mtlR

Gene

mtlR

Protein

Transcriptional regulator MtlR

Organism

Bacillus subtilis (strain 168)

Length

694 amino acids

Function

Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol.

Similarity

Belongs to the transcriptional antiterminator BglG family.

Mass

78.853 kDa

Sequence

MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSIKPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLESQEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKIVGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFSLSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGVTIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYSLYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDEIAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIELKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSSKEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKDGLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGMDGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNRIFFTWMKEKNIL

Protein

Transcriptional regulator MtlR: mtlR

Gene

mtlR

Protein

Putative transcriptional regulator MtlR

Organism

Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

Length

650 amino acids

Function

Not necessary for mannitol utilization. May be involved in regulation of the mannitol phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).

Mass

75.338 kDa

Sequence

MLLTKREKHLLAAFQNYGKLSLKQMIDLLKVSQRTVYRTISDLTDSLNTINISIIKENQNYFLVGELANLASIISLDTYEQYERLNLITYKLLMSFSSITNEQLQEEFNVSNVTIIQDIAEIEKRLADFDLRLDRKKGYRLVGNKNTLRRLLAILLTNNLSISDFGAGAYGHFEVLDKAKLELAKQIFQSSQEDLPDLDAKMSEFFIILLALSGWRDNEAVGHSISKAALDFSQKVYTEFSQKTNQFYSIQEILYYASILDELVIKRQETPLFHEKFDSAFFYNISNLIDKVSLYTKINFAKDKTLFHFLFNHIRLNLAVPQIFEDKSNNTIAHEVVQGNEYLHRVVSLLVQDIFPKYLQKEPEYELITLHFASSLRRSPDIYPIKILLLTDERPLARELLITRIKTIAPFVDKVVVKELAQYETKDKDYYNCVLATKPLVDKAVKMVSTYPDAKEMLQLQDYLQNVQAHQKIIIRDEQTNKQGYNLQNYFLATQQLLQEFSYQEIDNPADFETSVPKIMETIAAVSDKTYLSSKLLKCFAVSPLAIPETHLALLHTQSSKVITSCFKIYDLKRPVTALSMNYEKETVTRILVMLTRLDETKEMRDLMTAISQSIIENHLYTEIYKTGNKDIIYQLLNQIFTEKIKKLET

Protein

Putative transcriptional regulator MtlR: mtlR

Gene

mtlR

Protein

Mannitol operon repressor

Organism

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

Length

195 amino acids

Function

Involved in the repression of the expression of the mannitol mtlADR operon. Does not bind the operator/promoter regulatory region of this operon. Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex.

Similarity

Belongs to the MtlR/FumE family.

Mass

21.99 kDa

Sequence

MVDQAQDTLRPNNRLSDMQATMEQTQAFENRVLERLNAGKTVRSFLITAVELLTEAVNLLVLQVFRKDDYAVKYAVEPLLDGDGPLGDLSVRLKLIYGLGVINRQEYEDAELLMALREELNHDGNEYAFTDDEILGPFGELHCVAALPPPPQFEPADSSLYAMQIQRYQQAVRSTMVLSLTELISKISLKKAFQK

Protein

Mannitol operon repressor: mtlR

Gene

mtlR

Protein

Mannitol operon repressor

Organism

Escherichia coli (strain K12)

Length

195 amino acids

Function

Involved in the repression of the expression of the mannitol mtlADR operon (PubMed:8300537). Does not bind the operator/promoter regulatory region of this operon (PubMed:19840941). Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex.

Similarity

Belongs to the MtlR/FumE family.

Mass

21.99 kDa

Sequence

MVDQAQDTLRPNNRLSDMQATMEQTQAFENRVLERLNAGKTVRSFLITAVELLTEAVNLLVLQVFRKDDYAVKYAVEPLLDGDGPLGDLSVRLKLIYGLGVINRQEYEDAELLMALREELNHDGNEYAFTDDEILGPFGELHCVAALPPPPQFEPADSSLYAMQIQRYQQAVRSTMVLSLTELISKISLKKAFQK

Protein

Mannitol operon repressor: mtlR