Protein
Membrane-bound lytic murein transglycosylase F 1
Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Function
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
Similarity
In the C-terminal section; belongs to the transglycosylase Slt family.
Sequence
MRIMAVRLVAGAITLALMAYAWLAWERARDPEPITILERVLERGELRVITRISATTYYQTDKGRAGLEFELAQAFAHRLGVQLRMLVAPDLEAIFAALDDGEADLAAAGLTYTESRGQRYWFTPPYKDITQQLVYRVGTPRPDDLSEIGPGELAVIANSSHADRLRELRNRSHPDLTWAEDEHADSEAMLYRVWNEELRYTVADSHELSINRAYYPELRKAFEISGVEGLAWAFPRTEDLSLYNEAARYFTDLRLEGTLSTLLEEHFGHLGRFDYVGFRAFNRHVADRLPRYRHWFEEAAEEYGVDWRLLAAIGYQESHWDPQAVSPTGVRGIMMLTLDTASMLGVDNRLDPKQSIFGGARYFSRLLERLPEDIEEPHRAWMALAAYNVGYGHLQDARRLARQRGYDPNDWRVIRDHLPLLSQRQWYVQTRHGYARGWEPVHYVRNIRLYYQLLQRITEPGRRQVPAGEALGEPPLPTPPAPPGAPLPADPPAD