Protein
Lactoyl-CoA dehydratase subunit alpha
Organism
Clostridium propionicum
Function
Involved in the acrylate pathway for the conversion of D-lactic acid to propionic acid. Catalyzes the reversible dehydration of Lactoyl-CoA and 2-hydroxybutyroyl-CoA to acryloyl-CoA and crotonyl-CoA, respectively.
Similarity
Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
Sequence
MSLTQGMKAKQLLAYFQGKADQDAREAKARGELVCWSASVAPPEFCVTMGIAMIYPETHAAGIGARKGAMDMLEVADRKGYNVDCCSYGRVNMGYMECLKEAAITGVKPEVLVNSPAADVPLPDLVITCNNICNTLLKWYENLAAELDIPCIVIDVPFNHTMPIPEYAKAYIADQFRNAISQLEVICGRPFDWKKFKEVKDQTQRSVYHWNRIAEMAKYKPSPLNGFDLFNYMALIVACRSLDYAEITFKAFADELEENLKAGIYAFKGAEKTRFQWEGIAVWPHLGHTFKSMKNLNSIMTGTAYPALWDLHYDANDESMHSMAEAYTRIYINTCLQNKVEVLLGIMEKGQVDGTVYHLNRSCKLMSFLNVETAEIIKEKNGLPYVSIDGDQTDPRVFSPAQFDTRVQALVEMMEANMAAAE