MKRN1

E3 ubiquitin-protein ligase makorin-1

482 amino acids

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.

53.349 kDa

MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL

Mkrn1

E3 ubiquitin-protein ligase makorin-1

481 amino acids

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase (By similarity). Has negative and positive effects on RNA polymerase II-dependent transcription.

53.008 kDa

MAEAAAPGTTATTSGAGAAAAAVAAASLTSIPTVAAPSPGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGDRCRYEHSKPLKQEEVTATDLSAKPSLAASSSLSSGVGSLAEMNSGEAESRNPSFPTVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEVPPQGSVTKEESEKEPTTVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPVDAAQRSQHIKSCIEAHEKDMELSFAVQRTKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRSHFWELIEERENNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL

MKRN1

E3 ubiquitin-protein ligase makorin-1

478 amino acids

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.

52.905 kDa

MAEAAAPGTTATTSGAAAAAAVAAASPTLTPTVASQSPAAGGGGGGSGGGWTKQVTCRYFMHGVCKKGNNCRYSHDLSTSQSAMVCRYYQRGCCAYGDRCRYEHTKPLKREEVTAANLAAKSDLPASSSLPALVEPLAEVSTGEAESVNSNFAAAGAGGEDWVNAIEFVPGQPYCGRAAPSCTEAPLQGMVIEEELEKQQTNVEMKKQLCPYAAVGECRYGENCVYLHGDACDMCGLQVLHPVDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKPCRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSNRYRAQRRNRFWELIEERESSNPFDNDEDEVVTFELGEMLLMLLAAGGDDDLTDPEDEWDLFHDELEDYYDLDL

mkrn1

Probable E3 ubiquitin-protein ligase makorin-1

439 amino acids

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

49.7 kDa

MAEAAAASTAAPAVIGGWTKHVTCRYFMHGLCKEGENCRYSHDLSSCKQTMICKFFQKGCCAFGDRCRYEHTKPSKQDEVPSSKPSMPLTAAPLAGTPEPVSDGPGGTTGAQEKPQGSGAVDWVNAAEFVPGQPYCGRADPVLCEGPGPLIEEEYEKEQANKEMKKQLCPYAAVGECRYGLNCAYLHGDVCDMCGLQVLHPSDTSQRSQHIRACIEAHEKDMEISFAIQRSKDMMCGVCMEVVFEKTNPSERRFGILSNCCHCYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEDKEEKQQLIQKYKDGMGTKPCRYFDEGRGTCPFGANCFYKHAFPDGRLEEPQPQRRQNGSNGRNRNTRRTHLWDLLDERENSDSFDNEDEEMVRFELSEMLLMLLAAGTDDDVTDSEDEWDLFHEELDDYYELYL

mkrn1

Probable E3 ubiquitin-protein ligase makorin-1

435 amino acids

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

48.929 kDa

MAEAAAASTAASGVIGGWTKHVTCRYFMHGLCKEGDNCRYSHDLTNSKPAAMICKFFQKGNCVFGDRCRFEHCKPAKNEELPAPQMLPLPSASLAGPSDPEPSGPTPVPGAQDWVNAAEFVPGQPYCGRAEQAKVESSVPLIEEFDSYPAPDNKQLRKQLCPYAAVGECRYGINCAYLHGDVCYMCGLQVLHPTDNNQRSEHTKACIEAHEKDMEISFAIQRSKDMMCGVCMEVVFEKANPSERRFGILSNCSHCYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEDKDDKQKLIQKYKDGMGSKPCRYFDEGRGTCPFGSNCFYKHAFPDGRLEEAQPQRRQTGSNSRNRNSRRTPLWDIYDERESTDSFDNEDEEMVTFELSEMLLMLLAAGTDDEEVIIRPPSCATSSGRLDPTVTRYRKAC

mkrn1

Probable E3 ubiquitin-protein ligase makorin-1

429 amino acids

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

48.903 kDa

MAEAAVASTVTLPVTGGWTKHVTCRYFMHGLCKEGDNCRYSHDLTSSKPAAMMCKFFQKGNCVFGERCRFEHCKPTKSEEVSNPQMLLLSSTPPPIDPECSESGPRLKTQDWANAAEFVPGQPYCGRAESVDVEISIPLIEELNGDATTDKEELRKQLCPYAAVGECRYGVNCAYLHGDVCDMCGLQVLHPTDSSQRSEHTKACIEAHEKDMEISFAIQRSKDMMCGVCMEVVFEKANPSERRFGILSNCSHCYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEDKEDKQKLIQKYKDGMGRKPCRYFDEGRGICPFGANCFYKHAFPDGRLEEAQPQRRQTGSSSRNRNSRRTQLWDIIDERESTGSLDNDDEEMVTFELSEMLLMLLAAGNDEEVTDSEDEWDLFHEELDDFYEIYL

mkrn1

Probable E3 ubiquitin-protein ligase makorin-1

408 amino acids

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

45.635 kDa

MAEAAAAPALLTSAASAGKAPLPAFPENPPVGVWTRHVTCRYFIHGVCKEGINCRYSHDLATSRSAMICRYFQRGCCAYGDRCRYEHNKPLQEDPTGDTCTAPSESLPEPSGNINSKAAELAASELASGGPRAQDWVNAVEFVPGQLYSGRAPEAYTQGTVKPDEGREEPADPELKKQLCPYAAMGECRYGENCVYLHGDPCDMCGLQVLHPVDTCQRSQHIKSCIEAHEKDMELSFAVQRSKDIVCGICMEVVYEKTNPSERRFGILSNCSHSYCLKCIRKWRSAKQFESKIIKSCPECRITSNFIIPSEYWVEEKEEKHKLIHKYKEAMSSKSCRYFDEGRGTCPFGGNCFYRHAYPDGRIEEPQPRQKSGMSSRYRIPSPSAGIDFGSLTSERAETRLRTRKTKL

mkrn1

Probable E3 ubiquitin-protein ligase makorin-1

372 amino acids

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

41.931 kDa

MAEAAVASTVTLPVSGGWTKHVTCRYFMHGLCKEGDNCRYSHDLTNSKPAAMICKFFQKGNCVFGERCRFDHCKPTKNEEFSSPQMLPPSSPSPSTDPESSQPAPRPKTQDWANAAEFVPGQPYCGRAESVKVEISIPLIEELDCDAAVDKEALRKQLCPYAAVGECRYGINCAYLHGDVCDMCGLQVLHPTDNSQRSQHTKACIEAHEKDMEISFAIQRSKDMMCGVCMEVVFEKANPSERRFGILSNCNHCYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEDKEDKQKLIQKYKDGMGRKPCRYFDEGRGICPFGANCFYKHAFPDGRLEEAQPQRRQTGSSSRNRLSEMLLMLLAAGD