lin-45

Raf homolog serine/threonine-protein kinase

813 amino acids

Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60 (PubMed:8483497, PubMed:11861555, PubMed:14724126). Required for progression of developing oocytes through the pachytene stage (PubMed:19826475). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Positively regulates lifespan upstream of mek-2 and mpk-1 (PubMed:20624915).

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

90.407 kDa

MSRINFKKSSASTTPTSPHCPSPRLISLPRCASSSIDRKDQASPMASPSTPLYPKHSDSLHSLSGHHSAGGAGTSDKEPPKFKYKMIMVHLPFDQHSRVEVRPGETARDAISKLLKKRNITPQLCHVNASSDPKQESIELSLTMEEIASRLPGNELWVHSEYLNTVSSIKHAIVRRTFIPPKSCDVCNNPIWMMGFRCEFCQFKFHQRCSSFAPLYCDLLQSVPKNEDLVKELFGIASQVEGPDRSVAEIVLANLAPTSGQSPAATPDSSHPDLTSIKRTGGVKRHPMAVSPQNETSQLSPSGPYPRDRSSSAPNINAINDEATVQHNQRILDALEAQRLEEESRDKTGSLLSTQARHRPHFQSGHILSGARMNRLHPLVDCTPLGSNSPSSTCSSPPGGLIGQPTLGQSPNVSGSTTSSLVAAHLHTLPLTPPQSAPPQKISPGFFRNRSRSPGERLDAQRPRPPQKPHHEDWEILPNEFIIQYKVGSGSFGTVYRGEFFGTVAIKKLNVVDPTPSQMAAFKNEVAVLKKTRHLNVLLFMGWVREPEIAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERLRDIILPKLTRSQSAPNVLHLDSQYSVMDAVMRSQMLSWSYIPPATAKTPQSAAAAAAANKKAYYNVYGLI

lin-45

Raf homolog serine/threonine-protein kinase

811 amino acids

Protein kinase that participates in the induction of vulva and has a role in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Positively regulates lifespan upstream of mek-2 and mpk-1.

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

89.98 kDa

MSRINLKKSSAATTPTSPHCPSPRLISLPRCASSSIDRKDQGSPMASPSTPLYPKHSDSLHSLSGHDHSGVGTSDKEPPKFKYKMIMVHLPFDQHSRVEVRPGETARDAISKLLKKRNITPQLCQVNTSPDSKTEAIDLSKTMEEIALHLPDNELWVHSEYLNTVSSIKHAIVRRTFIPPKSCDVCNNPIWMMGFRCEFCQFKFHQRCSSFAPLYCDLLQSVPKNEDLVKQLVGIASENDGPDRSVAEIVLAGLAPTYGQSPAATPDSSHPDLTSIKRTGGVKRHPLAVSPQAETAQLSPAGPYPRDRSSSAPNINAINDEATVQHNQRILDALEAKRLEEESKDKTGSLLSTQARRPHCYSGHILSGSRMNRLHPLVDCTPLGSNSPSSTCSSPPGGLMGPTLLGQSSSVSGSTTSSLVAAHLHTLPLTPPQSAPPQKISPGFFRNRSRSPGERIEAQRPRPPQKPQHEDWEILPNEFVIHYKVGSGSFGTVYRGEFFGTVAIKKLNVVDPTPSQMAAFKNEVAVLKKTRHLNVLLFMGWVREPEIAIITQWCEGSSLYRHIHVQEPRVEFEMSAVIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDDNPYTPQSDVYSFGVCMYEILSSHLPYSNINNRDQILFMVGRGYLKPDRSKIRTDTPKSLMKLYDNCIMFDRNERPVFGEVLERLRDIILPKLTRSQSAPNVLHYDSQYSVMDAVMRSQMVSSSYIPPSTAKTPQSAAAAAAANKKAYYNVYGLI