About Products Protein Database Contact

mutY

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
378 amino acids
Function
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Similarity
Belongs to the Nth/MutY family.
Mass
43.505 kDa
Sequence
MLAKSSINAPFAKSVLAWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFERFIKTFPNITALANASQDEVLHLWTGLGYYARARNLHKAAQKVRDEFNGNFPTNFEQVWALSGVGRSTAGAILSSVLNQPYPILDGNVKRVLARYFAVEGWSGEKKVENRLWALTEQVTPTTRVADFNQAMMDIGAMVCMRTKPKCDLCPLNIDCLAYKNTNWEKFPAKKPKKAMPEKTTYFLILSKNGKVCLEQRENSGLWGGLFCFPQFEDKSSLLHFLAQEKVTHYQEWPSFRHTFSHFHLDIHPIYAEMESTLCVEQANLDWRKVMESTKEYQSNLSSAVKYWYDPQNPEPIGLAQPVKNLLIQFVRNHYGKNSIL

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Bacillus subtilis (strain 168)
Length
369 amino acids
Function
Base excision repair (BER) glycosylase that initiates repair of A:oxoG to C:G by removing the inappropriately paired adenine base from the DNA backbone, generating an abasic site product. 8-oxoguanine (oxoG) is a genotoxic DNA lesion resulting from oxidation of guanine; this residue is misread by replicative DNA polymerases, that insert adenine instead of cytosine opposite the oxidized damaged base. Shows a powerful dicrimination of A versus C, since it does not cleave cytosine in oxoG:C pairs. May also be able to remove adenine from A:G mispairs, although this activity may not be physiologically relevant.
Similarity
Belongs to the Nth/MutY family.
Mass
41.963 kDa
Sequence
MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWVSEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAVKEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSIWDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCSAFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLETQKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSKLKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Geobacillus stearothermophilus
Length
366 amino acids
Function
Base excision repair (BER) glycosylase that initiates repair of A:oxoG to C:G by removing the inappropriately paired adenine base from the DNA backbone, generating an abasic site product (PubMed:25995449) (PubMed:14961129). 8-oxoguanine (oxoG) is a genotoxic DNA lesion resulting from oxidation of guanine; this residue is misread by replicative DNA polymerases, that insert adenine instead of cytosine opposite the oxidized damaged base. Shows a powerful dicrimination of A versus C, since it does not cleave cytosine in oxoG:C pairs (PubMed:25995449). May also be able to remove adenine from A:G mispairs, although this activity may not be physiologically relevant (PubMed:14961129).
Similarity
Belongs to the Nth/MutY family.
Mass
41.835 kDa
Sequence
MTRETERFPAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSEVMLQQTRVETVIPYFEQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGGKVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVDGNVMRVLSRLFLVTDDIAKPSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLCPVQAYCQAFAEGVAEELPVKMKKTAVKQVPLAVAVLADDEGRVLIRKRDSTGLLANLWEFPSCETDGADGKEKLEQMVGEQYGLQVELTEPIVSFEHAFSHLVWQLTVFPGRLVHGGPVEEPYRLAPEDELKAYAFPVSHQRVWREYKEWASGVRRPD

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Length
351 amino acids
Function
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Similarity
Belongs to the Nth/MutY family.
Mass
41.563 kDa
Sequence
MTTLVFYQTILNWYHHFGRKTLPWQIKKNPYKTWISEIMLQQTQVKTVIPYYCKFIKRFPNIDTLSDSPLDSILNLWSGLGYYTRARNIYKTAKILKQKFNGIFPNSYAEIIKLPGIGKSTAGAILSFGFNLYSCILDGNIKRVLIRYYSININNKYIEKLLWKTIESITPIYHTNKFNQALIDIGALICLKSNPKCNICPLKSTCKSYLNNKLFQINCKKNKKHIIPKTKYWFLILQYKNYIFLEKRQNLGIWKKLFCFPQFIRQNDILSWIQKNNTKIKKINILNEFKHKLSHLTLYINPIWIIINKISIFSNNNKTIWYNLNNPQCIGLPTPVTKIITKIKKFNTHHE

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
Length
350 amino acids
Function
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Similarity
Belongs to the Nth/MutY family.
Mass
41.589 kDa
Sequence
MTKYIFSQLVLNWYHKNGRKDLPWQINKTLYTVWISEIMLQQTTVKSAIPYFKKFILNFPNIKSLNDSKLDDVLYLWSGLGYYNRAKNIYKSAQIIKKKYKGIFPDQFSNIIQLPGIGRSTAGAILSLSLNFFYPILDGNVKRILVRYYGISGLLKDKKIEKKLWNIIESITPIHNTGKFNQGMMDIGASICISIKPKCTICPLKKECIAQIEKKWEKYPLKNIKKTLPQKISWFIIIKHENNFWLKKNTEQEIWKELFCFPKFKNKEEALIWLKEKKININTCENMISFFHKFSHFILHINPILIRLPYISEFFKENHKKIWYNLKNPQHIGLPRPVQKILENFKKNIF

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Escherichia coli (strain K12)
Length
350 amino acids
Function
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Similarity
Belongs to the Nth/MutY family.
Mass
39.149 kDa
Sequence
MQASQFSAQVLDWYDKYGRKTLPWQIDKTPYKVWLSEVMLQQTQVATVIPYFERFMARFPTVTDLANAPLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGKFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARCYAVSGWPGKKEVENKLWSLSEQVTPAVGVERFNQAMMDLGAMICTRSKPKCSLCPLQNGCIAAANNSWALYPGKKPKQTLPERTGYFLLLQHEDEVLLAQRPPSGLWGGLYCFPQFADEESLRQWLAQRQIAADNLTQLTAFRHTFSHFHLDIVPMWLPVSSFTGCMDEGNALWYNLAQPPSVGLAAPVERLLQQLRTGAPV

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
350 amino acids
Function
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Similarity
Belongs to the Nth/MutY family.
Mass
39.409 kDa
Sequence
MQASQFSAQVLDWYDKYGRKTLPWQINKTPYKVWLSEVMLQQTQVTTVIPYFERFMARFPTVTDLANAPLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGEFPQTFAEIAALPGVGRSTAGAILSLALGKHYPILDGNVKRVLARCYAVSGWPGKKEVENTLWTLSEQVTPARGVERFNQAMMDLGAMVCTRSKPKCTLCPLQNGCIAAAHESWSRYPGKKPKQTLPERTGYFLLLQHNQEIFLAQRPPSGLWGGLYCFPQFAREDELREWLAQRHVNADNLTQLNAFRHTFSHFHLDIVPMWLPVSSLDACMDEGSALWYNLAQPPSVGLAAPVERLLQQLRTGAPV

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Length
347 amino acids
Function
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Similarity
Belongs to the Nth/MutY family.
Mass
41.301 kDa
Sequence
MTIYVFSQLILNWYHINGRKNLPWKKDKTLYKVWISEIMLQQTTVKTAIPYFKNFISRFPNIQSLNQSKLDDILCLWSGLGYYKRAENIYKTVKIIKEEFQEKFPTGFSDLIKLPGIGRSTAGAILSLSLDYFFPILEGNVKRILMRYYGIIGYVTEKKIEQKLWYLIELITPIHNTGSFNQGIMDIGALICTPKNPKCNLCPLIQKCIAYKEKNWIKYPLKKKKKIILEKKSWFVVIKYQNQFWIEKNTEKKIWKNLFCFPNFDTKIKTIEWLKKNKINIDKKHKKIQSFYHKFSHFTLHIIPILVNLSFFKNFQNSKKTGIWYDLKNTHDIGLPKPVQKILEIFK

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
304 amino acids
Function
Adenine glycosylase active on G:A and C:A mispairs, as well as processing 7,8-dihydro-8-oxoguanine:A (8-oxoG) mismatches.
Similarity
Belongs to the Nth/MutY family.
Mass
33.684 kDa
Sequence
MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFMLQQTPAARVLAIWPDWVRRWPTPSATATASTADVLRAWGKLGYPRRAKRLHECATVIARDHNDVVPDDIEILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAVHGRADAGAPSVPRDHADVLALLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTGTDRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALPGEGF

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
304 amino acids
Function
Adenine glycosylase active on G:A and C:A mispairs, as well as processing 7,8-dihydro-8-oxoguanine:A (8-oxoG) mismatches. Minor activity against 8-oxoG:G and 8-oxo:T mismatches is also seen. Bind dsDNA oligonucleotides containing the above mismatches.
Similarity
Belongs to the Nth/MutY family.
Mass
33.684 kDa
Sequence
MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFMLQQTPAARVLAIWPDWVRRWPTPSATATASTADVLRAWGKLGYPRRAKRLHECATVIARDHNDVVPDDIEILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAVHGRADAGAPSVPRDHADVLALLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTGTDRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALPGEGF

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
293 amino acids
Function
Adenine glycosylase active on G:A and C:A mispairs, as well as processing 7,8-dihydro-8-oxoguanine:A (8-oxoG) mismatches.
Similarity
Belongs to the Nth/MutY family.
Mass
31.88 kDa
Sequence
MSISPVELLSWYDHARRDLPWRRPGVSAWQILVSEFMLQQTPVSRVEPIWSAWIERWPTASATAAAGPAEVLRAWGKLGYPRRAKRLHECAVVIASEYDDVVPRDVDTLLTLPGIGAYTARAVACFAYQASVPVVDTNVRRVVTRAVHGAADAPASTRDLDMVAALLPPDTTAPTFSAALMELGATVCTARSPRCGICPLSHCRWRSAGFPAGTVARRVQRYAGTDRQVRGKLLDVLRDSTTPVTRAQLDVVWLSDPAQRDRALDSLLVDGLVEQTADGRFALAGEGETGRPA

Gene
mutY
Protein
Adenine DNA glycosylase
Organism
Aeromonas hydrophila
Length
99 amino acids
Function
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Similarity
Belongs to the Nth/MutY family.
Mass
11.692 kDa
Fragment
single
Sequence
MSNSDNTTFATRILDWYQIHGRKTLPWQQDKTPYRVWVSEIMLQQTQVATVIPYYQRFMARFPDVQALAQAPIDEVLHHWTGLGYYARARNLHKAAQQI