E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.

478 amino acids

MAEAAAPGTTATTSGAAAAAAVAAASPTLTPTVASQSPAAGGGGGGSGGGWTKQVTCRYFMHGVCKKGNNCRYSHDLSTSQSAMVCRYYQRGCCAYGDRCRYEHTKPLKREEVTAANLAAKSDLPASSSLPALVEPLAEVSTGEAESVNSNFAAAGAGGEDWVNAIEFVPGQPYCGRAAPSCTEAPLQGMVIEEELEKQQTNVEMKKQLCPYAAVGECRYGENCVYLHGDACDMCGLQVLHPVDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKPCRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSNRYRAQRRNRFWELIEERESSNPFDNDEDEVVTFELGEMLLMLLAAGGDDDLTDPEDEWDLFHDELEDYYDLDL

52.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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