Protein
Modification methylase MthZI
Organism
Methanothermobacter thermautotrophicus
Function
This methylase recognizes the double-stranded sequence CTAG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the MthZI endonuclease.
Similarity
Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.
Sequence
MKTTHRIYFKNSADMNELKDKSINLVVTSPPYPMVEIWDRLFSELNPKIEETLIDEEDGLRSYNLMHEELEKVWHEVDRVTAPGGVVIINIGDATRKIGKKFQLYPNHVRTIDFFFDRGYQVLPFIIWRKQSNKPTKFMGSGMLPPNAYVTHEHEYILIFRKEGPRQFKTEEERKLRRESAYFWEERNQWFSDVWTDLTGVSQRLNHKNLRKRAAAYPFELAYRLINMYSIMGDWVLDPFLGTGTTMIAAACAGRNSIGYELDHNFKDLIESRINETLKLSNEIVMRRINDHIEFIREKNGKYYSENYKFKVTTRQEQDIRLYYPRTYKKIKNNEFEFFYQEVNPKKERQSKLNI