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mupP

Gene
mupP
Protein
N-acetylmuramic acid 6-phosphate phosphatase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
226 amino acids
Function
Specifically catalyzes the dephosphorylation of N-acetylmuramate 6-phosphate (MurNAc-6P) to MurNac (By similarity). Is involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc (PubMed:28351916). Plays a role in intrinsic resistance to fosfomycin, which targets the de novo synthesis of UDP-MurNAc (PubMed:28351916).
Similarity
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. Phosphatase MupP subfamily.
Mass
24.977 kDa
Sequence
MKRMRLKAVLFDMDGTLLDTAPDFIAITQAMRAAHGLPPVDEQRVRDVVSGGARAMVAAAFGLSLDSPEVEPLRQEFLDRYQEHCAVLSRPYDGIPELLAAIEKAGLIWGVVTNKPVRFAEPIMQRLGYAERSRVLVCPDHVTRSKPDPEPLLLACSQLGIDPSRVLFIGDDLRDIESGRDAGTKTAAVRYGYIHPEDNPAHWGADVIVDHPRELIDVLDRALCDC

Gene
mupP
Protein
N-acetylmuramic acid 6-phosphate phosphatase
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Length
223 amino acids
Function
Specifically catalyzes the dephosphorylation of N-acetylmuramate 6-phosphate (MurNAc-6P) to MurNac. Is involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc. Plays a role in intrinsic resistance to fosfomycin, which targets the de novo synthesis of UDP-MurNAc. Shows a very low activity on GlcNAc-6P, and neither alpha-1-phosphorylated MurNAc, GlcNAc, or glucose nor glucosamine-6P or glucose-6P can be used as a substrate.
Similarity
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. Phosphatase MupP subfamily.
Mass
24.373 kDa
Sequence
MRLRAVLFDMDGTLLDTAPDFIAICQAMLAERGLPAVDDNLIRGVISGGARAMVATAFAMDPEADGFEALRLEFLERYQRDCAVHSKLFEGMAELLADIEKGNLLWGVVTNKPVRFAEPIMQQLGLAERSALLICPDHVKNSKPDPEPLILACKTLNLDPASVLFVGDDLRDIESGRDAGTRTAAVRYGYIHPEDNPNNWGADVVVDHPLELRKVIDSALCGC