mbtB

Phenyloxazoline synthase MbtB

1414 amino acids

Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores (By similarity).

Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.

151.606 kDa

MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYRILLADLAALYDGREPPALGYTYQEYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVTEFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVETFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGHCMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR

mbtB

Phenyloxazoline synthase MbtB

1414 amino acids

Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores. Essential for growth in macrophages.

Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.

151.634 kDa

MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPVAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYRILLADLAALYDGREPPALGYTYREYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAAARAQAVQEALRTAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVTEFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVETFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGHCMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR

mbtB

Phenyloxazoline synthase MbtB

1414 amino acids

Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores. Essential for growth in macrophages.

Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.

151.634 kDa

MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYRILLADLAALYDGREPPALGYTYREYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVTEFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVETFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGHCMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR

mbtB

Phenyloxazoline synthase MbtB

1167 amino acids

Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores (By similarity).

Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.

125.554 kDa

MEAVVTSSQTVRAEVAELLGIEESALDPDADLIASGLDSIRMMSLSGRWRKQGIDVRFAAMAANPTVAAWTRLVGERTAESPGAATQSGDTAASAGDPDAPFPLAPIQHALWVGRNELTELGGVAAHLYVEFDGAGVDPERLRTAAAALAARHPMLRVDILGDGMQRISDRDLPVKVTDLRHLDVADAEQQLEVIRHAKSHQLLEGEVLELALTLLPDGRTRLHVDLDMQAADAVSYRNFMADLAALYRGAQLPELQYTYRQYRSAFTATPAPTVDEDRRWWTERIPDLPEPPALPLVPRAEQRDPRRGTRRWHFLDTDIRDRLFAAARARGITPAMAFAASYAGTLARWSTSRHFLLNLPMFGREPFHPDVDKLVGDFTSSLMLDVDFTEAHTPAQRARVMQEALHTSAEHATYSGLSVLRDLSRHHGSPSLAPFVFTSALGLGDLFAGDVTDQFGTPVWHISQGPQVLLDAQVTPFDGGLLVNWDVREDAFRPGVIDAMFAYQLAELERLAADDAAWDAADPPAVPPAQRAVRDAVNDTGARRSDDALHDGFFRTAAHTPDATAVIGSTGTLTYAELRERVLAVTGALQVAGIKPGDTVAVMGPKCADQVTALLAIHAAGAVYVPIGADQPADRADSILQTAGVRMALACGDEPPTFLPALTIAEAVRVGSRVHGVTPATVEPDRVAYVLFTSGSTGAPKGVEVTHAAAMNTLEFINDHFGIGPSDRSLALSTLEGDLSVLDVFGMLRAGGSLVVVDEAQRRDPDSWARLIAEHSVTVLHWMPGWLEMLLEVGGALPSVRVVPTGGDWVRTEMVRELRRAAPGVRFAGLGGATETAIHNTICEPGELPREWSAVPFGRPLPNNACRVVAADGADCPDWVPGELWVGGRGIARGYRGRPDLTAERFVVHDGRTWYRTGDLVRYLPDGQIDFVGRADHRVKISGYRIELGEVEAALRRIAGVEAAVAAVLTAPGDGRGEQLAAIVRASSPAVTVDELTRRMAELVPPHMVPSHIALVEAVPFTVGGKIDRRAVTAELTRSMAERANAQAPTYRVPSTALERALADIVSTVLDRDSVGADDDFFELGGDSVLATQAVARIREWLDSPGVMVTDIFAARRVGALARRLVDHESGSDRLEGVAELYLEVADMNSADVASALHSTSAQASR

mbtB

Phenyloxazoline synthase MbtB

1165 amino acids

Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores (By similarity).

Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.

125.043 kDa

MVHAPARSEDIREEVAELLGVDVDAVQPGSNLIGQGLDSIRIMTLAGRWRRRGIAVDFATLAETPTIEAWAQLVTAGRQDTDSAAPPADSSGDPSGETEPFALAPMQHAMWVGRQDNQQLGGVAGHLYVEFDAGLLDSGRLRAAATALARRHPMLRVRFLPDGTQCITPAVECGDFPVHVEDLRELGTDEVERRLTALREAKSHQQLDGAVFELTVTLLPGGRSRLHVDLDMQAADAMSYRTLMADLAALYRGCDLPELSYTYRQYRHAVEAQDAQPQPRRDADRDWWARRLPELPDPPALPITAGRGANRSTRRWHWLDPQTRDALFARAQARGITPAMALAAGFANTLARWSSNSRFLLNVPLFGRQPLHPDVDALVGDFTSSLLLDVDLVGAHTAAARAQVVQDAMRTAAAHSAYSGLSVLRDLSRHRGTQVLAPVVFTSALGLGELFSPEVTGQFGTPAWIISQGPQVLLDAQVTEFDGGVLVNWDVREGFFPPGVIDAMFAYHIDELLRLASADDAWDAPGPAALPEAQRAVREAINGRTAPPSGEALHDRFFRQAERQPDAPAVFAGSGDLSYAQLRDQALAVAAALRAAGAGAGDTVAVVGPKSAEQIPAVLGILSVGAAYLPIGADQPRDRAERILQSGRVRLALVCGGRQLSLPVPGLVLADVLGGAPADAEIACARVDPGELAYVLFTSGSTGEPKGVEVTHDAAMNTVEFIGRHFEIGPADRCLALSTLEGDISVMDVFVTLRTGGAIVVVDEAQRRDPDAWARLIDTHRVTVLHFMPGWLEMLVEVGRGRLSSVRVVPTGGDWVRPEVVRRLRAEAPGLRFAGLGGATETPVHNTIFEVTEPIPADWTALPFGVPLPNNVCRVVGDTGGDCPEWVPGELWVSGRGIARGYRGRPDLTAQRFVEHDGRTSYRTGDLVRYRPDGTLEFVGRADHRVKISGYRVELGEIESALRRVPGVRTAVAALIAGAGESDVLAAQVGTDDPALTGEQVRQYLADLVPAHMIPRHVAVVERIGFTAAGKLDRRAVARELHSVVGQSHSPGHRAASTPLEGALALILGDLLGRDDVGVDDDFFALGGDSVLATQAVARIRAWLDAPDVMVADMFANRTVSALAAVLRAAEDDPDRLDHVAELYLEVIGMDAESVLTATRQTTKS