKQNALANQREANTIIFIIMLILTGSVLIVYFIISLDIPFVPESVAVVTYGIILGIVFRFFYSDIVNHVVSFEPENFFLFILPTIIFETGYSLHKTDFFNNIGPILMFAVFGTIITFLVVGFGIYIVGYFGVSIALSLKDSFAFGSIISSTDPVCTLAIFQALNVDPMLYILVLGESILNDATSMMLYSVVEDTSTRDIIISCAMFTVVAIGSVILGVVMALLLSLILKWINIGKFPALETIFMVMFSYMSYVLAGALDISGVLAVFFFGITLNQYGAYSLSPYTKLTSGQLFRTAAFISETFLFLYFGLSLTAHEFKFDLGLFSWSILFTCLARAISVFPMCFLLNKFLKTKIPWVIQVAIWFAGLRGAFAFSLSLDYISEDEHMNAYIRTNTLLVVVFTIFVFGMGTYPLLRVLGIKTSQTDQSLDNISKPMSKQTKQKDRTKLYESFDDKYFKPWFRKRVPPLANEAIEIFEKMVIQSSHDHELDSNPLRFDDDEEDDDDEDLDFDSDLDLNININTDSIHQSDNNNNDNGNNNNNNNNIIINNNSQHHSNDGSNNKNNDTLPLI

75.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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